Use of Novel Multi-modality Imaging to Evaluate the Relationship Between Sleep Duration, Vascular Inflammation, and Visceral Adiposity

使用新型多模态成像评估睡眠持续时间、血管炎症和内脏肥胖之间的关系

• 批准号: 10687854
• 负责人: Vaishnavi Kundel
• 金额: $ 19.11万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10687854
• 关键词: Abdomen; Academy; Adipose tissue; Adult; Age; American; American Heart Association; Atherosclerosis; Award; Biological Markers; Blood; Blood Vessels; Body mass index; Cardiometabolic Disease; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Chest; Chronic; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Development; Development Plans; Diagnosis; Doctor of Philosophy; Environment; Epidemic; Event; Exclusion; Faculty; Foundations; Funding; Future; Goals; Grant; Health; Home; Hour; Hybrids; Image; Inflammation; Inflammatory; Interdisciplinary Study; Internal Medicine; Investigation; K-Series Research Career Programs; Link; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Medicine; Mentors; Metabolic; Multi-Ethnic Study of Atherosclerosis; Multimodal Imaging; Myocardial Infarction; Neck; Obesity; Observational Study; Obstructive Sleep Apnea; Outcome; PET/CT scan; Pathway interactions; Patient Recruitments; Patient Self-Report; Patients; Pilot Projects; Population; Positron-Emission Tomography; Prevention strategy; Race; Recommendation; Reproducibility; Research; Research Design; Research Personnel; Residual state; Risk Factors; Role; Science; Sleep; Sleep Deprivation; Sleep disturbances; Solid; Specimen; Standardization; Stroke; Systems Biology; Testing; Therapeutic Intervention; Thoracic aorta; Time; Training; Visceral; actigraphy; biobank; biomarker identification; body system; cardiometabolic risk; cardiometabolism; cardiovascular disorder risk; cardiovascular imaging; cardiovascular risk factor; career; career development; cohort; design; disorder risk; early detection biomarkers; epidemiology study; experience; fluorodeoxyglucose positron emission tomography; imaging biomarker; indexing; inflammatory marker; insight; medical schools; modifiable risk; multidisciplinary; multimodality; novel; novel marker; patient oriented research; patient subsets; prognostic indicator; recruit; sex; sleep onset; sleep pattern; sleep physiology; success; systemic inflammatory response; targeted treatment; trend; uptake; vascular inflammation

ABSTRACT The proposed training grant is designed to advance the academic career of Dr. Vaishnavi Kundel, MD, by building upon her strong background in clinical sleep medicine to engage in patient-oriented research, and develop expertise in exploring the role of sleep in cardiometabolic disease risk. Through this proposal, she will obtain multidisciplinary training to investigate chronic sleep deprivation and sleep irregularity as potentially modifiable risk factors for atherosclerosis and visceral adiposity measured using multi-modality imaging - hybrid 18fluorodeoxyglucose (FDG) PET/MRI. Research plan: The proposed research builds on Dr. Kundel's pilot studies funded by the AASM. The aims are to determine whether habitual short sleep duration and sleep irregularity are associated with increased vascular inflammation and visceral adiposity (which is strongly linked to increased CVD risk), independent of OSA (often a confounder in these associations). We will utilize multi-day actigraphy to collect objective sleep metrics, and PET/MRI to measure vascular inflammation and visceral adipose tissue (VAT) metabolic activity (a novel marker of adipose tissue inflammation) in the recruited patients. With successful completion of the proposed training and research, we hope to underscore the role of chronic sleep deprivation and sleep irregularity in cardiometabolic risk, establishing an index of imaging biomarkers for future research. Moreover, the results will provide direction for future (R01) proposals - laying the groundwork for developing multidisciplinary collaborations to elucidate mechanisms by which sleep modulates inflammation, with a long-term goal of identifying biomarkers of early cardiovascular risk in this subset of patients, and designing sleep extension studies. Career Development: Dr. Kundel's training plan features an outstanding research environment at the Icahn School of Medicine at Mount Sinai along with nationally renowned mentors and advisors with complimentary expertise. Her primary mentoring team comprises of (a) Dr. Neomi Shah, MD, MPH, MS (expert in obstructive sleep apnea [OSA] and cardiovascular (CV) diseases, and application of advanced cardiovascular imaging in OSA) (b) Dr. Indu Ayappa, PhD, (recipient of a mentored K-24 award, with expertise in OSA, sleep physiology, and use of actigraphy for objective sleep assessments) (c) Drs. Zahi Fayad and Philip Robson, PhD (experts in use of multimodality imaging for assessment of atherosclerosis and organ system biology). Her training features a combination of carefully designed coursework and practical experiences in 1) actigraphy for comprehensive assessments of objective sleep metrics 2) multi-modality cardiometabolic imaging 3) clinical study design and patient-oriented research 4) training in biomarker science for future proposals. Together, her mentors and advisors have a successful track record of mentoring junior faculty in career development awards, with extensive collaborations and grant portfolios to provide a solid foundation for Dr. Kundel's present proposal, and ultimate success in developing into an independent investigator.

