CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

化学筛选和优化设施 - 管理、行政和数据库核心功能活动

• 批准号: 10706293
• 负责人: LEYI GONG
• 金额: $ 27.72万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-26 至 2023-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10706293
• 关键词: Agonist; Archives; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Discipline; Equipment; Equipment and supply inventories; Goals; Investigational Drugs; Maintenance; Mission; National Institute of Child Health and Human Development; Pharmaceutical Chemistry; Pharmaceutical Preparations; Pharmacology; Production; Proteins; Reproductive Health; Research; Role; United States National Institutes of Health; Validation; X-Ray Crystallography; antagonist; assay development; clinical development; computational chemistry; contraceptive target; drug development; high throughput screening; in vivo evaluation; novel; screening; small molecule

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The CSOF fulfills a unique role by bridging the discovery and validation of contraceptive targets to Investigational New Drug (IND) enabling studies and subsequent clinical development and approval of contraceptive drugs. The required research at the CSOF will encompass discovery and optimization of small molecule antagonists and/or agonists of protein targets as anti-fertility agents and related disciplines to support that goal. This includes, but is not limited to, assay development, high throughput screening, x-ray crystallography, computational chemistry, medicinal chemistry, and pharmacology. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.

该任务是开展核心管理活动，包括项目管理、化学和生物清单的存储、归档文件和数据、设备维护以及化学筛选和优化设施（CSOF）中的持续数据库维护活动，以支持NICHD、NIH 避孕研究部门 (CRB) 的避孕药物开发使命。 CSOF 发挥着独特的作用，将避孕靶点的发现和验证与研究性新药 (IND) 联系起来，从而促进避孕药物的研究以及后续的临床开发和批准。 CSOF 所需的研究将包括发现和优化作为抗生育剂的蛋白质靶标的小分子拮抗剂和/或激动剂以及支持该目标的相关学科。这包括但不限于测定开发、高通量筛选、X 射线晶体学、计算化学、药物化学和药理学。该工厂还将负责生产用于初步体内测试的化学材料。预计将进行多个独立项目 同时由 CSOF 负责。对这些项目的适当监督对于其成功执行至关重要。