Quantitation and Spatial Registration of Airways Dysfunction with Dynamic 19F MRI in Cystic Fibrosis

囊性纤维化中动态 19F MRI 气道功能障碍的定量和空间配准

基本信息

批准号：
10688254
负责人：
Jennifer L Goralski
金额：
$ 20.1万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2025-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688254
关键词：
17 year old Acute Address Adolescent Adopted Adult Adverse effects Age Air Airway Disease Alveolar Anesthetics Asthma Biochemical Biological Biological Markers Biometry Biostatistical Methods Blood Blood capillaries Breathing Bronchiectasis Child Childhood Chronic Chronic Obstructive Pulmonary Disease Clinical Clinical Investigator Clinical Research Clinical Trials Contrast Media Cross-Sectional Studies Cystic Fibrosis Data Development Disease Early Diagnosis Ensure Feasibility Studies Fluorine Functional disorder Gases Goals Grant High Resolution Computed Tomography Image Infant Inhalation Ionizing radiation Life Longitudinal Studies Lung Lung Transplantation Lung diseases Magnetic Resonance Imaging Measurement Measures Medical Medical Imaging Methods Mucous body substance Nitrogen Outcome Outcome Measure Oxygen Patients Performance Pharmaceutical Preparations Physiological Population Protons Pulmonary Cystic Fibrosis Pulmonary Function Test/Forced Expiratory Volume 1 Pulmonary function tests Quality of life Questionnaires Radiation exposure Reporting Research Research Design Research Personnel Respiratory Failure Respiratory Tract Infections Risk Sedation procedure Site Solubility Spirometry Structure Symptoms Techniques Technology Testing Time Training Vulnerable Populations absorption advanced disease airway inflammation chest computed tomography children with cystic fibrosis clinical outcome measures cohort cost cystic fibrosis patients effectiveness evaluation healthy volunteer indexing informal learning innovation lung imaging novel therapeutics pediatric patients preservation prevent public health relevance pulmonary function training opportunity treatment response triplet state ventilation

项目摘要

ABSTRACT Quantitation and Spatial Registration of Airways Dysfunction with Dynamic 19F MRI in Cystic Fibrosis Rationale: Currently available endpoints for testing of new therapies in CF typically are either insensitive to focal changes in lung disease and early lung disease (e.g. spirometry), or require ionizing radiation (e.g. chest CT). These problems limit their utility, and typically prevent repetitive use, particularly in young children. The addition of an inhaled gas as a contrast agent to quantify ventilation while preserving spatial inforrmation using MRI techniques is an important advance in pulmonary imaging, but is not yet widely available. We propose to develop the use of a perfluorinated gas for MRI imaging, which may have several important advantages over other techniques, including being readily transferrable to other research centers. Methods: Subjects with cystic fibrosis will undergo perfluoropropane (PFP)-enhanced magnetic resonance imaging (19F MRI), in addition to 1H ultrashort echo time (UTE) MRI. In a longitudinal study, we will evaluate the short-term variability and responsiveness of 19F MRI to disease state changes while exploring the relationship between functional changes in ventilation and lung structure. Parallel measurement of traditional outcome measures (spirometry, lung clearance index, and patient symptoms) will help evaluate whether additional sensitivity and value is added by this technique. Subjects will be tested in relation to pulmonary exacerbations as well to determine measure performance over different physiologic states. 19F MRI will be extended down to the pediatric age range to determine the feasibility of performing these studies in young children, and the ability to detect disease in children with normal spirometry. Training: Dr. Goralski will embark upon specialized training in clinical research topics (advanced study design and biostatistics), as well as training in medical imaging analysis to further her goal in becoming an independent investigator. She will also seek both formal and informal education in advance study design and biostatistical methods. Expected Results: We expect that 19F MRI will readily detect abnormalities in small airway function in subjects with CF lung disease, that measurements will be valid over short time frames, and that they will reflect acute changes in disease activity (i.e. exacerbations). We further expect that 19F MRI will be feasible in young children and will be able to detect ventilation inhomogeneity, even in young CF subjects with normal lung function tested by conventional means (i.e. spirometry).

抽象的囊性纤维化中动态 19F MRI 气道功能障碍的定量和空间配准理由：目前用于测试 CF 新疗法的可用终点通常对局灶性不敏感肺部疾病和早期肺部疾病的变化（例如肺活量测定），或需要电离辐射（例如胸部 CT）。这些问题限制了它们的实用性，并且通常会妨碍重复使用，特别是对于幼儿。补充使用吸入气体作为造影剂来量化通气量，同时使用 MRI 保留空间信息技术是肺部成像的重要进步，但尚未广泛应用。我们建议开发使用全氟化气体进行 MRI 成像，与其他气体相比，它可能具有几个重要优势技术，包括易于转移到其他研究中心。方法：患有囊性纤维化的受试者除了 1H 之外，还将接受全氟丙烷 (PFP) 增强磁共振成像 (19F MRI) 超短回波时间 (UTE) MRI。在纵向研究中，我们将评估短期变异性和 19F MRI 对疾病状态变化的反应，同时探索功能变化之间的关系通气和肺结构。传统结果测量（肺活量测定、肺功能测定）的并行测量清除指数和患者症状）将有助于评估是否增加了额外的敏感性和价值这项技术。还将对受试者进行与肺部恶化相关的测试以确定措施不同生理状态下的表现。 19F MRI 将扩展到儿科年龄范围确定在幼儿中进行这些研究的可行性以及检测儿童疾病的能力与正常肺活量测定法。培训：Goralski 博士将开始接受临床研究主题的专门培训（高级研究设计和生物统计学），以及医学成像分析培训，以进一步实现她的目标成为一名独立调查员。她还将在预科学习中寻求正规和非正规教育设计和生物统计学方法。预期结果：我们期望 19F MRI 能够轻松检测到异常情况患有 CF 肺病的受试者的小气道功能，测量在短时间内有效，它们将反映疾病活动的急剧变化（即恶化）。我们进一步期望 19F MRI 对于幼儿来说是可行的，并且能够检测通气不均匀性，甚至在年轻的 CF 受试者中也是如此通过常规方法（即肺量测定法）测试肺功能正常。