National Biomedical NMR Resource at Madison

麦迪逊国家生物医学 NMR 资源

• 批准号: 8235825
• 负责人: JOHN LUTE MARKLEY
• 金额: $ 120.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8235825
• 关键词: Area; Automation; Automobile Driving; Binding; Biological; Biological Factors; Biomolecular Nuclear Magnetic Resonance; Cell Extracts; Chemicals; Communities; Complex; Computer software; Consult; Data; Data Analyses; Data Collection; Databases; Deposition; Documentation; Educational workshop; Environmental Risk Factor; Evaluation; Feasibility Studies; Genetic; Goals; Health; Human; Human Resources; Investigation; Knowledge; Label; Liquid Chromatography; Liquid substance; Magnetic Resonance; Manuscripts; Membrane Proteins; Methodology; Methods; Modeling; NMR Spectroscopy; Newsletter; Nuclear Magnetic Resonance; Nucleic Acids; Pharmaceutical Preparations; Physiologic pulse; Preparation; Process; Production; Proteins; Protocols documentation; Publications; Qualifying; RNA; Recovery; Research; Research Activity; Research Personnel; Resources; Sampling; Scientist; Screening procedure; Services; Site; Software Tools; Solutions; Structure; System; Technology; Tissues; Training; Validation; Visit; Work; base; biological systems; cost; data structure; design; experience; frontier; high throughput analysis; instrumentation; lectures; meetings; metabolomics; molecular dynamics; new technology; novel; posters; programs; protein complex; protein structure; research and development; research study; small molecule; software development; technology development; three dimensional structure; tool; web site

The National Magnetic Resonance Facility at Madison (NMRFAM) is a resource for biomolecular nuclear magnetic resonance (NMR) spectroscopy. NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches to metabolomics and natural product analysis. NMRFAM strives to be a model to the larger biological community for cutting-edge capabilities of NMR spectroscopy. With the goal of broadening the scope of its scientific activities, NMRFAM hosts distinguished visiting scientists working in areas related to its research technology and development projects. NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations and offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, and (7) manuscript preparation. NMRFAM provides researchers with resources matched to their particular needs in their search for new knowledge. A major goal is to develop methods for making these investigations faster and less costly as well as applicable to larger classes of proteins and nucleic acids of importance in human health. NMRFAM provides young investigators and experienced spectroscopists access to state-of-the-art instrumentation with support for multiple modes of data collection either as service or collaborative projects. Protocols, pulse sequences, software tools, and databases developed through NMRFAM's research activities are made available to the general scientific community. Users receive hands-on training at the center. As another means for training its user base and for disseminating its novel technology, NMRFAM conducts annual workshops and group training sessions. Additional mechanisms used to disseminate NMRFAM technology include quarterly newsletters, the NMRFAM website, software servers, a metabolomics database, presentations at meetings, and the publication of articles and reviews.

麦迪逊（NMRFAM）的国家磁共振设施是生物分子核磁共振（NMR）光谱的资源。 NMRFAM aims to expand the frontiers of biomolecular NMR spectroscopy through resource technology and development programs in the important areas of (1) high-throughput determination of structures and functions of smaller proteins and RNA molecules, (2) technology for investigating the structure and dynamics of challenging systems, including complexes, membrane proteins, paramagnetic proteins, and larger RNA molecules, and (3) efficient approaches代谢组学和自然产品分析。 NMRFAM致力于成为更大的生物群落的模型，以实现NMR光谱的最先进能力。为了扩大其科学活动的范围，NMRFAM主持了与研究技术和开发项目有关的领域工作的杰出访问科学家。 NMRFAM develops and disseminates advanced approaches that cover all steps in biomolecular NMR investigations and offers start-to-finish support for biomedical NMR investigations with assistance in one or more of the following steps: (1) strategy evaluation and experiment design, (2) sample preparaton, (3) feasibility studies, (4) data collection, (5) data analysis and structure determination, (6) data validation and deposition, and (7)手稿准备。 NMRFAM为研究人员提供了符合其特定需求的资源，以寻找新知识。一个主要目标是开发使这些研究更快，成本较低的方法，并且适用于在人类健康中具有重要意义的较大类别的蛋白质和核酸。 NMRFAM为年轻的研究人员和经验丰富的谱学家访问最先进的仪器，并支持多种数据收集作为服务或协作项目的模式。通过NMRFAM的研究活动开发的协议，脉冲序列，软件工具和数据库可供普通科学界提供。用户在中心接受动手培训。作为培训其用户群和传播其新技术的另一种手段，NMRFAM进行了年度研讨会和小组培训课程。用于传播NMRFAM技术的其他机制包括季度新闻通讯，NMRFAM网站，软件服务器，代谢组学数据库，会议上的演示以及文章和评论的发表。