Deciphering the function of Mce proteins from Mycobacterium tuberculosis

解读结核分枝杆菌 Mce 蛋白的功能

• 批准号: 8122328
• 负责人: Fabiana Bigi
• 金额: $ 8.7万
• 依托单位: NATIONAL INSTITUTE OF AGRICULTURE TECH
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8122328
• 关键词: ATP-binding cassette transport; Actinomycetales; Bacteria; Biological Process; Carbon; Cells; Cholesterol; Collection; Complex; Data; Development; Faculty; Gene Expression; Genes; Genome; Genus Mycobacterium; Goals; Health; Host Defense; Human; Infection; Invaded; Investigation; Knowledge; Lipids; Membrane; Metabolism; Modeling; Mycobacterium smegmatis; Mycobacterium tuberculosis; Open Reading Frames; Operon; Organism; Physiological; Process; Protein Family; Proteins; RNA; Regulator Genes; Research; Role; Structural Genes; System; Technology; Training; Transmembrane Transport; Tuberculosis; Vaccines; Virulence; Virulence Factors; Work; base; design; disorder control; experience; insight; lipid metabolism; lipid transport; mouse model; mutant; mycobacterial; pathogenic bacteria; success; working group

DESCRIPTION (provided by applicant): Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine. PUBLIC HEALTH RELEVANCE: Tuberculosis (TB) continues to be a major health problem worldwide. Mycobacterium tuberculosis, the agent of human TB, uses proteins and other compounds called "virulence factors" to subvert human host defenses and damage and invade human host cells during infection. The main goal of this project is to study a family of proteins necessary for M. tuberculosis success in host infection. Therefore, this study could bring insight in the knowledge of the mechanisms involved in the infective process of M. tuberculosis in humans. A better understanding of this process will contribute to the development of new strategies to control this disease including the design of an effective vaccine.

描述（由申请人提供）：结核病（TB）在全球范围内仍然是一个主要的健康问题。结核分枝杆菌是人类结核病的药物，使用蛋白质和其他称为“毒力因子”的化合物来颠覆人类的宿主防御和损害，并在感染过程中侵入人类宿主细胞。该项目的主要目的是研究宿主感染中结核分枝杆菌成功所需的蛋白质家族。因此，这项研究可能会深入了解人类结核分枝杆菌的感染过程的知识。更好地了解这一过程将有助于制定控制这种疾病的新策略，包括设计有效的疫苗。公共卫生相关性：结核病（TB）在全球范围内仍然是一个主要的健康问题。结核分枝杆菌是人类结核病的药物，使用蛋白质和其他称为“毒力因子”的化合物来颠覆人类的宿主防御和损害，并在感染过程中侵入人类宿主细胞。该项目的主要目的是研究宿主感染中结核分枝杆菌成功所需的蛋白质家族。因此，这项研究可能会深入了解人类结核分枝杆菌的感染过程的知识。更好地了解这一过程将有助于制定控制这种疾病的新策略，包括设计有效的疫苗。