Advancement of the Xiphophorus Model for Studying Disease

研究疾病的剑尾动物模型的进展

基本信息

批准号：
10805701
负责人：
Yuan Lu
金额：
$ 22.59万
依托单位：
TEXAS STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-01 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10805701
关键词：
Address Adult Ammonia Anaerobic Bacteria Animal Experimentation Animals Beds Behavioral Bioinformatics Biological Biological Models Biomedical Research Body Size Cancer Etiology Chronobiology Communities Cryopreservation Custom Data Development Disease Embryo Ensure Female Fishes Generations Genetic Genome Genomics Growth Hybrids Immunologics Institution Lead Link Manuals Mechanics Metabolism Mission National Human Genome Research Institute National Institute of Allergy and Infectious Disease National Institute of Child Health and Human Development National Institute of Diabetes and Digestive and Kidney Diseases National Institute of Environmental Health Sciences National Institute of General Medical Sciences Nitrites Optics Parasitology Personal Satisfaction Physiological Plants Production Protocols documentation Regulation Reproducibility Reproduction Research Resources Sampling Services Shock Stress Study models Swimming System Texas Toxicology United States National Institutes of Health Universities Variant Water Xiphophorus aquarium bioinformatics resource density dietary genetic resource improved inter-individual variation male meter model organism sex determination sperm cell trait ultraviolet water flow water quality

项目摘要

Project Summary The Xiphophorus Genetic Stock Center (XGSC) is the only national resource center for the Xiphophorus model system. It provides animals, biological samples, genomics, husbandry, disease and bioinformatics resources to the biomedical research community at large. It resides at Texas State University and has actively served the research community since 1993. Currently, the Xiphophorus are housed in static aquarium of different sizes. While functional, this set up leads to concerns over water quality, and its consistency across different aquariums. Additionally, static water can influence normal Xiphophorus development. We propose to purchase and install a re-circulating system to be used for maintaining and reproducing Xiphophorus to address these issues and aim to improve husbandry conditions for all species housed in the XGSC, in order to strength the rigor and reproducibility of the research animals for the biomedical research community users.

项目概要剑尾鱼遗传资源中心（XGSC）是唯一的国家剑尾鱼资源中心模型系统。它提供动物、生物样本、基因组学、畜牧业、疾病和生物信息学为整个生物医学研究界提供资源。它位于德克萨斯州立大学，并拥有自 1993 年以来积极为研究界服务。目前，剑尾鱼被安置在静态的环境中。不同大小的水族箱。虽然功能齐全，但这种设置会导致人们对水质及其影响的担忧。不同水族馆之间的一致性。此外，静止的水会影响正常的剑尾鱼发展。我们建议购买并安装一个再循环系统，用于维护和繁殖剑尾鱼以解决这些问题并旨在改善所有物种的饲养条件安置在 XGSC 中，以加强研究动物的严谨性和可重复性生物医学研究社区用户。