Training Program in Neural Repair

神经修复培训计划

• 批准号: 8261395
• 负责人: MARIE-FRANCOISE S CHESSELET
• 金额: $ 4.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8261395
• 关键词: Training Programs; relating to nervous system; repaired

Since 1998, the Training Program in Neural Repair at UCLA has enabled a collaborative effort of Faculty with broad expertise in neural repair to provide in depth training in this expanding area of Neuroscience. This application requests support to pursue this program with expanded emphasis on training in skills that are made necessary by the evolution of our field. Our trainees will be schooled not only in the basic principles of neural development and response to injury but also in teamwork, innovative technical approaches, and the challenges of translating this basic understanding into benefits for patients. The training program will continue to draw on the unique strength of a group of faculty actively engaged in basic and clinical research on various aspects of Neural Repair at UCLA. Mentors for the program include established and junior investigators with expertise in stem cell differentiation, cell death and neuroprotection, neural development, plasticity and restoration of function after injury to the central nervous system. They include basic and clinical scientists, many of whom bridge the gap between the laboratory and advances in therapies for neurodegenerative diseases and brain injury. All have vigorous research programs and an active commitment to graduate and post-doctoral education. Graduate students in the training program obtain their degree in the Interdepartmental Graduate Program in Neuroscience or one of the ACCESS biomedical graduate programs at UCLA. The curriculum includes training in broad areas of cellular, molecular and system neuroscience, specialized courses in Neural Repair, weekly meetings with other trainees and faculty, seminars from renowned investigators in the field, and exposure to clinical research linked to advances in the field of neural repair. The trainees are encouraged to explore areas at the junction of multiple fields, to use multiple technical approaches, and to engage in collaborations between laboratories. Our goal is to train a cadre of young investigators that are fully prepared for the changing culture of science while retaining a solid background in their main area of expertise. This training approach will benefit from a history of fruitful collaborations and interactions among the mentors in the program and will continue to produce a cadre of young investigators with the ability to respond to the challenges of reducing the burden of disability resulting from degeneration and disruption of the central nervous system.

自 1998 年以来，加州大学洛杉矶分校的神经修复培训计划使教职员工通力合作 拥有神经修复方面广泛的专业知识，可以在这一不断扩展的神经科学领域提供深入的培训。这 申请请求支持以实施该计划，并进一步强调以下技能的培训： 由于我们领域的发展而变得必要。我们的学员不仅将接受基本原则的教育 神经发育和对损伤的反应，还包括团队合作、创新技术方法和 将这种基本理解转化为患者受益的挑战。该培训计划将 继续发挥一批积极从事基础和临床研究的教师队伍的独特优势 加州大学洛杉矶分校神经修复的各个方面。该计划的导师包括知名人士和初级导师 具有干细胞分化、细胞死亡和神经保护、神经发育专业知识的研究人员， 中枢神经系统损伤后的可塑性和功能恢复。它们包括基础和临床 科学家，其中许多人弥合了实验室与治疗进展之间的差距 神经退行性疾病和脑损伤。所有这些都拥有积极的研究计划和积极的 致力于研究生和博士后教育。参加培训计划的研究生获得 神经科学跨部门研究生项目或 ACCESS 生物医学项目之一的学位 加州大学洛杉矶分校的研究生课程。课程包括细胞、分子和等广泛领域的培训 系统神经科学、神经修复专业课程、与其他学员和教职员工的每周会议， 来自该领域著名研究人员的研讨会，并接触与进展相关的临床研究 神经修复领域。鼓励学员探索多个领域交界的领域， 使用多种技术方法，并参与实验室之间的合作。我们的目标是训练 一支年轻的研究人员队伍，他们为不断变化的科学文化做好了充分准备，同时保留了 在其主要专业领域拥有扎实的背景。这种培训方法将受益于 该计划的导师之间富有成效的合作和互动，并将继续产生 有能力应对减轻残疾负担挑战的年轻研究人员队伍 由中枢神经系统退化和破坏引起。

项目成果

Neuronal P2X2 receptors are mobile ATP sensors that explore the plasma membrane when activated.

• DOI: 10.1523/jneurosci.3362-11.2011
• 发表时间: 2011-11-16
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience
• 作者: Richler E;Shigetomi E;Khakh BS
• 通讯作者: Khakh BS

Neuronal regulation of pre-mRNA splicing by polypyrimidine tract binding proteins, PTBP1 and PTBP2.

• DOI: 10.3109/10409238.2012.691456
• 发表时间: 2012-07
• 期刊: Critical reviews in biochemistry and molecular biology
• 影响因子: 6.5
• 作者: Keppetipola N;Sharma S;Li Q;Black DL
• 通讯作者: Black DL

Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types.

• DOI: 10.1186/1749-8104-7-19
• 发表时间: 2012-06-08
• 期刊: Neural development
• 影响因子: 3.6
• 作者: Villegas R;Martin SM;O'Donnell KC;Carrillo SA;Sagasti A;Allende ML
• 通讯作者: Allende ML

Identification of a cis-acting element that localizes mRNA to synapses

• DOI: 10.1073/pnas.1116269109
• 发表时间: 2012-03-20
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Meer, Elliott J.;Wang, Dan Ohtan;Martin, Kelsey C.
• 通讯作者: Martin, Kelsey C.

Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling.

• DOI: 10.1371/journal.pbio.1000446
• 发表时间: 2010-08-10
• 期刊: PLoS biology
• 影响因子: 9.8
• 作者: Palmesino E;Rousso DL;Kao TJ;Klar A;Laufer E;Uemura O;Okamoto H;Novitch BG;Kania A
• 通讯作者: Kania A