METABOLIC ACTIVATION OF AIR TOXICS IN ASTHMATIC MONKEYS

哮喘猴体内空气毒物的代谢激活

• 批准号: 7959009
• 负责人: Alan R Buckpitt
• 金额: $ 3.56万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959009
• 关键词: Adolescent; Air; Air Pollutants; Asthma; California; Computer Retrieval of Information on Scientific Projects Database; Epidemiologic Studies; Exposure to; Extrinsic asthma; Funding; Grant; House Dust Mite Allergens; Incidence; Institution; Lung; Macaca mulatta; Metabolic Activation; Modeling; Monkeys; Ozone; Particulate; Primates; Research; Research Personnel; Resources; Respiratory physiology; Severities; Site; Source; Structure; Syndrome; Testing; United States National Institutes of Health; Work; Xenobiotic Metabolism; Xenobiotics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Numerous epidemiologic studies have noted associations between exposures to ambient air pollutants (VOC, particulates, ozone) and asthma incidence and severity. Recent work in juvenile rhesus macaques has shown that a syndrome having many of the hallmark signs of allergic asthma can be induced by intermittent ozone and house dust mite allergen (HDMA) exposures. Several of the structural alterations observed in this model occur in the airways, a primary site for pulmonary xenobiotic metabolism. These studies were conducted to test the hypothesis that exposures resulting in fundamental alterations in the structure and function of the lung also alter the ability to metabolize xenobiotics, with a focus on bioactivated xenobiotics.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 大量流行病学研究已注意到暴露于环境空气污染物（挥发性有机化合物、颗粒物、臭氧）与哮喘发病率和严重程度之间的关联。最近对幼年恒河猴的研究表明，间歇性接触臭氧和屋尘螨过敏原 (HDMA) 可能会诱发具有许多过敏性哮喘标志性症状的综合征。在该模型中观察到的一些结构改变发生在气道中，气道是肺部异生物质代谢的主要部位。这些研究的目的是检验这样的假设：暴露导致肺部结构和功能发生根本改变，也会改变异生物质的代谢能力，重点是生物活性的异生物质。