Neurological Emergencies Treatment Trials (NETT) Network

神经急症治疗试验 (NETT) 网络

• 批准号: 7810619
• 负责人: Robert D. Welch
• 金额: $ 19.41万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-03 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7810619
• 关键词: Accident and Emergency department; Acute; Address; Adult; American; Area; Cardiac; Caring; Cerebrum; Cessation of life; Childhood; Clinical; Clinical Research; Clinical Trials; Competence; Computerized Medical Record; Conduct Clinical Trials; Consultations; Critical Care; Data; Disease; Education; Emergency Medicine; Emergency Situation; Emergency treatment; Enrollment; Evaluation; Family; Future; Goals; Health; Hospitals; Hour; Injury; Institutes; Institution; Intervention Trial; Life; Link; Medical; Medical center; Michigan; Minority; Mission; Monitor; Motivation; Nature; Neurologic; Neurological emergencies; Neurologist; Neurology; Neurosciences; Neurosurgeon; Outcome; Oxygen saturation measurement; Patient Care; Patients; Pattern; Phase; Physicians; Principal Investigator; Process; Protocols documentation; Recording of previous events; Rehabilitation therapy; Relative (related person); Research; Research Infrastructure; Research Personnel; Resuscitation; Site; Societies; Specialist; Spinal Extradural Abscess; Study Subject; Surgeon; System; Telemedicine; Testing; Training; Trauma; Uncertainty; Universities; Visit; base; bench to bedside; burden of illness; care systems; clinical research site; community consultation; data management; demographics; design; disability; effective therapy; expectation; experience; improved; interdisciplinary collaboration; medical specialties; nervous system disorder; neurosurgery; patient population; programs; research study; success; treatment trial

DESCRIPTION (provided by applicant): Acute neurologic disorders, relative to their effect on society, have been very poorly studied. Many of these neurological problems require emergent evaluation and treatment, ideally by a multi-disciplinary team. The NETT network has been established to address just these issues as the discovery and implementation of effective treatments for neurological emergencies will require sophisticated study protocols derived from large-scale clinical trials. The success of this initiative hinges not only on a well-coordinated central data management center, but also on hub and spoke sites that have the competence to enroll patients emergently across a large demographic. The broad and long-term goal of this program is to test and institute new effective therapies for neurological emergencies and improve the overall health of Americans. The project design is that of a central coordinating "Hub" (Dept. of Emergency Medicine, Wayne State University - WSU) which has proven expertise in emergency patient care and emergency based clinical trails. The "Spokes" (Detroit Medical Center and William Beaumont Hospitals) offers: i) expertise in the neurosciences from the bench to the bedside, 2) proven competency in enrolling patients into emergent interventional trials, 3) over 500,000 emergency department visits across a wide demographic that blankets Southeast Michigan and 4) a long history of inter-hospital, interdepartmental and interdisciplinary collaboration. Dr Robert Welch, in conjunction with Dr. Brian O'Neil, has an enviable group of established collaborators that include both adult and pediatric emergency medicine physicians, neurologists, neurosurgeons, critical care specialists and trauma surgeons. The WSU "Hub" has a breadth of experience in emergent intervention trials initiated pre-hospital and continued throughout the emergency department, hospital and rehabilitation phases. WSU investigators have successfully enrolled patient in the pre-hospital interventional trials Res-Q, PAD, PolyHeme, DCAR, POST and Cerebral oximetry trials. Furthermore the same investigators have been leaders in enrolled patients in various emergent interventional trials such as RESCUE, TIA-ADP, PECARN, ONO-REACT, BADHIT, Gen-IMS, PROACTION, and RESCUE-ACS. In each of these trials our sites have exceeded expectations and provided high volume and high quality clean data to the principal investigators. A number of these studies required community consultation for implementation. The WSU site is equipped with an integrated and sophisticated electronic medical record system that links hospital sites. The system has advanced telemedicine capabilities, which further augments patient evaluations and consultation. The NETT Network will perform research studies that will ultimately result in new and effective treatment s of neurological emergencies. These new treatments will be disseminated to practicing doctors and their patients and will improve the health and lives of the public.

描述（由申请人提供）：相对于其对社会影响的急性神经系统疾病的研究很差。这些神经系统问题中的许多需要新的评估和治疗，理想情况下是由多学科团队进行的。已经建立了NetT网络以解决这些问题，因为发现和实施神经系统紧急情况的有效治疗方法将需要从大规模临床试验中得出的复杂研究方案。该计划的成功不仅取决于协调良好的中央数据管理中心，而且在集线器和讲话网站上取决于有能力，可以使患者在大型人群中出现。该计划的广泛和长期目标是测试和制定新的有效疗法，以解决神经系统紧急情况，并改善美国人的整体健康状况。项目设计是中央协调“枢纽”（Wayne State University -WSU急诊医学系）的设计，该项目在急诊患者护理和基于急诊的临床踪迹方面已证明了专业知识。 “发言人”（底特律医疗中心和威廉·博蒙特医院）提供：i）从长凳到床边的神经科学领域的专业知识，2）2）在遍布遍布的密歇根州的遍布和4）长期合作的人群中，使患者参与新兴的干预试验，3）超过500,000个急诊室访问，跨越了跨越的跨越历史。罗伯特·韦尔奇（Robert Welch）博士与布莱恩·奥尼尔（Brian O'Neil）博士一起，拥有一群成熟的合作者，包括成人和儿科急诊医学医生，神经病学家，神经外科医生，重症监护专家和创伤外科医生。 WSU“枢纽”在紧急干预试验中具有广泛的经验，并在整个急诊室，医院和康复阶段继续进行。 WSU研究人员已成功地招募患者参加院前介入试验RES-Q，PAD，POLYHEME，DCAR，POST和脑血氧症试验。此外，同一研究人员是参与各种紧急介入试验的患者的领导者，例如救援，TIA-ADP，PECARN，ONO-REACT，BADHIT，BADHIT，GEN-IMS，PROCATION，PRACTION和RESCUE-ACS。在每个试验中，我们的站点都超出了预期，并为主要研究人员提供了高量和高质量的清洁数据。这些研究中有许多需要社区咨询进行实施。 WSU站点配备了连接医院站点的集成且复杂的电子病历系统。该系统具有提高远程医疗功能，进一步增加了患者的评估和咨询。 NETT网络将进行研究，最终将导致神经系统紧急情况的新有效治疗。这些新的治疗方法将被传达给执业医生及其患者，并将改善公众的健康和生活。