Pathology and Biorepository

病理学和生物样本库

• 批准号: 8340242
• 负责人: KEVIN J. CULLEN
• 金额: $ 6.67万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-24 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340242
• 关键词: Anatomy; Archives; Baltimore; Biology; Cancer Center; Cancer Center Support Grant; Clinical Investigator; Confidentiality of Patient Information; Consultations; Databases; Diagnosis; Diagnostic; Effectiveness; Ensure; Evaluation; Formalin; Freezing; Genomics; Histology; Image Analysis; Institutional Review Boards; Instruction; Knowledge; Laboratories; Lesion; Libraries; Maryland; Mission; Normal tissue morphology; Operative Surgical Procedures; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Preparation; Proteomics; Research; Research Personnel; Resources; Retrieval; Sampling; Services; Specimen; Surgical Pathology; Techniques; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translating; Tumor Pathology; Universities; base; biobank; clinical application; digital imaging; experience; human tissue; protocol development; success; tissue processing; tumor

PROJECT SUMMARY (See instructions): The Pathology and Biorepository Shared Service (PBSS) at the University of Maryland Marlene and Stewart Greenebaum Cancer Center (UMGCC) has two main missions: (1) provide access to a consistently excellent quality of banked patient samples (tissue and other preparations) while maintaining patient confidentiality and (2) provide pathology, histology, and histotechnology consultation services to assist clinical investigators in the procurement, analyses, and clinicopathologic correlation of human tissue specimens. Through access to tissue specimens, investigators can perform analyses (e.g., genomic or proteomic studies) to understand the biology of normal and diseased tissues and then translate that knowledge for diagnostic and clinical applications. PBSS is the only tissue bank shared service for specimens removed at surgery at the University of Maryland-Baltimore (UMB) campus. PBSS has an integrated relationship with the Division of Anatomic Pathology of the Department of Pathology, which is essential for obtaining well-characterized tissue samples and pathology and histology expertise. In addition to the ongoing banking of all sold tumors,PBSS also provides investigator-specific tissue procurement and processing; access to more than 7,000 frozen tumor samples, of which 5,900 are paired with normal tissue from the same patient; and access to the formalin-fixed paraffin-embedded (FFPE) specimen archive of the Anatomic Pathology Laboratory, which consists of more than 1,260,000 FFPE tissue blocks with various pathologic diagnoses. PBSS performs searches of the frozen sample library and the surgical pathology archive for sets of specific samples, with subsequent retrieval of specimens and confirmation ofthe presence of relevant lesion/tumor by Drs. Olgaloffe or William Twaddell. The provision of clinicopathologic parameters is available upon request, depending on the specific research question. PBSS staff possess extensive experience with a wide range of techniques and specimen types. PBSS offers consultation with pathologists for protocol development and tissue evaluation; Institutional Review Board issues; technical support; and expertise for routine histological and immunohistochemical analyses of research specimens, digital image analysis, and tissue microarray construction. The success and effectiveness of PBSS is based on its ability to integrate its pathology and biorepository resources and expertise into research being conducted at UMGCC.

项目摘要（请参阅说明）： 马里兰大学马琳大学和斯图尔特·格林鲍姆癌症中心（UMGCC）的病理和生物座位共享服务（PBSS）有两个主要任务：（1）提供始终如一的良好质量的存放患者样本（组织和其他准备工作）（组织和其他准备工作），同时保持患者的机密性，并提供病理学，组织学和组织学咨询服务，组织学，组织学和组织学咨询服务。 在采购中，人体组织标本的分析和临床病理相关性。通过进入组织标本，研究人员可以进行分析（例如，基因组或蛋白质组学研究），以了解正常组织和患病组织的生物学，然后将这些知识转化为诊断和临床应用。 PBSS是唯一在手术中去除手术标本的纸币共享服务 马里兰州 - 巴尔提莫尔大学（UMB）校园。 PBSS与病理学系的解剖病理学分裂有综合关系，这对于获得特征良好的组织样本以及病理学和组织学专业知识至关重要。除了所有已出售肿瘤的持续银行外，PBS还提供了研究人员特定的组织采购和加工；访问超过7,000 冷冻的肿瘤样品，其中5,900个与同一患者的正常组织配对；并使用解剖病理学实验室的福尔马林固定石蜡包裹（FFPE）标本档案，该档案由具有各种病理诊断的1,260,000多个FFPE组织块组成。 PBSS对冷冻样本库进行搜索和手术病理档案库，以备针对特定样品集 随后通过DRS检索标本并确认了相关病变/肿瘤的存在。 Olgaloffe或William Twaddell。根据特定的研究问题，可根据要求提供临床病理参数的提供。 PBSS员工在广泛的技术方面拥有丰富的经验 和标本类型。 PBSS与病理学家提供协议开发和组织评估的咨询；机构审查委员会问题；技术支援;以及研究标本，数字图像分析和组织微阵列结构的常规组织学和免疫组织化学分析的专业知识。 PBSS的成功和有效性是基于其整合其病理和 在UMGCC进行研究的生物验证资源和专业知识。