Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV

测试针对艾滋病毒感染者的适应能力建设干预措施的功效和机制

基本信息

批准号：
10702035
负责人：
Pariya Fazeli Wheeler
金额：
$ 4.11万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-15 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10702035
关键词：
Address Affect African American Aging Behavior Black race Buffers Complement Data Data Analyses Data Collection Data Set Development Development Plans Elderly Enrollment Ensure First Generation College Students Future Goals Grant HIV Health Intervention Measures Medical Mentors Mexican Americans Outcome Parents Participant Personality Persons Population Positioning Attribute Prevention strategy Protocols documentation Race Reaction Research Research Training Resources Sampling Severities Stress Stressful Event Testing Time Training Trauma Treatment Efficacy Work adverse childhood events career career development comorbidity data dissemination doctoral student efficacy testing experience hands on research health disparity innovation interest promote resilience psychologic racial difference racial disparity resilience sociodemographics stress reactivity stressor

项目摘要

PROJECT SUMMARY/ABSTRACT The purpose of this Diversity Supplement is to provide Mr. Jeremy Delgadillo, a Mexican American first- generation college graduate and first-year PhD student, research experience and training to promote his career development. This supplement will be nested in Dr. Pariya Wheeler’s R21 grant “Testing the Efficacy and Mechanisms of an Adapted Resilience Building Intervention in People Aging with HIV” (R21 AG076377- 01A1). The goal of the parent study is to test an adapted resilience intervention among 100 older PLHIV. This proposal is particularly innovative due to its use of the real-time ESM approach to assess intervention efficacy and mechanisms. Mr. Delgadillo will be positioned to leverage the rich baseline dataset from this parent R21 study to examine several important temporal associations between stress reactivity, resilience resources, and health outcomes among older PLWH. The baseline data collection will be complete within 1 year, allowing Mr. Delgadillo to engage in data analysis and dissemination in Year 2. Specifically, he will have baseline data on 100 PLHIV, which includes an extensive assessment to measure sociodemographics and stressful life events/trauma, health variables (e.g., comorbidities, HIV medical parameters), psychological functioning, and HIV treatment management. Furthermore, the baseline data will also include a 14-day ESM protocol that queries participants on stressful events, use of resilience resources, and affect. Importantly, given the diverse sample of ~50% African American/Black PLHIV that will be enrolled in this R21, Mr. Delgadillo will be well positioned to examine racial differences that may emerge in the findings, which aligns with his interests in racial and health disparities. Together, this rich dataset will allow Mr. Delgadillo to examine the following aims: AIM 1: To examine person-factors (e.g., race, SES, personality) as well as factors related to lifetime stress (e.g., lifetime adversity and adverse childhood events) and momentary stress (e.g., severity) as predictors of use of resilience resources (both global use and use of specific resources) following stressors. AIM 2: To examine whether specific resilience resources better predict stress reactivity, and whether resilience resources in turn predict better health outcomes (i.e., psychological functioning and HIV outcomes). Impact: These research findings will fill a significant gap in the field on understanding how PLWH react following stressors and how these behaviors impact health outcomes, which will inform the development of both prevention and intervention strategies. Importantly, these results will supplement and complement the results from the primary aims of the parent study that will assess intervention efficacy and mechanisms. The research training and career development plan proposed by Mr. Delgadillo and his mentoring team will ensure he is able to succeed in his future career, and will also prepare him to submit a successful F31 application at the end of the supplement.

项目概要/摘要本多样性补充材料的目的是为墨西哥裔美国人 Jeremy Delgadillo 先生提供—— 一代大学毕业生和一年级博士生，研究经验和培训以促进他的该补充品将纳入 Pariya Wheeler 博士的 R21 资助“测试功效”中。艾滋病毒感染者的适应力建设干预措施的机制”（R21 AG076377- 01A1)。家长研究的目标是在 100 名老年艾滋病毒感染者中测试适应性恢复干预措施。该提案特别具有创新性，因为它使用实时 ESM 方法来评估干预效果 Delgadillo 先生将能够利用该母公司丰富的基线数据集。 R21 研究旨在检验压力反应性和复原力之间的几个重要的时间关联资源和老年 PLWH 的健康结果基线数据收集将在 1 年内完成。年，让 Delgadillo 先生在第二年从事数据分析和传播。具体来说，他将 100 名艾滋病毒感染者的基线数据，其中包括广泛的评估，以衡量社会人口统计学和压力性生活事件/创伤、健康变量（例如合并症、艾滋病毒医疗参数）、心理此外，基线数据还将包括 14 天的 ESM。询问参与者压力事件、弹性资源的使用和影响的协议。考虑到将纳入 R21 的约 50% 非洲裔美国人/黑人艾滋病病毒感染者的多样化样本，先生。德尔加迪略将能够很好地研究研究结果中可能出现的种族差异，这这些丰富的数据集与德尔加迪洛先生对种族和健康差异的兴趣相一致。检查以下目标：目标 1：检查人因素（例如种族、社会经济地位、个性）以及与终生压力（例如，终生逆境和不良童年事件）和暂时压力相关的因素（例如，严重性）作为复原力资源使用（全球使用和特定资源使用）的预测因素目标 2：检查特定的弹性资源是否可以更好地预测压力反应性，以及复原力资源是否反过来可以预测更好的健康结果（即心理功能和艾滋病毒影响：这些研究结果将填补该领域在了解 PLWH 如何理解方面的重大空白。对压力源做出反应以及这些行为如何影响健康结果，这将为发展提供信息重要的是，这些结果将补充和补充预防和干预策略。来自母研究主要目标的结果，该研究将评估干预效果和机制。 Delgadillo先生及其导师团队提出的研究培训和职业发展计划将确保他能够在未来的职业生涯中取得成功，并为他在以下地址提交成功的 F31 申请做好准备：补充结束。