Core 2: Pathology Core

核心 2：病理学核心

• 批准号: 10685414
• 负责人: Gabriel Larkin Sica
• 金额: $ 20.88万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-10 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10685414
• 关键词: American Joint Committee on Cancer; Animals; Antibodies; Archives; Biological Markers; Biology; Biometry; Blood; Cancer Patient; Catalogs; Cells; Classification; Clinical Data; Clinical Trials; Collaborations; Collection; Communication; Confidentiality of Patient Information; Consent; Data; Development; Diagnostic; Ensure; Equipment; Flow Cytometry; Formalin; Freezing; Fresh Tissue; Funding; Histocytochemistry; Histopathology; Immunohistochemistry; Infrastructure; Institution; Investigation; Laboratories; Link; Lung; Lung Neoplasms; Malignant Neoplasms; Malignant neoplasm of lung; Molecular Genetics; Nursing Research; Paraffin Embedding; Pathologic; Pathologist; Pathology; Patients; Peer Review; Procedures; Process; Pulmonary Pathology; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Sampling; Scientist; Services; Specimen; Specimen Handling; Staging; Stains; Standardization; Technical Expertise; Tissue Banks; Tissue Embedding; Tissue Microarray; Tissue Sample; Tissue Viability; Tissues; Translational Research; United States National Institutes of Health; Universities; Validation; biobank; biomedical informatics; career; clinically relevant; design; design and construction; experience; human tissue; novel strategies; patient derived xenograft model; programs; prospective; repository; translational study; treatment strategy

SUMMARY/ABSTRACT The objective of the Pathology Core (Core 2) is to serve as a centralized infrastructure to provide the materials and technical expertise necessary to accomplish the translational studies proposed by the Emory University Lung Cancer SPORE Research Projects and Developmental Research and Career Enhancement programs. With experience and expertise specifically in lung cancer pathology, the Core will interact directly with each SPORE project, the Administrative and Biostatistics and Biomedical Informatics Cores, to ensure efficient and highly-coordinated procurement, archiving, and storage of both fresh and archived lung cancer tissue specimens. Continuous communication between clinicians, scientists, research nurses, biostatisticians and pathologists, together with established standardized operating procedures for all core activities, will provide optimal tissue collection and accurate processing, analysis and storage of each sample. The Core will function as the main repository of patient specimens. This Core will utilize and expand the well-established tissue banking efforts at the Winship Cancer Institute of Emory University for translational research, including annotating human tissue samples with relevant clinical and pathologic data that is collected and stored from the patient history, and maintaining patient confidentiality. Histopathologic analysis by the core pathologist will confirm the quality of study tissue in research specimens. Selected cellular biomarkers utilizing immunohistochemistry (IHC) will be interpreted by the core pathologist. In addition, animal study specimen processing, histopathology, IHC, and pathologic interpretive support will be provided. Collectively, the primary functions of the Core are stated in the following aims: 1) Comprehensively acquire, process, store, catalog and disburse tissues, cells and blood with relevant clinico-pathologic data; 2) Provide pathologic and molecular genetic classification of lung tumors and interpretation of immunohistochemical stain results; 3) Facilitate human tissue-based investigation of the SPORE research projects; 4) Support Administrative Core-initiated intra-SPORE collaborations, inter-SPORE collaborations, and collaboration between investigators at our own and other institutions including other peer- reviewed projects funded by NCI/NIH and other agencies using SPORE-generated tissues.

摘要/摘要 病理学核心（核心 2）的目标是作为提供材料的集中式基础设施 以及完成埃默里大学提出的转化研究所需的技术专业知识 肺癌孢子研究项目以及发展研究和职业提升计划。 凭借在肺癌病理学方面的经验和专业知识，核心将直接与每个人互动 SPORE 项目，行政和生物统计以及生物医学信息学核心，以确保高效和 高度协调新鲜和存档肺癌组织标本的采购、存档和储存。 临床医生、科学家、研究护士、生物统计学家和病理学家之间的持续沟通， 与所有核心活动的既定标准化操作程序一起，将提供最佳的组织 每个样品的采集并准确处理、分析和储存。核心将作为主要功能 患者标本储存库。该核心将利用并扩展成熟的组织库工作 埃默里大学温希普癌症研究所进行转化研究，包括注释人体组织 从患者病史中收集和存储的具有相关临床和病理数据的样本，以及 维护患者的机密。核心病理学家的组织病理学分析将确认 研究研究标本中的组织。利用免疫组织化学 (IHC) 选定的细胞生物标志物将被 由核心病理学家解释。此外，动物研究标本处理、组织病理学、IHC 和 将提供病理解释支持。总的来说，核心的主要功能在 以下目标： 1) 全面采集、处理、存储、编目和分配组织、细胞和血液 相关临床病理数据； 2) 提供肺部肿瘤的病理和分子遗传学分类 免疫组织化学染色结果的解释； 3) 促进基于人体组织的孢子研究 研究项目； 4) 支持管理核心发起的 SPORE 内、SPORE 间协作 合作，以及我们自己和其他机构（包括其他同行）的研究人员之间的合作 审查了 NCI/NIH 和其他机构资助的使用 SPORE 产生的组织的项目。