Molecular and Cellular Biology & Biochemistry and Structural Biology Graduate Tra

分子和细胞生物学

• 批准号: 8214293
• 负责人: Robert S. Haltiwanger
• 金额: $ 13.18万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8214293
• 关键词: Biochemistry; Molecular and Cellular Biology; structural biology

DESCRIPTION (provided by applicant): The goal of the Molecular, Cellular, and Structural Biology (MCSB) Training Program is to provide outstanding pre-doctoral training on a wide variety of topics involving basic biological and biomedical processes at the molecular and cellular level. The training in biochemistry, molecular biology, cell biology, and structural bioloy emphasized in this program will help to generate the next generation of basic scientists in this country. The training program offers a multidisciplinary course of study leading to the Ph.D. degree and provides students with the opportunity to select one of four specializations: Biochemistry and Molecular Biology; Cellular and Developmental Biology; Immunology and Pathology; and Structural Biology. During the first year all students enroll in core courses including Graduate Biochemistry, Molecular Genetics, and/or Graduate Cell Biology. Depending on their academic specialization future courses include Structural Biology and Spectroscopy, Cell and Developmental Biology, or Immunology and General Pathology. Students also initially receive training to critically evaluate original research articles in a Journal Club. In addition, hey gain teaching experience as Teaching Assistants in undergraduate biology laboratories. In subsequent years they gain additional experience in oral presentation by giving 30-minute seminars on their research to the entire graduate program. Three to four laboratory training experiences, or rotations, serve to help the student to select a mentor for her/his thesis research at completion of her/his first academic year. The MCSB program is quite diverse, crossing departmental and institutional boundaries to offer thesis research training in 72 different mentored laboratories at three institutions: Stony Brook University, Brookhaven National Laboratory, or Cold Spring Harbor Laboratory. There are currently 101 students in the program with approximately 20 admissions per year. Four of the top first year students will be selected by the Executive Committee to be supported as NIH predoctoral trainees for their second year. Assuming the student continues to progress well (as determined by course work, qualifying exam results, and recommendation of the mentor) support can be renewed for their third year. Thus, a total of eight students will be supported each year (four second-year students, and four third-year students). Second year students are required to pass a written qualifying exam. Subsequently, the students present yearly reports on their research progress in a seminar forum to other graduate students, postdoctoral fellows, and faculty. In the third year of the program students prepare a proposal on their intended research project and defend the proposal before a faculty committee. Following successful defense of the proposal, students advance to candidacy and the faculty thesis committee monitors the students' progress until successful completion of the project and defense of a written doctoral thesis. PUBLIC HEALTH RELEVANCE: The goal of the Molecular, Cellular, and Structural Biology (MCSB) Training Program is to provide outstanding pre-doctoral training to the next generation of basic scientists in this country. The importance of basic research to a deeper understanding of human diseases cannot be overstated and provides an essential first step towards all translational medicine, as pointed out by Bruce Alberts in a recent Science editorial (Model Organisms and Human Health, Science 330, 1724).

描述（由申请人提供）：分子、细胞和结构生物学（MCSB）培训计划的目标是提供出色的博士前培训，涉及分子和细胞水平的基本生物和生物医学过程的各种主题。该项目强调的生物化学、分子生物学、细胞生物学和结构生物学方面的培训将有助于培养该国的下一代基础科学家。该培训计划提供多学科的学习课程，最终获得博士学位。学位，并为学生提供选择四个专业之一的机会：生物化学和分子生物学；细胞与发育生物学；免疫学和病理学；和结构生物学。在第一年，所有学生都会注册核心课程，包括研究生生物化学、分子遗传学和/或研究生细胞生物学。根据他们的学术专业，未来的课程包括结构生物学和光谱学、细胞和发育生物学、或免疫学和普通病理学。学生最初还接受培训，在期刊俱乐部中批判性地评估原创研究文章。此外，他们还可以在本科生物实验室担任助教，获得教学经验。在随后的几年中，他们通过为整个研究生课程举办 30 分钟的研究研讨会，获得了口头演讲的额外经验。三到四次实验室培训经验或轮换有助于学生为她/他的论文研究选择导师 在她/他的第一学年完成时。 MCSB 项目相当多样化，跨越部门和机构界限，在石溪大学、布鲁克海文国家实验室或冷泉港实验室这三个机构的 72 个不同指导实验室提供论文研究培训。目前该项目有 101 名学生，每年约有 20 名学生入学。执行委员会将选出四名一年级的顶尖学生，作为第二年的 NIH 博士前培训生提供支持。假设学生继续取得良好进展（根据课程作业、资格考试成绩和导师的推荐确定），可以在第三年续签支持。因此，每年将资助总共八名学生（四名二年级学生和四名三年级学生）。二年级学生必须通过笔试资格考试。随后，学生们在研讨会论坛上向其他研究生、博士后研究员和教师提交年度研究进展报告。在该项目的第三年，学生准备一份关于他们预期研究项目的提案，并在教员委员会面前捍卫该提案。成功通过提案答辩后，学生将获得候选资格，教师论文委员会将监督学生的进展，直到成功完成项目并通过书面博士论文答辩。 公共卫生相关性：分子、细胞和结构生物学 (MCSB) 培训计划的目标是为我国下一代基础科学家提供出色的博士前培训。正如 Bruce Alberts 在最近的《科学》社论中指出的那样，基础研究对于更深入地了解人类疾病的重要性怎么强调都不为过，并且为所有转化医学提供了重要的第一步（模型生物和人类健康，科学 330, 1724）。