Stress Reactivity and Low Back Pain in Older Adults: Influences on Disability (ReLOAD)

老年人的应激反应和腰痛：对残疾的影响 (ReLOAD)

• 批准号: 10701668
• 负责人: Corey Simon
• 金额: $ 23.91万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10701668
• 关键词: Acute; Address; Adrenal Glands; Affect; Aging; Behavior Therapy; Behavioral Model; Biological Markers; Blood; Capsicum; Cardiovascular Diseases; Career Mobility; Chronic; Clinical; Clinical Trials; Clinical Trials Design; Cognitive; Cohort Studies; Coping Behavior; Coping Skills; Data; Dedications; Development; Disease; Elderly; Enrollment; Exposure to; Feeling; Funding; Gait speed; Geriatrics; Goals; Granulocyte-Macrophage Colony-Stimulating Factor; Hydrocortisone; Hypothalamic structure; Individual; Inflammatory; Interleukin-6; International; Intervention; Interview; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Link; Low Back Pain; Measurement; Measures; Mediating; Mentorship; Monitor; Movement; Neurodegenerative Disorders; Outcome; Pain; Pain Research; Participant; Patient Outcomes Assessments; Patient Self-Report; Peripheral; Physical Function; Physical activity; Physiological; Pilot Projects; Pituitary Gland; Population; Positioning Attribute; Principal Component Analysis; Procedures; Prospective Studies; Questionnaires; Rehabilitation therapy; Reporting; Research; Research Design; Research Personnel; Rotation; Safety; Sampling; Science; Self Efficacy; Serum; Spinal; Stress; Stress Tests; Stressful Event; Structure; Testing; Thinking; Time; Trier Social Stress Test; United States National Institutes of Health; Vertebral column; Walking; Work; biobehavior; biological adaptation to stress; career; career development; coping; cytokine; disability; disability risk; efficacy testing; innovation; mindfulness; mortality; novel; overtreatment; pain catastrophizing; physical therapist; poor health outcome; programs; psychologic; psychological distress; response; stem; stress reactivity; stressor; therapeutic biomarker; therapy development

PROJECT SUMMARY/ABSTRACT This application for the Paul B. Beeson Emerging Leaders Career Development Award in Aging (K76) is for Dr. Corey Simon, a physical therapist and geriatric pain researcher specializing in low back pain. Low back pain is one of the world’s most disabling conditions for older adults, with more than 75% reporting persistent disability 1-2 years after onset. A novel disability mechanism among older adults with low back pain is high stress reactivity, which is an acute physiologic response characterized by abnormal changes in blood biomarkers after stressful encounters. High stress reactivity is linked to poorer health outcomes including disability in other chronic conditions; and accumulating research suggests high stress reactivity is mediated by abnormal thoughts and feelings and is modifiable through biobehavioral interventions. However, stress reactivity research in older adults with low back pain is lacking. This proposal in an innovative 5-year research program that builds upon Dr. Simon’s pilot study demonstrating exciting preliminary associations between stress reactivity, physical function, and psychological distress. This proposal will utilize novel laboratory stress reactivity tests, patient-reported outcomes, and qualitative interviews to: 1) Identify and quantify stress reactivity in older adults with low back pain; and 2) For the purpose of reducing disability risks, develop a biobehavioral intervention that targets high stress reactivity in older adults with low back pain. This program will test his central hypothesis that older adults with low back pain and high stress reactivity are at greater risk for disability due to negative thoughts and feelings and poor coping strategies. In addition, this program will provide Dr. Simon with advanced career development in stress reactivity science, behavioral intervention development, and research leadership. Upon completion of this program, Dr. Simon will be poised to facilitate the development of an NIA-funded clinical trial (R34/R01) to test the efficacy of his innovative biobehavioral rehabilitation intervention for older adults with low back pain that targets high stress reactivity. Collectively, this program is the next step in Dr. Simon’s long-term goal to become an international leader in the development of targeted interventions to eradicate disability in older adults with low back pain.

项目概要/摘要 保罗·比森 (Paul B. Beeson) 老年新兴领袖职业发展奖 (K76) 的申请适用于 Corey Simon 博士是一位物理治疗师和老年疼痛研究员，专门研究腰痛。 疼痛是世界上最令老年人丧失能力的病症之一，超过 75% 的人表示持续存在疼痛 发病后 1-2 年内的一种新的残疾机制在患有腰痛的老年人中很高。 应激反应，是一种以血液异常变化为特征的急性生理反应 遭遇压力后的生物标志物与较差的健康结果有关，包括 其他慢性疾病导致的残疾；并且不断积累的研究表明，高应激反应是由以下因素介导的： 异常的想法和感受可以通过生物行为干预来改变。 这项为期 5 年的创新研究中缺乏针对老年人腰痛的反应性研究。 该计划以西蒙博士的试点研究为基础，该研究证明了两者之间令人兴奋的初步关联 该提案将利用新型实验室压力。 反应性测试、患者报告的结果和定性访谈，目的是： 1) 识别和量化压力 患有腰痛的老年人的反应性；以及 2) 为了降低残疾风险，制定 该计划将针对患有腰痛的老年人的高应激反应性进行生物行为干预。 检验他的中心假设，即患有腰痛和高应激反应的老年人面临更大的风险 此外，该计划还将因消极的想法和感受以及不良的应对策略而导致残疾。 为西蒙博士提供应激反应科学、行为干预方面的高级职业发展 完成该计划后，西蒙博士将做好促进工作的准备。 开发 NIA 资助的临床试验 (R34/R01)，以测试其创新生物行为的功效 总的来说，这是针对高压力反应性的腰痛老年人的康复干预。 该计划是西蒙博士长期目标的下一步，即成为开发领域的国际领导者 有针对性的干预措施，以消除患有腰痛的老年人的残疾。

项目成果

The Psychologically Informed Practice Consultation Roadmap: A Clinical Implementation Strategy.

心理知情实践咨询路线图：临床实施策略。

• 发表时间: 2023-07-01
• 影响因子: 3.2
• 作者: Main, Chris J;Simon, Corey B;Beneciuk, Jason M;Greco, Carol M;George, Steven Z;Ballengee, Lindsay A
• 通讯作者: Ballengee, Lindsay A

Psychologically Informed Practice: The Importance of Communication in Clinical Implementation.

心理知情实践：沟通在临床实施中的重要性。

• 发表时间: 2023-07-01
• 影响因子: 3.2
• 作者: Main, Chris J;Ballengee, Lindsay A;George, Steven Z;Beneciuk, Jason M;Greco, Carol M;Simon, Corey B
• 通讯作者: Simon, Corey B