抽象的 拟议的培训补助金旨在促进医学博士 Vaishnavi Kundel 博士的学术生涯 凭借她在临床睡眠医学方面的深厚背景，从事以患者为中心的研究，以及 培养探索睡眠在心脏代谢疾病风险中的作用的专业知识。通过这个提议，她将 获得多学科培训，以调查潜在的慢性睡眠不足和睡眠不规律 使用多模态成像-混合测量动脉粥样硬化和内脏肥胖的可改变危险因素 18 氟脱氧葡萄糖 (FDG) PET/MRI。研究计划：拟议的研究以昆德尔博士的试点为基础 由 AASM 资助的研究。目的是确定习惯性短睡眠持续时间和睡眠是否正常。 不规则性与血管炎症和内脏肥胖的增加有关（这与 CVD 风险增加），独立于 OSA（通常是这些协会中的混杂因素）。我们将利用多日 体动记录仪收集客观睡眠指标，PET/MRI 测量血管炎症和内脏炎症 招募患者的脂肪组织（VAT）代谢活动（脂肪组织炎症的新标志物）。 随着拟议的培训和研究的成功完成，我们希望强调慢性病的作用 睡眠不足和睡眠不规律对心脏代谢风险的影响，建立了一个影像生物标志物指数 未来的研究。此外，结果将为未来（R01）提案提供方向——奠定基础 发展多学科合作以阐明睡眠调节炎症的机制， 长期目标是识别这部分患者的早期心血管风险生物标志物，以及 设计睡眠延长研究。职业发展：昆德尔博士的培训计划具有突出的特点 西奈山伊坎医学院的研究环境以及全国知名的导师 以及具有互补专业知识的顾问。她的主要指导团队包括 (a) Neomi Shah 博士（医学博士）、 MPH、MS（阻塞性睡眠呼吸暂停 [OSA] 和心血管 (CV) 疾病及其应用专家 OSA 中的先进心血管成像） (b) Indu Ayappa 博士（K-24 指导奖获得者， OSA、睡眠生理学和使用体动记录仪进行客观睡眠评估方面的专业知识） (c) Drs.扎希·法耶德 和 Philip Robson 博士（使用多模态成像评估动脉粥样硬化和器官的专家） 系统生物学）。她的培训结合了精心设计的课程和实践经验 1) 用于客观睡眠指标综合评估的体动记录仪 2) 多模态心脏代谢 成像 3) 临床研究设计和以患者为导向的研究 4) 未来生物标志物科学培训 提案。她的导师和顾问在指导初级教师方面有着成功的记录。 职业发展奖项，通过广泛的合作和赠款组合，为 昆德尔博士目前的建议，以及最终成功发展成为一名独立研究者。

项目成果

Reimagining obstructive sleep apnoea: a new era for sleep medicine.

重新想象阻塞性睡眠呼吸暂停：睡眠医学的新时代。

• 发表时间: 2023-11
• 作者: Kundel, Vaishnavi;Cohen, Oren;Shah, Neomi
• 通讯作者: Shah, Neomi

Permanent standard time is the optimal choice for health and safety: an American Academy of Sleep Medicine position statement.

永久标准时间是健康和安全的最佳选择：美国睡眠医学会立场声明。

• 发表时间: 2024-01-01
• 作者: Rishi, Muhammad Adeel;Cheng, Jocelyn Y;Strang, Abigail R;Sexton;Ganguly, Gautam;Licis, Amy;Flynn;Berneking, Michael W;Bhui, Raj;Creamer, Jennifer;Kundel, Vaishnavi;Namen, Andrew M;Spector, Andrew R;Olaoye, Olatunji
• 通讯作者: Olaoye, Olatunji

Heterogeneous Effects of CPAP in Non-Sleepy OSA on CVD Outcomes: Post-hoc Machine Learning Analysis of the ISAACC Trial (ECSACT Study).

非瞌睡 OSA 中 CPAP 对 CVD 结果的异质影响：ISAACC 试验的事后机器学习分析（ECSACT 研究）。

• 发表时间: 2024-02-15
• 影响因子: 8.3
• 作者: Cohen, Oren;Sánchez;Al;Khan, Samira;Kundel, Vaishnavi;Kovacic, Jason C;Gracia;de Batlle, Jordi;Nadkarni, Girish;Barbé, Ferran;Suárez;Shah, Neomi A
• 通讯作者: Shah, Neomi A