Development of Multilayer Strip Ion Chamber Device for the Measurement of Proton FLASH-Radiotherapy

用于测量质子闪光放射治疗的多层条形电离室装置的开发

• 批准号: 10714482
• 负责人: HAO JIANG
• 金额: $ 39.62万
• 依托单位: TETRAIMAGING, LLC
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-16 至 2023-09-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10714482
• 关键词: Algorithmic Software; Characteristics; Charge; Collection; Computer software; Cyclotrons; Development; Devices; Dose; Dose-Rate; Genetic Recombination; Human body; Ions; Measurement; Measures; Modality; Normal tissue morphology; Positioning Attribute; Protons; Radiation Dose Unit; Radiation therapy; Spottings; Synchrocyclotron; Systems Development; Systems Integration; Toxic effect; Validation; cell killing; design; improved; neoplastic cell; proton beam; quality assurance; research study; tool

Ultra-high dose rate radiotherapy or FLASH-RT, has shown the potential to drastically reduce the normal tissue toxicity without compromising tumor cell killing. Proton is the only treatment modality that can treat deep seated target in human body with FLASH-RT. With radiation dose delivered in less than a second, an ultra-fast quality assurance (QA) device is needed to verify the delivery of FLASH-RT. We will develop a multilayer strip ion chamber (MLSIC) device can measure the characteristics of a proton flash beam spot-by-spot including spot position and profile, energy, and absolute dose. The MLSIC device can be used for development, commissioning and QA of proton flash-beams. To develop the MLSIC and achieve the unmet need of QA device for flash-RT, we will perform the research studies to achieve following objectives: 1) Design, optimization, and characterization of a MLSIC device for proton FLASH-RT QA in a synchrocyclotron and an isochronous cyclotron; and 2) Development of proton beam QA algorithm and software for the MLSIC.

超高剂量率放疗或 FLASH-RT 已显示出在不影响肿瘤细胞杀伤的情况下大幅降低正常组织毒性的潜力。 Proton 是唯一可以通过 FLASH-RT 治疗人体深层靶标的治疗方式。由于辐射剂量在不到一秒的时间内传递，因此需要超快的质量保证 (QA) 设备来验证 FLASH-RT 的传递。我们将开发一种多层带状离子室 (MLSIC) 设备，可以逐点测量质子闪光束的特性，包括光点位置和轮廓、能量和绝对剂量。 MLSIC 设备可用于质子闪光束的开发、调试和质量保证。为了开发 MLSIC 并实现 flash-RT QA 设备未满足的需求，我们将进行研究以实现以下目标： 1) 同步回旋加速器中用于质子 FLASH-RT QA 的 MLSIC 设备的设计、优化和表征等时回旋加速器； 2) 为 MLSIC 开发质子束 QA 算法和软件。