Countermeasures to cardiovascular impairment during circadian misalignment

昼夜节律失调期间心血管损害的对策

基本信息

批准号：
10802104
负责人：
Sophie Seward
金额：
$ 3.57万
依托单位：
COLORADO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-26 至 2024-08-25
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10802104
关键词：
Abdomen Achievement Acute Adult Behavior Behavioral Biological Blood Pressure Blood Vessels Calories Cardiovascular Diseases Cardiovascular Physiology Cardiovascular system Chronic Disease Circadian Dysregulation Circadian Rhythms Circadian desynchrony Clinical Consumption Cross-Over Studies Data Development Diastolic blood pressure Diet Disease Management Eating Energy Intake Environmental Risk Factor Fasting Fatty acid glycerol esters Forearm Functional disorder Funding Future Glucose Goals Healthcare Heart Rate Hour Hypertension Impairment Individual Inpatients Insulin Resistance International Intervention Jet Lag Syndrome Knowledge Laboratories Light Link Lipids Measures Mediating Medical Residency Mentorship Metabolic Metabolic Diseases Methodology Military Personnel Modernization Non-Insulin-Dependent Diabetes Mellitus Nurses Obesity Paramedical Personnel Persons Physiology Pilot Projects Plasma Police Population Populations at Risk Prediabetes syndrome Protocols documentation Publications Randomized Research Research Design Risk Risk Factors Rotation Savings Scientist Sleep Sleep Deprivation Sleep Disorders Sleep disturbances Societies System Testing Time Time-restricted feeding Training Visual Visualization Weight Gain Woman Work blood pressure elevation cardiometabolism cardiovascular disorder prevention cardiovascular disorder risk cardiovascular health cardiovascular risk factor circadian combat cost effective diabetes risk disorder prevention disorder risk emergency service responder fasting glucose fire fighter high risk improved intrahepatic meetings men prevent programs reactive hyperemia research and development response risk mitigation shift work skills translatable strategy vasoconstriction

项目摘要

PROJECT SUMMARY People who work evening, night or rotating shifts (i.e. “nonstandard” work hours) make up 20% of the US workforce, have a 17% higher risk of cardiovascular disease (CVD) compared to people who work days. Sleep and circadian misalignment are two mechanism suggested to increases the risk of CVD in people who work non-standard hours, and is highly prevalent and often unavoidable in modern, 24-hour society (e.g. shift work, long work hours, jet lag, medical residency, emergency responders, military personnel, Daylight Savings Time changes, etc). Disruptions in sleep and circadian rhythms have been linked to insulin resistance, increased energy intake, weight gain, and increased total body, abdominal and intrahepatic fat content, yet there have been limited attempts at identifying strategies or countermeasures to prevent the impact of such disruption on CVD risk in a sizeable proportion of the population. Therefore, our long-term goal is to identify and develop effective, behavioral countermeasures to combat the increased risk for metabolic diseases associated with sleep and circadian disruption when these behaviors are unavoidable. The overall objective for this project is to test the impact of time-restricted feeding to a 7h period in the day as a noninvasive countermeasure to the metabolic impairments associated with circadian misalignment. Our central hypothesis is that time-restricted feeding to the daytime period will prevent cardiovascular impairments during circadian misalignment compared to a condition where energy is consumed throughout the day and night. The rationale for the proposed project is that defining a non-invasive, scalable and feasible countermeasure to circadian misalignment could mitigate the risk of cardiovascular disease. To test our overall hypothesis, will use a randomized crossover study with a rigorous inpatient diet-, activity and light-controlled protocol in 32 healthy men and women. We will determine the impact of time- restricted feeding during circadian misalignment on 1) 24h blood pressure; and 2) vascular function. Findings from this study represent a critical advancement in the fields of translational circadian and metabolic physiology by identifying and testing a countermeasure to circadian misalignment. Achievement of our proposed aims could lead to the development of new intervention strategies for chronic disease prevention and management. The knowledge to be gained offers the potential to support cost-effective programs that may inform our healthcare approach to cardiovascular disease prevention in populations at risk for these diseases such as shift workers, individuals with sleep disorders and anyone who eats outside of daytime hours.

项目概要上晚班、夜班或轮班（即“非标准”工作时间）的人占 20% 与工作日的人相比，美国劳动力患心血管疾病 (CVD) 的风险高出 17%。睡眠和昼夜节律失调是增加以下人群患 CVD 风险的两种机制：非标准时间工作在现代 24 小时社会中非常普遍且往往不可避免（例如轮班）工作、长时间工作、时差、住院医师、紧急救援人员、军事人员、夏令时睡眠和昼夜节律的紊乱与胰岛素抵抗有关，能量摄入增加，体重增加，全身、腹部和肝内脂肪含量增加，但在确定防止此类影响的战略或对策方面的尝试有限。降低相当大一部分人口的 CVD 风险。因此，我们的长期目标是确定和制定有效的行为对策对抗与睡眠和昼夜节律紊乱相关的代谢疾病风险增加该项目的总体目标是测试限时喂养的影响。一天中的 7 小时作为一种无创对策来应对与我们的中心假设是，白天限时喂食可以防止昼夜节律失调。与消耗能量的情况相比，昼夜节律失调期间的心血管损害拟议项目的基本原理是定义一个非侵入性的、可扩展的。昼夜节律失调的可行对策可以降低心血管疾病的风险。为了检验我们的总体假设，将使用随机交叉研究和严格的住院饮食，我们将确定 32 名健康男性和女性的活动和光控方案的影响。在 1) 24 小时血压和 2) 血管功能昼夜节律失调期间限制进食。这项研究的结果代表了转化昼夜节律和通过识别和测试昼夜节律失调的对策来实现代谢生理学。我们提出的目标可能会导致制定新的慢性病预防干预策略获得的知识有可能支持具有成本效益的计划。告知我们针对心血管疾病高危人群预防心血管疾病的医疗保健方法例如轮班工人、有睡眠障碍的人以及任何在白天以外进食的人。