Integrated Research Facility at Fort Detrick

德特里克堡综合研究设施

基本信息

批准号：
7970183
负责人：
Peter Jahrling
金额：
$ 3426.93万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7970183
关键词：
Animal Model Biological Cell Surface Receptors Cells Centers for Disease Control and Prevention (U.S.)Clinical Clinical Research Communicable Diseases Containment Cowpox virus Development Disease Emerging Communicable Diseases Filovirus Glycoproteins Infection Infectious Diseases Research Intramural Research Intravenous Laboratories Maryland Medical Medical Imaging Medical Research Methods Mission Mitoxantrone Modeling Monkey Hemorrhagic Disease Virus Monkeypox virus National Institute of Allergy and Infectious Disease Orthopoxvirus Outcome Pathogenesis Patients Public Health Research Research Institute Research Project Grants Role Route Science Tracer United States United States National Institutes of Health Vaccines Viral Viral Pathogenesis Virus Virus Diseases biodefense improved in vivo nonhuman primate novel pathogen programs research facility tool

项目摘要

For FY09, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research. Project 1: Viral pathogenesis of orthopoxviruses and development of countermeasures against infection: Introduction and Objectives 1) Characterize monkeypox virus infection of nonhuman primates by the intravenous and intrabronchial route. 2) Determine if cowpox virus infection of nonhuman primates could serve as a BSL-2 model of orthopoxvirus infection. 3) Determine the efficacy of mitoxantrone against cowpox virus in vivo. Project 2: Viral pathogenesis of simian hemorrhagic fever virus: Introduction and Objectives 1) To characterize the pathogenesis of simian hemorrhagic fever virus in nonhuman primates. Project 3: Identification of cell-surface receptors of viral entry: 1) Identification of cell-surface receptors for NIAID Priority Pathogens. 2) Identification of the cell-surface receptor of simian hemorrhagic fever virus. 3) Characterization of the role of filoviral secreted glycoproteins in filovirus cell entry. Project 4: Develop methods for medical imaging of infectious disease: 1) Development of tracers for orthopox viruses and filoviruses.

对于09财年，临床研究部门的综合研究机构显着提高了其提供的研究促进水平。首先，该支持已指示促进新兴病毒病原体部分在壁内研究部门的生物化和新兴的传染病研究。项目1：正托病毒的病毒发病机理和针对感染的对策的发展：介绍和目标 1）表征非人类灵长类动物的蒙基氧基病毒通过静脉内和临时途径。 2）确定非人类灵长类动物的牛波克病毒感染是否可以用作正托病毒感染的BSL-2模型。 3）确定Mitoxantrone在体内对牛肝病毒的疗效。项目2：猿猴出血性发烧病毒的病毒发病机理：介绍和目标 1）表征非人类灵长类动物中猿猴出血热病毒的发病机理。项目3：病毒进入的细胞表面受体的识别： 1）鉴定NIAID优先病原体的细胞表面受体。 2）鉴定猿猴出血热病毒的细胞表面受体。 3）表征丝状病毒糖蛋白在丝状病毒细胞进入中的作用。项目4：开发传染病医学成像的方法： 1）开发正毒病毒和丝状病毒的示踪剂。