Center for Critical Assessment of Structure Prediciton

结构预测批判评估中心

• 批准号: 8230386
• 负责人: KRZYSZTOF A FIDELIS
• 金额: $ 54.45万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8230386
• 关键词: Academia; Address; Amino Acid Sequence; Area; Beds; Biochemical Pathway; Biological Process; Biology; California; Categories; Collection; Communities; Computational Biology; Computer Simulation; Computer software; Crystallography; Data; Databases; Development; Disease; Drug Design; Educational Curriculum; Educational process of instructing; Effectiveness; Evaluation; Goals; Human; Individual; Investigation; Knowledge; Laboratories; Medicine; Membrane Proteins; Methodology; Methods; Modeling; Molecular Structure; Monitor; NMR Spectroscopy; Peptide Sequence Determination; Performance; Physics; Play; Process; Proteins; Publications; RNA; Relative (related person); Research; Research Infrastructure; Research Personnel; Resources; Rest; Role; Running; Seasons; Source; Staging; Stream; Structure; Students; System; Techniques; Testing; Time; Universities; Work; base; experience; human disease; insight; interest; macromolecule; meetings; method development; operation; programs; protein structure; public health relevance; research study; teacher; tool; web site

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Project Summary (no changes): The primary goal of this project is to provide the infrastructure for the Critical Assessment of Structure Prediction (CASP) program, dedicated to the objective evaluation of macromolecular structure modeling methods. Extensive knowledge of protein and RNA structures will significantly aid the investigation of macromolecular function, interactions, and biochemical pathways. It will also have a major impact on the understanding of biology and human disease, and eventually on drug design. Experimental determination of structure is inherently time-consuming and costly. For macromolecules that have not been addressed by experiment, a computational modeling approach often provides an alternative. Modeling methods, however, are continually evolving and vary in their effectiveness. The CASP process was established to answer two main questions: First, what level of modeling quality can be expected of these techniques? And second, which methods offer the most promise for continued development? CASP is a community-wide program, with over 200 research groups world-wide submitting over 85,000 predictions in the last round. Our group is the primary infrastructure resource for CASP, and handles processing of predictions, develops and implements evaluation software, performs prediction assessment, develops analysis and display tools, and facilitates access to predictions and their evaluation data. We propose to support the current biennial operation of CASP and to expand it by the addition of assessments performed on a continuing basis. To increase the supply of interesting modeling targets we will systematically broaden the network of collaborating crystallography and NMR spectroscopy research groups, including new centers dedicated to the determination of structure of membrane proteins. The expanded network will also be capable of providing the still rare RNA structures, allowing extension of CASP to the assessment of RNA structure modeling. To help overcome the most significant obstacles to progress in structure prediction, we will add a class of specialized assessments focused on specific stages of the modeling process, providing a means of evaluating the performance of these individual steps. Finally, we will place special emphasis on interactions with teachers and researchers throughout academia, with the goal of disseminating the insights and wealth of data gained through CASP.

在此处输入文本，该文本是您的应用程序的新摘要信息。此部分必须没有 文本长度超过 30 行。 项目摘要（无变化）： 该项目的主要目标是为结构的关键评估提供基础设施 预测（CASP）程序，致力于大分子结构建模的客观评价 方法。丰富的蛋白质和 RNA 结构知识将极大地帮助研究 大分子功能、相互作用和生化途径。也将产生重大影响 对生物学和人类疾病的理解，以及最终对药物设计的理解。实验性的 结构的确定本质上是耗时且昂贵的。对于没有的大分子 对于通过实验解决的问题，计算建模方法通常提供一种替代方案。 然而，建模方法在不断发展，其有效性也各不相同。 CASP 流程 建立这个模型是为了回答两个主要问题：首先，建模质量的预期水平是多少？ 这些技术？其次，哪些方法最有希望持续发展？ CASP 是一个社区范围的计划，全球有 200 多个研究小组提交了超过 85,000 上一轮的预测。我们的团队是 CASP 的主要基础设施资源，负责处理 处理预测、开发和实施评估软件、执行预测 评估，开发分析和显示工具，并促进访问预测及其结果 评价数据。我们建议支持 CASP 目前每两年一次的运作，并通过 添加持续进行的评估。增加有趣造型的供给 我们将系统地扩大晶体学和核磁共振的合作网络 光谱学研究小组，包括致力于确定结构的新中心 膜蛋白。扩展后的网络还将能够提供仍然稀有的 RNA 结构，允许将 CASP 扩展到 RNA 结构建模的评估。帮助克服 结构预测进展的最重大障碍，我们将添加一类专门的 评估侧重于建模过程的特定阶段，提供了评估模型的方法 这些单独步骤的性能。最后，我们将特别强调与 整个学术界的教师和研究人员，其目标是传播见解和财富 通过 CASP 获得的数据。