The UNC Chapel Hill Superfund Research Program (UNC-SRP)

北卡罗来纳大学教堂山超级基金研究计划 (UNC-SRP)

基本信息

批准号：
10797455
负责人：
Rebecca Fry
金额：
$ 1.26万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-06-02 至 2024-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10797455
关键词：
Address Amendment Arsenic Authorization documentation Biological Businesses Chemical Exposure Chemistry Collaborations Communication Communities Complex Mixtures Data Analyses Development Diabetes Mellitus Disease Ensure Environmental Science Excision Exposure to Foundations Future Genotype Gestational Age Human In Vitro Individual Industrialization Industry Institution Intervention Knowledge Lead Life Link Mediating Metabolic Diseases Metabolic dysfunction Metal exposure Metals Methods Methyltransferase MicroRNAs Mission Molecular North Carolina Placenta Pollution Population Predisposition Prevalence Prevention Privatization Proteins Public Health Regulation Research Research Personnel Research Project Grants Research Technics Rivers Sampling Science Scientist Signal Recognition Particle Soil Source Southeastern United States Superfund Technology Training Translating Translational Research United States Universities Vision Water Wood material Work authority biomarker identification coal ash community engagement data integration data management diabetes risk disorder prevention disorder risk drinking environmental chemical environmental justice epidemiology study experience exposed human population gut microbiome in vivo Model innovation interdisciplinary approach next generation novel novel strategies prenatal exposure prevent programs rural area superfund site transcription factor vulnerable community

项目摘要

PROJECT DESCRIPTION Summary: While prenatal exposure to environmental metals, such as inorganic arsenic, is associated with decreased gestational age, there is a fundamental knowledge gap regarding the placental molecular drivers of this association. Numerous epidemiological studies have associated exposure to individual environmental metals, such as inorganic arsenic and lead, with decreased gestational age. Often such studies analyze chemical exposures individually instead of in mixtures. This analytical approach does not reflect the fact that humans are exposed to complex mixtures of environmental chemicals that may have interactive or synergistic effects. Ignoring the possibility of these combined effects may obscure the full extent of the association between exposure to environmental metals and gestational age. This project will examine the association between exposure to environmental metals early in life and gestational age. The metals will be analyzed individually as well as a mixture. Subsequently, to identify biological mechanisms underlying this association, we will identify specific miRNAs and proteins within the placenta that may mediate the association between metal exposure and gestational age.

项目描述摘要：虽然产前接触环境金属（例如无机砷）是与胎龄降低相关，在以下方面存在基本知识差距：这种关联的胎盘分子驱动因素。大量流行病学研究表明与个别环境金属（例如无机砷和铅）的相关暴露胎龄降低。通常此类研究会单独分析化学品暴露情况的混合物中。这种分析方法并没有反映出人类暴露于可能具有相互作用或协同效应的环境化学物质的复杂混合物。忽略这些综合影响的可能性可能会掩盖关联的全部范围暴露于环境金属和孕龄之间。该项目将审查生命早期接触环境金属与孕龄之间的关联。这金属将被单独分析以及混合物分析。随后，鉴定生物这种关联的机制，我们将识别特定的 miRNA 和蛋白质胎盘可能介导金属暴露与胎龄之间的关联。

项目成果

期刊论文数量（44）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Analysis of 'Investigating an extended multiphase flow model that includes specific interfacial area', Computer Methods in Applied Mechanics and Engineering, 418:116594, 2024.

“研究包括特定界面区域的扩展多相流模型”的分析，应用力学与工程中的计算机方法，418：116594，2024。

DOI：
发表时间：
2024-06-01
期刊：
影响因子：
7.2
作者：
Gray, William G;Miller, Cass T
通讯作者：
Miller, Cass T

Generation of the Chemical and Social Stressors Integration Technique (CASS-IT) to identify areas of holistic public health concern: An application to North Carolina.

生成化学和社会压力源整合技术 (CASS-IT)，以确定整体公共卫生问题的领域：在北卡罗来纳州的应用。

DOI：
发表时间：
2023-03-01
期刊：
影响因子：
0
作者：
Eaves, Lauren A;Lanier, Paul;Enggasser, Adam E;Chung, Gerard;Turla, Toby;Rager, Julia E;Fry, Rebecca C
通讯作者：
Fry, Rebecca C

Antipsychotic Behavioral Phenotypes in the Mouse Collaborative Cross Recombinant Inbred Inter-Crosses (RIX).

小鼠协作杂交重组近交杂交 (RIX) 中的抗精神病行为表型。

DOI：
发表时间：
2020
期刊：
影响因子：
0
作者：
Giusti;Xenakis, James G;Crowley, James J;Nonneman, Randal J;DeCristo, Daniela M;Ryan, Allison;Quackenbush, Corey R;Miller, Darla R;Shaw, Ginger D;Zhabotynsky, Vasyl;Sullivan, Patrick F;Manuel de Villena, Fernando Pardo;Zou, Fe
通讯作者：
Zou, Fe

Epigenetic Responses to Nonchemical Stressors: Potential Molecular Links to Perinatal Health Outcomes.

对非化学应激源的表观遗传反应：与围产期健康结果的潜在分子联系。