Admin: Mechanical determinants of organ-selective metastatic colonization, dormancy and outgrowth

管理员：器官选择性转移定植、休眠和生长的机械决定因素

基本信息

批准号：
10688245
负责人：
ROGER D KAMM
金额：
$ 18.93万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-17 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10688245
关键词：
Achievement Address Administrator Advisory Committees Advocate Agreement Applications Grants Award Biochemical Breast Cancer Patient Cells Cessation of life Chromatin Chromatin Structure Circulation Clinical Data Collaborations Communication Communities Computer Models Dana-Farber Cancer Institute Data Data Commons Data Set Development Disease Disease Progression Disseminated Malignant Neoplasm Ensure Environment Evaluation Exposure to Fostering Gene Expression Profile Grant In Vitro Institution Intervention Knowledge Lead Leadership Malignant Neoplasms Mechanics Mission Modeling Molecular Monitor Neoplasm Circulating Cells Neoplasm Metastasis Organ Pathology Patients Pennsylvania Phenotype Pilot Projects Program Reviews Proliferating Protocols documentation Publications Quality Control Records Reporting Reproducibility Research Research Personnel Research Project Grants Resource Sharing Schedule Scientist Series Signal Transduction Site Visit Source Stress Stromal Cells Structure Technology Texas Tissues Universities Validation Videoconferencing Visit anticancer research data quality data sharing high resolution imaging in silico in vivo meetings member metadata standards multidisciplinary neoplastic cell programs repository research data dissemination response skill acquisition stressor symposium timeline transcriptome transcriptomics tumor microenvironment virtual web site webinar working group

项目摘要

Administrative Core: SUMMARY We propose to bring together an unparalleled team comprised of five leaders in metastatic cancer research across five institutions (MIT, University of Pennsylvania, Northwestern University, MD Anderson at The University of Texas, and the Dana Farber Cancer Institute at Harvard University). The proposed MetNet Center Administrative Core will be led by co-MPI Prof. Roger Kamm. The day-to-day administration of this grant will be managed by the Center Administrator, located at MIT, who will be responsible for maintaining all records relative to this award and will establish and monitor agreements with affiliated institutions. Additionally, center administration will be supported by a Data Manager, who will be located at Harvard under the co-direction of Dr. Franziska Michor. The Data Manager will sit on the Resource and Data Sharing Working Group of MetNet and will be responsible for the co-development (in collaboration with the Center Administrator) of the MetNet Center’s website, discussions regarding standard metadata fields, determine whether there will be pre-publication of data sharing across the MetNet, create SOPs for MetNet data upload in conjunction with the different NCI Cancer Research Data Commons, and lead the conversations about data quality control, cross validation, and reproducibility. An External Advisory Committee (EAC) will be formed, bringing together investigators with expertise in fields related to cancer metastasis and the tumor microenvironment. The EAC is envisioned as a group of highly active members engaged to advise the MetNet Center leadership on scientific direction and review progress evaluation, research strategies and implementation, leadership and dissemination, all in the effort to maximize the impact of the center. The MetNet center will enhance the translational value and potential impact of its research by engaging a Patient Advocate, who will be a member of the EAC as a reviewer and evaluator of the pilot project grant applications, and will be invited to attend the monthly research webinars and participate in the quarterly Co-MPI meetings, and the Annual Site Visit. To foster collaboration and further support multi-institutional communication, wide reaching knowledge dissemination, and provide the MetNet Center trainees opportunities for enhancing their technical and professional development skills, the Administrative Core will support a virtual, monthly seminar series, and will offer intra-MetNet Center research exchanges and $50,000 pilot projects. In Aim 1 the Administrative Core will oversee and coordinate the project mission, establish multidisciplinary project oversight and establish timeline milestones with videoconferencing and face-to-face meetings. In Aim 2, we will develop, coordinate, schedule, and evaluate research meetings, research symposia, and the visiting scientists’ programs that are critical to our research mission and dissemination. In Aim 3, we will create the MetNet Center’s website to: facilitate communication on program achievements; act as the access point for enquiries from external researchers; serve as publicly-facing source of accessible research results to inform the breast cancer patient community; and serve as a central and accessible repository for all Center generated protocols.

行政核心：摘要我们建议组建一个由五位转移性癌症领域的领导者组成的无与伦比的团队跨五个机构（麻省理工学院、宾夕法尼亚大学、西北大学、MD 安德森大学）的研究德克萨斯大学和哈佛大学 Dana Farber 癌症研究所）。行政核心将由 MPI 联合教授 Roger Kamm 领导，该补助金的日常管理将由其负责。由位于麻省理工学院的中心管理员管理，他将负责维护所有相关记录并将与附属机构建立并监督协议。行政管理将由一名数据经理提供支持，该经理将驻扎在哈佛大学，并在哈佛博士的共同指导下。 Franziska Michor 是 MetNet 的资源和数据共享工作组的数据经理。将负责（与中心管理员合作）MetNet 中心的共同开发网站，讨论标准元数据字段，确定是否预发布数据在 MetNet 上共享，与不同的 NCI 癌症联合创建 MetNet 数据上传的 SOP 研究数据共享，并领导有关数据质量控制、交叉验证和将成立一个外部咨询委员会（EAC），将研究人员聚集在一起。 EAC 被设想为癌症转移和肿瘤微环境相关领域的专业知识。一群高度活跃的成员致力于为 MetNet 中心领导层提供有关科学方向和审查进展评估、研究策略和实施、领导和传播，所有这些都在努力最大限度地发挥该中心的影响力 MetNet 中心将增强转化价值和潜力。通过聘请患者倡导者来影响其研究的影响，患者倡导者将成为 EAC 的成员，担任审查员，试点项目拨款申请的评估员，并将受邀参加每月的研究网络研讨会和参加季度 Co-MPI 会议和年度现场访问，以促进合作和进一步支持。多机构沟通、广泛的知识传播以及提供 MetNet 中心学员有机会提高其技术和专业发展技能，行政核心将支持每月一次的虚拟研讨会系列，并将提供 MetNet 中心内部研究交流和 50,000 美元在目标 1 中，行政核心将监督和协调项目任务，建立试点项目。通过视频会议和面对面的方式进行多学科项目监督并建立时间表里程碑在目标 2 中，我们将制定、协调、安排和评估研究会议、研究研讨会、以及对我们的研究任务和传播至关重要的访问科学家计划。创建 MetNet 中心的网站，以：促进项目成果的交流；外部研究人员的询问点；作为可获取研究结果的公开来源；向乳腺癌患者社区提供信息；并作为所有中心的中央且可访问的存储库；生成的协议。