1/2 Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC)

1/2 加强 NCCU 和 UNC 酒精研究的合作伙伴关系 (PEAR-NC)

• 批准号: 10705854
• 负责人: Gregory Jay Cole
• 金额: $ 104.55万
• 依托单位: NORTH CAROLINA CENTRAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705854
• 关键词: ARHGEF5 gene; Address; Adolescent; Adult; African American; African American population; African American student; Alcohol abuse; Alcohols; Area; Award; Behavioral; Brain; Collaborations; Core Facility; Course Content; Data; Education; Educational Curriculum; Educational process of instructing; Endowment; Environment; Ethanol toxicity; Faculty; Fetal Alcohol Spectrum Disorder; Funding; Future; Goals; Grant; Health Professional; Historically Black Colleges and Universities; Inflammation; Infrastructure; Institution; Internships; Joints; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Manuscripts; Medical; Medical Libraries; Mentors; Minority; Molecular; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Neuroimmune; North Carolina; Pathology; Preparation; Process; Productivity; Publications; Research; Research Personnel; Research Project Grants; Research Technics; Resource Sharing; Resources; Scholarship; Series; Severities; Structure; Students; Techniques; Tissues; Toxic effect; Training; U-Series Cooperative Agreements; Underrepresented Minority; United States National Institutes of Health; Universities; Work; alcohol exposure; alcohol research; alcohol use disorder; carcinogenesis; career; cellular pathology; expectation; experience; experimental study; faculty mentor; fetal; graduate student; health disparity; improved; interest; laboratory development; laboratory experience; lectures; malignant breast neoplasm; mammary; medical schools; meetings; minority investigator; neuropathology; neurotoxicity; post-doctoral training; programs; recruit; research and development; response; role model; skills; stem cells; success; summer internship; synergism; undergraduate student; underrepresented minority student; university student; virology

This is an application for a cooperative agreement (U54), “Partnerships to Enhance Alcohol Research across NCCU and UNC (PEAR-NC),” between faculties of North Carolina Central University (NCCU), a Historically Black College or University, and the Bowles Center for Alcohol Studies (BCAS) at the University of North Carolina (UNC) School of Medicine. This proposal represents a true collaborative effort between the NCCU and UNC faculty with both groups contributing significant effort and being essential to the success of this Alcohol and Health Disparities program. Within this proposal, an NCCU Administrative Core and three Research Components will integrate with the UNC-BCAS Administrative Research Components, as well as other activities at the Bowles Center for Alcohol Studies. The UNC NIAAA Alcohol Research Center (ARC) and BCAS have many faculty studying mechanisms of alcohol pathology across the spectrum of behavioral, tissue, and cellular pathologies that occur with alcohol exposure. This proposal will focus on cellular pathologies that allow collaborative research partnerships on common areas of interest between UNC and NCCU faculty. These partnerships open UNC research laboratories, core facilities, and medical libraries to NCCU faculty, improving opportunities for developing productive research laboratories at NCCU. In addition, due to recent NCCU NIAAA R awards, large numbers of NCCU students will continue to become involved in research on mechanisms of alcohol pathology, providing education on African American alcohol-related health disparities which are due to increased morbidity to alcohol-related pathologies and not increased alcohol use disorder. The objective of this U54 partnership is to investigate molecular mechanisms of alcohol-induced cellular pathology. This proposal includes three NCCU research projects, involving six NCCU faculty, that will investigate the molecular mechanisms of fetal alcohol pathology, alcohol-induced mammary stem cell toxicity, and neuroimmune responses in adolescent and adult brain. A second objective is to provide research experiences and scholarly education on alcohol pathology for NCCU students. The educational efforts in this proposal will involve NCCU undergraduate and graduate students through the BCAS seminar series, through training in UNC laboratories and research development and mentor meetings, attendance and presentation of data at the annual RSA meeting, an alcohol seminar series hosted by NCCU, new course curricula on alcohol pathology developed with a focus on health disparities, as well as specific undergraduate student summer internships for NCCU students to study and learn about alcohol pathology and health disparities within laboratories in both institutions. Ultimately, this proposal will conduct, promote, support, and mentor research into mechanisms of alcohol pathology, creating an active and successful alcohol research program within NCCU that synergizes with UNC to advance education and discoveries.

这是一份合作协议 (U54) 的申请，“加强酒精研究的合作伙伴关系” NCCU 和 UNC (PEAR-NC)”，是北卡罗莱纳中央大学 (NCCU) 院系之间的一个历史性项目 布莱克学院或大学，以及北大学鲍尔斯酒精研究中心 (BCAS) 该提案代表了 NCCU 之间真正的合作努力。 和北卡罗来纳大学的教职人员，两个小组都做出了巨大的努力，对本次活动的成功至关重要 在该提案中，酒精与健康差异计划包括一个 NCCU 行政核心和三个 研究部分将与 UNC-BCAS 行政研究部分以及 鲍尔斯酒精研究中心的其他活动 北卡罗来纳大学 NIAAA 酒精研究中心 (ARC) 和 BCAS 拥有许多研究酒精病理学机制的教师，涉及行为、组织、 以及因酒精暴露而发生的细胞病理学 该提案将重点关注以下细胞病理学： 允许 UNC 和 NCCU 教师之间在共同感兴趣的领域建立合作研究伙伴关系。 这些合作伙伴关系向 NCCU 教师开放 UNC 研究实验室、核心设施和医学图书馆， 此外，由于最近的原因，NCCU 的生产性研究实验室的发展机会得到了改善。 国立交通大学NIAAA R奖，大批国立交通大学学生将继续参与相关研究 酒精病理学机制，提供有关非裔美国人酒精相关健康差异的教育 这是由于酒精相关病症的发病率增加，而不是酒精使用障碍的增加。 U54 合作伙伴关系的目的是研究酒精诱导的细胞损伤的分子机制 该提案包括三个国立政治大学研究项目，涉及六名国立政治大学教员。 研究胎儿酒精病理学、酒精诱导的乳腺干细胞毒性的分子机制， 第二个目标是提供研究。 国立政治大学学生酒精病理学的经验和学术教育。 提案将通过 BCAS 研讨会系列让 NCCU 本科生和研究生参与，通过 北卡罗来纳大学实验室培训以及研究开发和导师会议、出席和介绍 RSA年度会议的数据、国立政治大学主办的酒精研讨会系列、酒精新课程 病理学的发展重点是健康差异以及特定的本科生暑期 NCCU 学生实习，学习酒精病理学和健康差异 最终，该提案将开展、促进、支持和指导研究。 深入研究酒精病理学机制，在内部创建积极且成功的酒精研究计划 NCCU 与 UNC 协同推进教育和发现。