Biological Motion Perception in Parkinson's Disease

帕金森病的生物运动感知

• 批准号: 8455560
• 负责人: Abhishek Jaywant
• 金额: $ 4.07万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-24 至 2015-09-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8455560
• 关键词: Accounting; Activities of Daily Living; Adult; Affect; Age; Asperger Syndrome; Biological; Caregivers; Clinical; Code; Control Groups; Coupling; Cues; Data; Discrimination; Disease; Effectiveness; Effectiveness of Interventions; Elderly; Emotions; Freezing; Frequencies; Functional disorder; Gait; Goals; Home environment; Human; Human body; Impairment; Individual; Intervention; Kinesiology; Knowledge; Laboratories; Laws; Lead; Leg; Length; Life; Light; Limb structure; Link; Locomotion; Measures; Mediating; Mentors; Methods; Monitor; Motion; Motion Perception; Motor; Motor Cortex; Movement; Neurodegenerative Disorders; Paraplegia; Parietal Lobe; Parkinson Disease; Parkinsonian Disorders; Patient Self-Report; Patients; Pattern; Perception; Population; Quality of life; Randomized; Rehabilitation therapy; Research; Research Personnel; Rotation; Social Functioning; Speed; Stimulus; Stroke; Techniques; Testing; Training; Visual; Visual Perception; Visual impairment; Walkers; Walking; arm; base; cognitive change; design; evidence base; frontal lobe; improved; innovation; motion sensitivity; motor deficit; neglect; new technology; novel; relating to nervous system; social; visual motor

DESCRIPTION (provided by applicant): Parkinson's disease (PD) is a neurodegenerative disorder that leads to deficits in both visual perception and locomotion. Research to date has neglected to determine whether PD affects the perception of a unique and important visual cue, that of human body motion (biological motion). PD patients' ability to perceive biological motion may be tied to their locomotion deficits, a link suggested by a common coding system between motor function and action perception that is mediated by frontal, motor, and parietal cortices known to be dysfunctional in PD. This perception-action link also suggests that visual training using human motion may be effective in rehabilitating the locomotion deficits in PD. The goals of the proposed study are to investigate biological motion perception and its relation to locomotion in PD (Aim1), and to determine whether visual training using biological motion can improve locomotion deficits in PD (Aim 2). Aim 1 will measure PD patients' sensitivity to perceiving biological motion characterized by different walking speeds and locomotion patterns. The hypotheses are that PD patients will be impaired at perceiving healthy (faster) walking speeds and locomotion patterns, and that patients' locomotion deficits will significantly predict the extet of their impairment in biological motion perception. Aim 2 will use a visual training paradigm that will help patients to discriminate between abnormal, inefficient locomotion and healthy, efficient locomotion. Patients' locomotion will be measured naturalistically at home using activity monitoring in order to determine whether the visual training leads to functional changes in locomotion in patients' daily lives. Together, these goals will enable researchers and clinicians to better understand how PD affects the visual analysis of other humans and their actions, a perceptual ability that is critical to effective social functioning. It will also allow researchersto elucidate the perception-action link in PD, including the specific relation between real-world locomotion and biological motion perception, and how this is affected by PD-related neural dysfunction. Finally, it will provide data regarding the effectiveness of a novel intervention that may improve patients' disordered locomotion. These data will be critically important in establishing whether visual training can be used as a rehabilitation technique in PD that would improve patients' natural walking ability in daily life. PUBLIC HEALTH RELEVANCE: Parkinson's disease leads to deficits in visual and motor abilities that can negatively affect patients' quality of life, and this research will increase knowledge on how individuals with Parkinson's disease perceive human body movements and how this ability is affected by their own limitations in producing body movements. This research will also attempt to study whether patients' walking difficulties can be improved by training them to visually differentiate between normal and impaired walking. The knowledge gained will allow patients and their caregivers to better understand visual and motor deficits in Parkinson's disease and provide important evidence about the effectiveness of an intervention that can improve the debilitating motor limitations that patients suffer from.

描述（由申请人提供）：帕金森氏病（PD）是一种神经退行性疾病，导致视觉感知和运动缺陷。迄今为止的研究忽略了，以确定PD是否影响了人体运动的独特和重要视觉提示的感知（生物运动）。 PD患者感知生物运动的能力可能与他们的运动缺陷有关，这是由运动功能和动作感知之间的常见编码系统所暗示的，该连接是由额叶，运动和顶叶皮层介导的，已知在PD中功能障碍。这种感知性链接还表明，使用人类运动的视觉训练可能有效地修复PD中的运动缺陷。拟议的研究的目标是研究生物运动感知及其与PD运动的关系（AIM1），并确定使用生物运动的视觉训练是否可以改善PD中的运动缺陷（AIM 2）。 AIM 1将测量PD患者对以不同的步行速度和运动模式为特征的感知生物运动的敏感性。假设是，在感知健康（更快）的步行速度和运动模式时，PD患者将受到损害，并且患者的运动缺陷将显着预测其在生物运动感知中的损害。 AIM 2将使用视觉训练范式 将帮助患者区分异常，效率低下的运动和健康，有效的运动。患者的运动将在家中使用活动监测以自然主义的方式进行测量，以确定视觉训练是否导致患者日常生活的运动功能变化。这些目标共同使研究人员和临床医生能够更好地了解PD如何影响其他人类及其行为的视觉分析，这对于有效的社会功能至关重要。它还将允许研究巨星阐明PD中的感知性链接，包括现实世界运动和生物运动感知之间的特定关系，以及如何受PD与PD相关的神经功能障碍的影响。最后，它将提供有关新颖干预措施有效性的数据 可能会改善患者的运动失调。这些数据对于确定视觉训练是否可以用作PD中的康复技术至关重要，从而可以提高患者在日常生活中的自然步行能力。 公共卫生相关性：帕金森氏病导致视觉和运动能力的缺陷，可能会对患者的生活质量产生负面影响，这项研究将增加有关帕金森氏病的人如何感知人体运动以及这种能力如何受到自身产生身体运动的局限性的知识。这项研究还将尝试研究患者的步行困难是否可以通过训练他们在正常和受损的步行中进行视觉区分来改善。所获得的知识将使患者及其护理人员能够更好地了解帕金森氏病的视觉和运动缺陷，并提供有关可以改善患者遭受衰弱的运动限制的干预措施有效性的重要证据。