WATER SOLUABLE NUTRIENT ABSORPTION

水溶性养分吸收

• 批准号: 7958745
• 负责人: WILLIAM H KARASOV
• 金额: $ 4.68万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7958745
• 关键词: Animals; Cells; Chemicals; Computer Retrieval of Information on Scientific Projects Database; Digestive Physiology; Drug Kinetics; Ecology; Funding; Grant; Human; Institution; Measures; Mediating; Membrane Transport Proteins; Nutrient; Nutritional; Pathway interactions; Pharmaceutical Preparations; Physiological; Primates; Publications; Reporting; Research; Research Personnel; Resources; Services; Small Intestines; Source; Techniques; Testing; Toxicology; Toxin; United States National Institutes of Health; Water; Wisconsin; absorption; falls; nonhuman primate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To better understand the digestive physiology of non-human primates by measuring the extent of passive absorption of water-soluble nutrients. This project has important implications for understanding the digestive physiology of humans and non-human primates, and also for understanding vertebrate nutritional ecology and toxicology. Many nutrients, natural toxins and synthetic toxins and drugs are hydrosoluble. Efficient transport of hydrosoluble chemicals across the vertebrate small intestine likely depends on membrane transport proteins (mediated transport); however, some animals can efficiently transport these chemicals through the gaps between cells (i.e., by a passive, paracellular pathway). We used physiological and pharmacokinetic techniques to test the extent of passive absorption in primates. This study began during the fall of 2003 and was completed by December of 2005. This research used WNPRC Animal Services. Funding ended before this reporting period. One publication is pending in 2009.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 目的：通过测量水溶性营养素的被动吸收程度，更好地了解非人类灵长类动物的消化生理。 该项目对理解人类和非人类灵长类动物的消化生理以及了解脊椎动物营养生态学和毒理学具有重要意义。许多营养素，天然毒素和合成毒素和药物都是氢糖。水溶液化学物质在脊椎动物小肠道上的有效运输可能取决于膜转运蛋白（介导的转运）；但是，有些动物可以通过细胞之间的间隙（即，通过被动的细胞细胞途径）有效地运输这些化学物质。我们使用生理和药代动力学技术来测试灵长类动物中被动吸收的程度。这项研究始于2003年秋季，于2005年12月完成。这项研究使用了WNPRC动物服务。 资金在此报告期之前结束。一份出版物在2009年正在等待。