Novel predictors of survival among breast cancer patients with/without HIV in South Africa

南非感染/未感染艾滋病毒的乳腺癌患者生存的新预测因素

• 批准号: 10845712
• 负责人: Herbert Cubasch
• 金额: $ 12.5万
• 依托单位: WITS HEALTH CONSORTIUM (PTY), LTD
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10845712
• 关键词: African; Age Years; Awareness; Breast Cancer Patient; Clinical; Cohort Studies; Data Set; Development; Disease; Doctor of Philosophy; Early Diagnosis; Early treatment; Epidemiologist; Epidemiology; Fellowship; Female; Funding; Goals; Grant; HIV; HIV Seronegativity; HIV Seropositivity; Health Services Research; Hospitals; International; Interview; Investments; Knowledge; Lead; Leadership; Link; Malignant Neoplasms; Manuscripts; Medical Oncologist; Mental Health; Mentors; Outcome; Patient-Focused Outcomes; Postdoctoral Fellow; Program Development; Public Health; Research; Research Personnel; Research Project Grants; Research Proposals; South Africa; South African; Specialist; Stage at Diagnosis; Students; Supervision; Treatment Factor; Universities; Wit; Woman; anticancer research; career; career development; comorbidity; disparity reduction; experience; graduate student; interest; malignant breast neoplasm; mortality; novel; oncology service; parent grant; professor; programs; response; skills; sociodemographics; socioeconomics; survival prediction; young woman

Project Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-CA-23-038. In this research and mentoring application linked to our existing R01-funded South African Breast Cancer and HIV Outcomes (SABCHO) cohort study, Dr Witness Mapanga proposes to conduct a study to characterize and compare the sociodemographic, clinical, determinants of stage at diagnosis and overall survival among young women (less than 40 years old) with breast cancer (BC), with and without comorbid HIV. Dr Mapanga will also assess through in-depth interviews among 30 young women with BC with and without coexisting HIV, their knowledge and awareness of BC, experiences of their disease and its treatments, socioeconomical and mental health impacts and support needs at the Chris Hani Baragwanath Academic Hospital (CHBAH), in Soweto, Johannesburg, South Africa (SA). Dr Mapanga is a young epidemiologist and public health researcher with experience in cancer and other noncommunicable diseases (NCD), based at the Strengthening Oncology Services Research Unit (SOSRU) of the University of Witwatersrand (Wits), Johannesburg, South Africa. His leadership, mentoring and grants acumen development, supported by South African and international mentoring group, would be an excellent investment for his independent career development in Southern African cancer research for decades to come. Having completed a PhD in Epidemiology and postdoctoral Fellowships, he is now ready to establish, lead and sustain his own research program and supervise embedded postgraduate students. Dr Mapanga together with his parent grant mentors, Dr Maureen Joffe (SA contact PI and primary mentor), Professor Dan O’Neil (Medical Oncologist co-I from Yale U, USA), and Professor Shane Norris (SA mentoring co-I), has developed the research proposal which aims to (i) characterize 480 young women (<40 years of age) with breast cancer from the SABCHO dataset, comparing the 59% HIV-positive and 41% HIV-negative cases on sociodemographic, clinical, and treatment factors and overall survival; (ii) compare determinants of the stage at diagnosis among them and iii) from in-depth interviews with 30 young women (<40 years) with BC (50% HIV- positive), assess their experiences and impact of BC and its treatments and support needs. To hone Witness’s supervision skills, he will include in the research, 3 young female cancer specialists at CHBAH who treat our SABCHO patients to develop manuscripts from research findings and upskill their research acumen. Findings will support strategies to reduce mortality from breast cancer among young women and reduce disparities to their early diagnosis and treatment in SA. Dr Mapanga will gain invaluable experience in independently leading the research project, supervising his mentees, and will receive skilled leadership, supervision, grantsmanship mentoring and research program development guidance to equip him to establish and lead his own independent research program within SOSRU.

