FEAR LEARNING IN MICE AND DISORDERS OF FEAR IN HUMANS

小鼠的恐惧学习和人类的恐惧障碍

• 批准号: 7958196
• 负责人: KERRY J. RESSLER
• 金额: $ 4.39万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958196
• 关键词: Amygdaloid structure; Brain-Derived Neurotrophic Factor; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Cycloserine; Disease; Extinction (Psychology); Fright; Funding; Gene Expression; Grant; Human; Institution; Learning; Lentivirus Vector; Macaca; Mediating; Medical center; Mus; N-Methyl-D-Aspartate Receptors; N-Methylaspartate; Post-Traumatic Stress Disorders; Primates; Reporting; Research; Research Personnel; Resources; Role; Source; United States National Institutes of Health; Work; gene therapy; medical schools; pilot trial; receptor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. During the reporting period, we continued to examine NMDA function in mice through the use of a 'floxed' inducible deletion NMDA receptor subunit 1 mouse line. We focused on NMDA subtypes and the localization of gene expression of NMDA2b, 2c, and type 1 receptors. Our previous work on the plasticity factor, BDNF, and its role along with NMDA in mediating plasticity of fear and extinction of fear continued throughout the year as well. Our collaboration is ongoing with the School of Medicine where we assisted with a treatment study for D-cycloserine augmentation of treatment for PTSD at Emory and the Atlanta VA Medical Center. Pilot trials for gene therapy approaches using lentiviral vectors in the Macaque amygdala have begun with anticipated results this spring.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在报告期间，我们通过使用“诱发的”诱导删除NMDA受体亚基1小鼠系列继续检查小鼠中NMDA功能。 我们专注于NMDA亚型以及NMDA2B，2C和1型受体的基因表达的定位。 我们以前关于可塑性因素BDNF及其作用以及NMDA在整个一年中介导恐惧和恐惧的可塑性中的作用。 我们与医学院的合作正在进行中，在那里我们协助进行了一项治疗研究，以增加埃默里（Emory）和亚特兰大VA医疗中心（Atlanta VA）医学中心的PTSD治疗。 使用猕猴杏仁核中使用慢病毒载体的基因治疗方法的试验试验已经开始，今年春季的结果预期结果。