Data Management and Analysis Core

数据管理与分析核心

• 批准号: 10704189
• 负责人: JENNIFER L. CLARKE
• 金额: $ 28.26万
• 依托单位: UNIVERSITY OF NEBRASKA LINCOLN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10704189
• 关键词: Address; Biochemical; Bioinformatics; Biological; Biological Sciences; Biomedical Research; Biotechnology; Chemicals; Collaborations; Collection; Communication; Communication Research; Communities; Complex; Computational Biology; Computer software; Core Facility; Cryoelectron Microscopy; Data; Data Analyses; Data Management Resources; Data Science; Data Science Core; Data Set; Data Storage and Retrieval; Development; Education; Educational workshop; Equipment; Experimental Designs; FAIR principles; Faculty; Fee-for-Service Plans; Fees; Funding; Generations; Goals; Grant; Human Resources; Image; Individual; Infrastructure; Internet; Laboratories; Libraries; Link; Manuscripts; Molecular Biology; Nebraska; Outcome; Pathway interactions; Peer Review; Phase; Public Health; Publications; Research; Research Personnel; Resources; Role; Services; Statistical Data Interpretation; Technical Expertise; Training; Universities; Workforce Development; base; biomedical data science; cohort; complex data; computational pipelines; computational platform; computer science; cost; cost effective; cyber infrastructure; data exchange; data infrastructure; data management; data pipeline; data portal; data science resource; experimental study; improved; knowledge base; member; molecular imaging; research facility; statistics; structural biology; sustainable resource; tool; web page; web portal; webinar; x-ray free-electron laser

PROJECT SUMMARY/ABSTRACT The broad, long-term goal of the Data and Life Sciences Core (DLSC) within the Nebraska Center for Integrated Biomolecular Communication (CIBC) is to serve as a critical, sustainable resource for biomedical data science and data management expertise, service, and education at the University of Nebraska. The research performed by CIBC investigators will continue to result in the creation of large, complex data sets, particularly for those researchers with projects involving high-throughput biological data and molecular biology data. Proper experimental design, data generation, and subsequent analyses of these data sets requires analytical and computational expertise, access to scientific equipment and relevant technical expertise, high-throughput computing, and resources for data management. Coordinated access to such services is often cost prohibitive and nonintuitive for individual laboratories. Another obstacle faced by many biomedical researchers, including those affiliated with CIBC, is the timely and comprehensive sharing of research data and research findings with collaborators, stakeholders, and the public. To address these issues, CIBC will continue to support DLSC. DLSC provides hardware, software, and expertise in experimental design, bioinformatics, computational biology, statistics, computer science, data management, and advanced cyberinfrastructure to CIBC investigators and the wider university community. To date, DLSC has launched a web portal for data transfer, hosting, and sharing through Globus and the University of Nebraska’s Holland Computing Center; initiated collaborations with CIBC researchers leading to presentations and publications; provided access to analytical software; and hosted training and workforce development opportunities. The immediate goal of DLSC for Phase 2 is to expand and strengthen the core’s data science and data management infrastructure, services, expertise, and educational programming in support of CIBC investigators and the Center’s overall goals and long-term sustainability. This will be achieved through four aims: 1) expand an existing computational platform for data storage, analysis, and management to include support for biomolecular imaging experiments and integration with the Research Space platform, 2) promote core sustainability by initiating collaborations with personnel across the University of Nebraska campuses to enable complex, interdisciplinary biomedical projects that require expertise in data science and data management, 3) serve a critical, sustainable role in CIBC research by collaborating on CIBC projects, both as authors on research publications relevant to CIBC and as investigators on subsequent proposals for internal and external research funding, and 4) educate CIBC members about the role of data science in chemical and biochemical research, the potential and caveats of experimental data, and start-of-the- art resources and pipelines for data preprocessing and analysis. DSLC will continue to capitalize on existing expertise at the University of Nebraska, hire needed expertise, and build long-term core sustainability.

项目概要/摘要 内布拉斯加州综合中心数据和生命科学核心 (DLSC) 的广泛、长期目标 生物分子通讯（CIBC）将成为生物医学数据科学的关键、可持续资源 内布拉斯加大学的数据管理专业知识、服务和教育。 CIBC 调查人员将继续创建大型、复杂的数据集，特别是对于那些 项目涉及高通量生物数据和分子生物学数据的研究人员。 实验设计、数据生成以及这些数据集的后续分析需要分析和 计算专业知识、获得科学设备和相关技术专业知识、高通量 计算和数据管理资源的协调访问通常成本高昂。 对于单个实验室来说，这是许多生物医学研究人员面临的另一个障碍，包括 CIBC 的附属机构，及时、全面地与其他机构分享研究数据和研究成果 为了解决这些问题，CIBC 将继续支持 DLSC。 提供实验设计、生物信息学、计算生物学方面的硬件、软件和专业知识， 为 CIBC 调查人员和调查人员提供统计学、计算机科学、数据管理和先进的网络基础设施 迄今为止，DLSC 已经推出了一个用于数据传输、托管和共享的门户网站。 通过 Globus 和内布拉斯加大学荷兰计算中心与 CIBC 发起合作； 研究人员进行演示和出版物；提供分析软件的访问权限； DLSC 第二阶段的近期目标是扩大和扩大培训和劳动力发展机会。 加强核心的数据科学和数据管理基础设施、服务、专业知识和教育 支持 CIBC 调查人员以及中心的总体目标和长期可持续性的规划。 将通过四个目标来实现：1）扩展现有的数据存储、分析和计算平台 管理包括对生物分子成像实验的支持以及与研究空间的整合 平台，2）通过与整个大学的人员开展合作来促进核心可持续性 内布拉斯加州校园支持需要数据专业知识的复杂、跨学科生物医学项目 科学和数据管理，3) 通过与 CIBC 合作，在 CIBC 研究中发挥关键、可持续的作用 项目，既作为 CIBC 相关研究出版物的作者，又作为后续项目的调查员 内部和外部研究经费提案，以及 4) 向 CIBC 成员介绍数据的作用 化学和生化研究中的科学、实验数据的潜力和注意事项以及开始- DSLC 将继续利用现有的艺术资源和数据预处理和分析渠道。 内布拉斯加大学的专业知识，聘请所需的专业知识，并建立长期的核心可持续性。