Molecular Virology/Epidemiology HIV Training in Kazakhstan (MoVE-Kaz)

哈萨克斯坦分子病毒学/流行病学艾滋病毒培训 (MoVE-Kaz)

• 批准号: 10689586
• 负责人: Syed Ali
• 金额: $ 30.58万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-10 至 2028-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10689586
• 关键词: Belgium; Central Asia; Collaborations; Communities; Data; Drug resistance; Eastern Europe; Epidemic; Epidemiology; Ethics; Faculty; Funding; Grant; HIV; HIV Infections; Harm Reduction; Health Professional; Individual; Infection; International; Intervention; Kazakhstan; Knowledge; Link; Mentors; Molecular Epidemiology; Molecular Virology; National Institute of Drug Abuse; Patient Care; Persons; Phylogenetic Analysis; Physicians; Population; Public Health; Research; Scientist; Services; Training; Training Programs; Universities; Variant; Viral; cohort; epidemiology study; experience; hands on research; high risk; improved; indexing; programs; skills; tool; transmission process; viral transmission

From 2010 to 2020, the number of new HIV infections in Eastern Europe and Central Asia increased by 43%, while in Kazakhstan, the estimated number of people living with HIV infection (PLWH) increased by 133%, an indication that the key populations transmitting the infections are poorly understood and not effectively linked to harm reduction services, warranting a need for effective training and capacity building for efficient surveillance. Molecular epidemiology approach to reconstruct viral transmission networks forms an explicit part of the Ending the Epidemic program (https://www.cdc.gov/endhiv/index.html). As part of a NIDA-funded grant, we have obtained key information through molecular epidemiology approaches and provided pin-point data regarding high-risk communities in which currently emerging infections suggest their prioritization for intervention. While our NIDA grant has been instrumental in training a handful of young Kazakhstani scientists in cutting-edge molecular epidemiology tools, capacity for such skills is scarce in Kazakhstan. Here, we propose a D43 training program, Molecular Virology Epidemiology in Kazakhstan (MoVE-Kaz), to build capacity for molecular epidemiology research in Kazakhstan. Our specific aims are: 1. To build a pool of well-capacitated Kazakhstani faculty who conduct molecular virology research, we will: a) collaborate with international mentors from Yale University, SUNY-Downstate, and Katholieke Universiteit Leuven in Belgium for the training of two cohorts of 6 Kazakhstani health professionals and young scientists in Molecular Virology (12 trainees total), b) engage local and international mentors to mentor the trainee in applying molecular epidemiology tools for investigating Public Health problems, c) train Kazakhstani health professionals and scientists in the field of molecular virology and epidemiology through short- and long-term training within Kazakhstan, and in New Haven and Leuven. 2. To enhance research capacity for HIV molecular epidemiology in Kazakhstan, our MoVE-Kaz program will train young Kazakhstani physicians and scientists: a) in basic and advanced concepts of molecular virology and epidemiology through two 3-month certificate courses, b) to develop hands-on research skills through an 18-month research certificate course molecular virology for studying transmission and emergence of infection, drug resistance, and viral variants – applying this knowledge to improve HIV surveillance and patient care, c) in ethical conduct of research that meets international standards, and d) in developing competitive grants to fund research in molecular virology and epidemiology. Given the continued surge of HIV in CA, we believe the topic and timing of the training grant is compelling. With our experienced and internationally recognized team of experts in phylogenetic analysis, we believe that we can make a substantial leap in capacity-building for young individual scientists in Kazakhstan.

2010年至2020年，东欧和中亚地区新增艾滋病毒感染人数增加了43%， 而在哈萨克斯坦，艾滋病毒感染者 (PLWH) 的估计人数增加了 133%， 表明人们对传播感染的关键人群知之甚少，并且与感染没有有效联系 减少伤害服务，需要有效的培训和能力建设，以提高效率 重建病毒传播网络的分子流行病学方法形成了一种方法。 结束流行病计划的明确部分（https://www.cdc.gov/endhiv/index.html）。 NIDA资助，我们通过分子流行病学方法获得了关键信息 并提供了有关当前出现感染的高风险社区的精确数据 建议他们优先考虑干预措施，而我们的 NIDA 赠款在培训人员方面发挥了重要作用。 少数哈萨克斯坦年轻科学家拥有尖端分子流行病学工具、 哈萨克斯坦缺乏此类技能，在此，我们提出了 D43 培训计划：分子病毒学。 哈萨克斯坦流行病学 (MoVE-Kaz)，旨在建设哈萨克斯坦分子流行病学研究能力 哈萨克斯坦。我们的具体目标是： 1. 建立一支能力良好的哈萨克斯坦教师队伍。 对于进行分子病毒学研究的人，我们将： a) 与来自以下国家的国际导师合作： 耶鲁大学、纽约州立大学北部分校和比利时鲁汶天主教大学共同培训 两组 6 名哈萨克斯坦卫生专业人员和分子病毒学领域的年轻科学家（12 受训者总数），b）聘请本地和国际导师指导受训者应用分子 用于调查公共卫生问题的流行病学工具，c）培训哈萨克斯坦卫生专业人员 以及分子病毒学和流行病学领域的科学家通过短期和长期培训 哈萨克斯坦境内以及纽黑文和鲁汶 2. 加强艾滋病毒研究能力。 哈萨克斯坦的分子流行病学，我们的 MoVE-Kaz 项目将培训哈萨克斯坦年轻人 医生和科学家：a) 分子病毒学和流行病学的基本和高级概念 通过两门为期 3 个月的证书课程，b) 通过为期 18 个月的培训培养实践研究技能 研究证书课程分子病毒学，用于研究感染的传播和出现， 耐药性和病毒变异——应用这些知识来改善艾滋病毒监测和患者 关怀，c) 符合国际标准的研究道德行为，以及 d) 开发 鉴于持续的情况，竞争性拨款资助分子病毒学和流行病学研究。 加利福尼亚州艾滋病毒激增，我们相信培训补助金的主题和时机非常引人注目。 经验丰富且国际公认的系统发育分析专家团队，我们相信 我们可以在哈萨克斯坦年轻科学家的能力建设方面取得重大飞跃。