A smart fiber optic sensor for in vivo tissue optical spectroscopy

用于体内组织光谱的智能光纤传感器

• 批准号: 7978402
• 负责人: Bing Yu
• 金额: $ 7.85万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7978402
• 关键词: Affect; Arts; Calibration; Cervical; Cervix Uteri; Consumption; Country; Coupling; Data Analyses; Death Rate; Dependence; Detection; Developing Countries; Devices; Diagnostic; Diffuse; Early Diagnosis; Environment; Epithelial; Evaluation; Fiber; Fiber Optics; Future; Gases; Goals; Grant; Haiti; Hospitals; Incidence; Light; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Measurement; Measures; Medical; Metric; Modeling; Optics; Oral; Oral Diagnosis; Oral cavity; Oral mucous membrane structure; Outcome; Patients; Performance; Physiological; Physiology; Power Sources; Premalignant; Process; Property; Public Health; Research; Research Infrastructure; Resolution; Resources; Sampling; Screening procedure; Site; Source; Spectrum Analysis; Staging; System; Technology; Test Result; Testing; Time; Tissue Extracts; Tissue Sample; Tissues; Validation; Variant; Woman; Work; absorption; cancer diagnosis; charge coupled device camera; cost; design; design and construction; global health; healthy volunteer; in vivo; innovation; instrument; laptop; malignant mouth neoplasm; mortality; oral tissue; photonics; pressure; programs; public health relevance; response; sensor; soft tissue; tissue phantom; volunteer

DESCRIPTION (provided by applicant): Cancer, such as oral and cervical cancer, is a growing global health problem that disproportionately impacts the developing world. Each year, over 481,000 new cases of oral cancer are diagnosed worldwide, with a 5- year mortality of ~50% and nearly two-thirds of which occurs in developing world. Cervical cancer is the second most common cancer in women with an incidence and death rate of 16 and 9 per 100,000 women, respectively, and 80% of cases occur in the developing world. The high death rate in developing countries is largely due to the fact that these countries do not have the appropriate infrastructure and resources to support the organized screening and diagnostic programs that are available in the U.S. The optical absorption and scattering properties of epithelial tissues reflect their underlying physiological and morphological properties. Optical spectroscopy, particularly diffuse reflectance spectroscopy, can be used to noninvasively quantify these tissue properties and has shown promise for diagnosis of early precancerous changes in the cervix and oral cavity by our group as well as others. The long term objective of this proposal is to develop a portable, easy-to-use and low cost, yet accurate and reliable optical device that can aid in the screening and diagnosis of oral and cervical cancer at an early stage and that is well suited for use in a low-resource setting. The objective of the proposed research is to develop a portable, low-power consumption, smart fiber-optic sensor and to establish its performance metrics on tissue-mimicking phantoms and healthy oral tissues. The goals will be achieved by the use of state-of-the-art photonics components, such as LEDs and USB spectrometers, and an innovative smart fiber-optic probe. The smart probe will integrate into a single fiber-optic probe a sample channel for tissue optical spectroscopy, a self-calibration channel for real-time instrument calibration, and an interferometric pressure sensor for the control of the probe pressure at the probe-to-tissue interface. The specific aims of the proposed work are: (1) design and construction of the smart sensor system for performing visible diffuse reflectance spectroscopy of epithelial tissues in vivo; (2) verification of the accuracy of the smart sensor system in extraction of optical properties on tissue phantoms and in measuring pressure in a pressure test chamber; and (3) an evaluation of the effects of probe pressure on the measured tissue parameters and how well the probe pressure can be controlled with the smart sensor in healthy volunteers. Successful completion of the objectives of this research will result in a compact smart fiber-optic sensor system which will be demonstrated to obtain accurate, reproducible and quantitative measurements of tissue absorption and scattering contrast with applications to global health screening of cervical and oral cancers. Future research efforts will focus on deploying this technology for testing early screening strategies in resource poor environments. Dr. Ramanujam with whom the PI collaborates has a Duke Global health grant to initiate optical spectroscopy studies on patients suspected to have cervical cancer in Haiti. PUBLIC HEALTH RELEVANCE: The goal of this R03 proposal is to develop a portable, low power-consumption, and low-cost smart fiber-optic sensor device that can be used to obtain accurate, reproducible and quantitative measurements of absorption and scattering contrast of intact tissues with applications to global health screening of cervical and oral cancers. The proposed research is significantly relevant to public health due to the potential to contribute to the improvement of screening oral and cervical cancer, and thus the reduction of mortality rate worldwide.

描述（由申请人提供）：癌症，例如口腔和宫颈癌，是日益增长的全球健康问题，对发展中国家的影响不成比例。每年，全球诊断出481,000例新的口腔癌病例，5年死亡率约为50％，其中近三分之二发生在发展中国家。宫颈癌是女性第二大最常见的癌症，其发病率和死亡率分别为每100,000名女性16和9，并且80％的病例发生在发展中国家。发展中国家的高死亡率很大程度上是由于这些国家没有适当的基础设施和资源来支持美国可用的有组织的筛查和诊断计划。上皮组织的光吸收和散射特性反映了其潜在的生理和形态特性。光谱法，尤其是弥漫性反射光谱，可用于非侵入性地量化这些组织特性，并显示出有望诊断我们组以及其他人以及其他人以及其他人的早期癌前变化。该提案的长期目标是开发一种易于使用的，易于使用和低成本，但准确且可靠的光学设备，可以在早期阶段筛查和诊断口腔和宫颈癌，并且非常适合在低资源环境中使用。拟议的研究的目的是开发便携式，低功率消耗，智能光纤传感器，并在模仿组织的幻影和健康的口腔组织上建立其性能指标。这些目标将通过使用最先进的光子组件（例如LED和USB光谱仪）以及创新的智能光纤探针来实现。 SMART探针将集成到单个光纤探针中，用于组织光谱的样品通道，实时仪器校准的自校准通道以及用于控制探针到组织界面处探针压力的干涉压力传感器。拟议工作的具体目的是：（1）设计和构建智能传感器系统，用于在体内对上皮组织进行可见的弥散反射光谱； （2）验证智能传感器系统在组织幻像上提取光学性质的准确性以及在压力测试室中测量压力的精度； （3）评估探针压力对测得的组织参数的影响，以及在健康志愿者中用智能传感器控制探针压力的能力。成功完成这项研究的目标将导致一个紧凑的智能光纤传感器系统，该系统将被证明可以获得对组织吸收的准确，可重现和定量测量，并与在颈椎和口服癌症的全球健康筛查中的应用形成鲜明对比。未来的研究工作将着重于部署这项技术来测试资源较差的环境中的早期筛查策略。 PI合作的Ramanujam博士获得了杜克大学全球健康赠款，以对涉嫌在海地患有宫颈癌的患者进行光谱研究。 公共卫生相关性：该R03提案的目的是开发一种可移植，低功耗和低成本的智能光纤传感器设备，可用于获得完整，可再现和定量的吸收和散射对比的准确，可再现和定量的测量，以与完整的组织相比，与筛分和口腔癌的全球健康筛查相比。拟议的研究与公共卫生非常相关，因为有可能有助于改善口腔和宫颈癌的改善，从而降低了全球死亡率。