BARTONELLA MODEL FOR AN AIDS OPPORTUNISTIC PATHOGEN

艾滋病机会性病原体的巴尔通体模型

• 批准号: 7959000
• 负责人: JANE E KOEHLER
• 金额: $ 14.66万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959000
• 关键词: Acquired Immunodeficiency Syndrome; Animals; Bacteremia; Bartonella; Bartonella Infections; Biological Models; California; Clinical; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Immune response; Immunocompromised Host; Immunologic Deficiency Syndromes; Institution; Macaca; Modeling; Monitor; Organism; Outcome; Pathogenesis; Primates; Research; Research Personnel; Resources; Source; Staging; System; United States National Institutes of Health; pathogen

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this study is to utilize the SIV/macaque model system to determine the pathogenesis of Bartonella infection in SIV-infected, immunocompromised macaques, and evaluate the SIV/macaque system as a potential model for BA. SIV-infected animals, at various stages of immunodeficiency, will be inoculated intradermally with B. henselae, B. bacilliformis, or B. quintana organisms, and monitored for onset, duration, immune response, and clinical outcome of bacteremia.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目的是利用SIV/猕猴模型系统来确定SIV感染，免疫功能低下猕猴中Bartonella感染的发病机理，并评估SIV/猕猴作为BA的潜在模型。在免疫缺陷的各个阶段，SIV感染的动物将与Henselae，芽孢杆菌芽孢杆菌或Quintana生物芽孢杆菌内接种，并监测发作，持续时间，免疫反应和细菌的临床结果。