项目摘要 本申请是为了响应特殊利益通知（NOSI）而提交的，该通知被确定为 NOT-CA-23-038 在本研究和指导申请中，与我们现有的 R01 资助的南非相关。 乳腺癌和艾滋病毒结果 (SABCHO) 队列研究，Witness Mapanga 博士提议进行一项研究 描述和比较诊断时和总体阶段的社会人口统计学、临床、决定因素 患有乳腺癌 (BC) 的年轻女性（小于 40 岁），无论是否患有艾滋病毒合并症，其生存率。 Mapanga 博士还将通过对 30 名患有 BC 或未患有 BC 的年轻女性进行深入访谈进行评估 共存的艾滋病毒、他们对 BC 的知识和认识、他们的疾病及其治疗的经验、 克里斯·哈尼·巴拉格瓦纳特学院的社会经济和心理健康影响以及支持需求 南非约翰内斯堡索韦托医院 (CHBAH) 马潘加博士是一位年轻的流行病学家和 具有癌症和其他非传染性疾病 (NCD) 经验的公共卫生研究人员，总部设在 加强威特沃特斯兰德大学 (Wits) 的肿瘤学服务研究单位 (SOSRU)， 南非约翰内斯堡，他的领导、指导和资助，得到了南非的支持。 非洲和国际导师团队将是他独立职业生涯的绝佳投资 南部非洲癌症研究未来几十年的发展已完成博士学位。 流行病学和博士后奖学金，他现在准备建立、领导和维持自己的研究 计划和监督嵌入式研究生。 Mapanga 博士和他的家长资助导师 Maureen Joffe 博士（SA 联络 PI 和主要导师）， Dan O’Neil 教授（美国耶鲁大学医学肿瘤学家 co-I）和 Shane Norris 教授（SA 导师） co-I）制定了一项研究提案，旨在 (i) 描述 480 名年轻女性（<40 岁）的特征 与来自 SABCHO 数据集的乳腺癌相比，比较了 59% HIV 阳性和 41% HIV 阴性病例 社会人口统计学、临床和治疗因素以及总体生存率；(ii) 比较各阶段的决定因素 iii) 来自对 30 名患有 BC 的年轻女性（<40 岁）的深入访谈（50% HIV- 积极），评估他们的经验和 BC 的影响及其治疗和支持需求。 监督技能，他将在研究中纳入 CHBAH 的 3 名年轻女性癌症专家，她们治疗我们的 SABCHO 患者根据研究结果撰写手稿并提高他们的研究敏锐度。 将支持降低年轻女性乳腺癌死亡率并缩小男女差异的战略 他们在南澳的早期诊断和治疗将获得独立领导的宝贵经验。 研究项目，监督他的学员，并将获得熟练的领导、监督、资助 指导和研究项目开发指导，帮助他建立和领导自己的独立性 SOSRU 内的研究计划。

项目成果

Quality of Histopathological Reporting in Breast Cancer: Results From Four South African Breast Units.

乳腺癌组织病理学报告的质量：来自四个南非乳腺科的结果。

• 发表时间: 2021
• 影响因子: 4.5
• 作者: Toma, Armand;O'Neil, Daniel;Joffe, Maureen;Ayeni, Oluwatosin;Nel, Carolina;van den Berg, Eunice;Nayler, Simon;Cubasch, Herbert;Phakathi, Boitumelo;Buccimazza, Ines;Čačala, Sharon;Ruff, Paul;Norris, Shane;Nietz, Sarah
• 通讯作者: Nietz, Sarah

Impact of HIV infection on survival among women with stage I-III breast cancer: Results from the South African breast cancer and HIV outcomes study.

HIV 感染对 I-III 期乳腺癌女性生存的影响：南非乳腺癌和 HIV 结果研究的结果。

• 发表时间: 2022-07-15
• 影响因子: 6.4
• 作者: Ayeni, Oluwatosin A;O'Neil, Daniel S;Pumpalova, Yoanna S;Chen, Wenlong Carl;Nietz, Sarah;Phakathi, Boitumelo;Buccimazza, Ines;Čačala, Sharon;Stopforth, Laura W;Farrow, Hayley A;Mapanga, Witness;Joffe, Maureen;Chirwa, Tobias;McCormack, Valerie
• 通讯作者: McCormack, Valerie

Degree of food processing and breast cancer risk in black urban women from Soweto, South African: the South African Breast Cancer study.

南非索韦托城市黑人女性的食品加工程度和乳腺癌风险：南非乳腺癌研究。

• 发表时间: 2022-12-14
• 作者: Jacobs, Inarie;Taljaard;Wicks, Mariaan;Cubasch, Herbert;Joffe, Maureen;Laubscher, Ria;Romieu, Isabelle;Levy, Renata B;Rauber, Fernanda;Biessy, Carine;Rinaldi, Sabina;Huybrechts, Inge
• 通讯作者: Huybrechts, Inge

The impact of HIV on non-adherence for tamoxifen among women with breast cancer in South Africa.

艾滋病毒对南非乳腺癌女性不坚持服用他莫昔芬的影响。

• 发表时间: 2023-02
• 影响因子: 3.8
• 作者: Ayeni, Oluwatosin A;Chiwambutsa, Shingirai;Chen, Wenlong Carl;Kapungu, Nyasha;Kanji, Comfort;Thelingwani, Roslyn;Murugan, Nivashni;Mathiba, Rofhiwa;Phakathi, Boitumelo;Nietz, Sarah;Ramiah, Duvern;O'Neil, Daniel S;Jacobson, Judith S;Ruff, Paul
• 通讯作者: Ruff, Paul

The Impact of HIV Infection on Neoadjuvant and Adjuvant Chemotherapy Relative Dose Intensity in South African Patients with Breast Cancer.

HIV 感染对南非乳腺癌患者新辅助和辅助化疗相对剂量强度的影响。

• 发表时间: 2023-10-03
• 作者: O'Neil, Daniel S;Ayeni, Oluwatosin A;Farrow, Hayley A;Chen, Wenlong Carl;Demetriou, Georgia;Buccimazza, Ines;Čačala, Sharon;Stopforth, Laura W;Joffe, Maureen;Antoni, Michael H;Lopes, Gilberto;Pumpalova, Yoanna S;Mapanga, Witness;Jacobson, Jud
• 通讯作者: Jacobson, Jud