Cherenkov imaging incorporating 3D surface imaging for TSET

切伦科夫成像结合 TSET 的 3D 表面成像

• 批准号: 10689148
• 负责人: Timothy C. Zhu
• 金额: $ 49.24万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689148
• 关键词: 3-Dimensional; Agreement; Algorithms; Anatomic Surface; Anatomy; Cancer Patient; Clinical; Clinical Trials; Collaborations; Computer software; Computers; Data; Dependence; Development; Dose; Dose Rate; Electrons; Elements; Engineering; Ensure; Foundations; Geometry; Goals; Human; Hybrids; Image; Imaging technology; Incidence; Light; Linear Accelerator Radiotherapy Systems; Location; Maps; Measurement; Measures; Methods; Monitor; Monte Carlo Method; Movement; Mycosis Fungoides; Optics; Overdose; Patients; Photons; Physiologic pulse; Pilot Projects; Positioning Attribute; Posture; Procedures; Property; Radiation; Radiation Dose Unit; Radiation Monitoring; Radiation therapy; Reporting; Scanning; Schools; Signal Transduction; Site; Skin; Skin Tissue; Software Tools; Solid; Surface; System; Techniques; Technology; Testing; Time; Tissues; Umbilicus; Uncertainty; absorption; animation; body position; cherenkov imaging; detector; dosimetry; improved; in vivo; individual patient; invention; light scattering; optical spectra; prospective; public health relevance; radiation delivery; simulation; software systems; support tools; technology platform; tool; treatment planning; two-dimensional; visual map

Cherenkov imaging incorporating surface imaging for TSET Abstract Whole-body skin electron radiotherapy has been clinically demonstrated to be effective to treat mycosis fungoides. However, due to setup positioning uncertainties and potential patient movements during total skin electron therapy (TSET), dose delivered to the patient skin tissue can deviate from dose prescription. Cherenkov emission from tissue has recently been demonstrated, providing a mapping related to the radiation delivery to skin tissue. The signal is optimally captured by time-gated intensified cameras, synchronized to the linear accelerator pulses, allowing rejection of the majority of background room light, and providing real time video of each radiotherapy treatment with high dose rates. The implementation of Cherenkov imaging offers an excellent technology to detect abnormalities in the treatment, which would otherwise go unnoticed. This proposal seeks to advance this technology as a verification tool through a clinical trial to monitor the daily treatment delivery of TSET patients and develop proper corrections that can be applied to the acquired signal to ensure it is quantitatively accurate in documenting delivered skin dose. Three of the most dominant factors, which alter the linearity between dose and Cherenkov signal, are the corrections for perspective direction, tissue curvature, and tissue optical properties. These important corrections are quantified in this pilot study of TSET, in partnership with DoseOptics LLC, the company that developed the Cherenkov imaging technology for radiation verification, to perfect technology for daily monitoring of radiation delivery. We will compare the dosimetry accuracy of Cherenkov imaging by comparing measurements in-vivo at 9 locations using OSLD and Scintillator detectors. In addition, we will perform measurements in optical phantoms of known tissue optical properties at TSE treatment conditions and Monte-Carlo simulation studies to quantity the three correction factors. We will also develop techniques to overlay skin dose obtained from corrected Cherenkov image to patient-specific surface anatomy based on surface 3D body contour data obtained before TSE treatment to assess the actual skin dose distribution for daily TSE treatment and perform a comprehensive comparison of dose distribution based on MC-based treatment planning system. Taking together, this project will advance on the most compelling systems for radiotherapy imaging in decades. The core of the project is combined technology systems, testing the utility in the setting of TSET.

切伦科夫成像结合 TSET 表面成像 抽象的 全身皮肤电子放射治疗已被临床证明可有效治疗真菌病 蕈样。然而，由于设置定位的不确定性和潜在的患者移动 全皮肤电子治疗 (TSET)，传递到患者皮肤组织的剂量可能会偏离剂量 处方。最近证明了组织的切伦科夫发射，提供了一种映射 与皮肤组织的辐射传递有关。信号通过时间选通增强来最佳捕获 相机，与线性加速器脉冲同步，可以抑制大部分背景 房间灯光，并提供每次高剂量率放射治疗的实时视频。这 切伦科夫成像的实施提供了一种出色的技术来检测异常 治疗，否则会被忽视。该提案旨在推动这项技术成为 通过临床试验的验证工具来监测 TSET 患者的日常治疗情况 制定可应用于采集信号的适当校正，以确保其是定量的 准确记录传递的皮肤剂量。改变现状的三个最主要因素 剂量和切伦科夫信号之间的线性，是透视方向、组织的校正 曲率和组织光学特性。这些重要的修正在这项试点研究中得到了量化 TSET 与 DoseOptics LLC 合作，该公司开发了切伦科夫成像 辐射验证技术，完善辐射输送日常监测技术。我们 将通过比较 9 体内的测量值来比较切伦科夫成像的剂量测定精度 使用 OSLD 和闪烁体探测器的位置。此外，我们还将进行光学测量 TSE 治疗条件和蒙特卡罗模拟下已知组织光学特性的模型 研究量化三个校正因子。我们还将开发叠加皮肤剂量的技术 从校正后的切伦科夫图像获得基于表面 3D 的患者特定表面解剖结构 TSE 治疗前获得的身体轮廓数据，用于评估每日的实际皮肤剂量分布 TSE治疗并基于MC进行剂量分布的综合比较 治疗计划系统。总而言之，该项目将在最引人注目的系统上取得进展 几十年来用于放射治疗成像。该项目的核心是组合技术系统、测试 TSET 设置中的实用程序。

项目成果

Characterization of Cherenkov imaging parameters and positional constraints on an O-ring linear accelerator.

O 形环直线加速器上切伦科夫成像参数和位置约束的表征。

• 发表时间: 2023-10-13
• 影响因子: 3.5
• 作者: Alexander, Daniel A;Majji, Srikanth;Jermyn, Michael;Byrd, Brook K;Bruza, Petr;Li, Taoran;Zhu, Timothy C
• 通讯作者: Zhu, Timothy C