Drug Dependence Clinical Research Program
药物依赖性临床研究计划
基本信息
- 批准号:8288911
- 负责人:
- 金额:$ 60.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1999
- 资助国家:美国
- 起止时间:1999-09-01 至 2015-06-30
- 项目状态:已结题
- 来源:
- 关键词:AdenosineAlcoholsAlkaloidsAnalytical ChemistryBiological AssayCaffeineCancer Grant Supplements (P30)ClinicClinical PharmacologyClinical PsychologyClinical ResearchCocaineConsultData AnalysesDisciplineDrug AddictionDrug KineticsDrug abuseDrug usageEphedraFundingGrantHealthHumanIndividualInstitutionInstitutional Review BoardsInternal MedicineLabelLaboratoriesManuscriptsMeasuresMethamphetamineNeurologyNicotineOpiatesOrganic ChemistryPediatricsPersonsPharmaceutical ChemistryPharmaceutical PreparationsPharmacy facilityPhenethylaminesPreparationPsychiatryPsychopharmacologyPsychotropic DrugsRequest for ApplicationsResearchResearch DesignResearch InfrastructureResearch PersonnelResearch Project GrantsResourcesServicesSourceSynthesis ChemistryToxicogeneticsUnited States National Institutes of Healthaddictionanalytical methodcost effectivedrug abuse chemotherapydrug addictecstasyeffective therapygamma hydroxybutyrateheart pharmacologyinnovationinterestneurosteroidsprogramsstatisticstreatment strategy
项目摘要
DESCRIPTION (provided by applicant): This Core Support Center Grant (P30) application requests continued support for an analytic and synthetic chemistry laboratory and administrative shared core infrastructure. The participating, currently funded, constituent projects continue research programs with human laboratory and treatment clinic studies of the clinical pharmacology of abused drugs, pharmacotherapies and other treatment strategies to treat drug abuse and addictions. Drugs of interest to participating projects and assays available include nicotine and its metabolites, cocaine, methamphetamine and other phenethylamines, alcohol, MDMA, ephedra alkaloids, caffeine, gamma hydroxybutyrate (GHB), salvinorin, adenosine, and neurosteroids, and opiates. Analytical methods have been developed and validated in the core analytic laboratory to support studies with these drugs. Other new assays and labeled (deuterated) compounds will be made available to the associated research projects as needed. Disciplines represented by the participating projects and investigators include psychiatry, clinical psychology, neurology, general internal medicine, cardiology and clinical pharmacology, psychopharmacology, toxicology, genetics, pediatrics, pharmacy, organic, medicinal and analytical chemistry, and statistics. Our aims are: (1) to provide a state-of-the-art well equipped and staffed, analytical and synthetic chemistry laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. (2) To provide administrative support for manuscript preparation, IRB and related regulatory documents, grants management, and other research administrative services of value participating projects. (3) To provide statistical consulting services regarding study design and data analysis strategies, particularly optimal pharmacokinetic analysis to participating projects. The overall objective is to provide sophisticated analytic laboratory resources with stability of support together with adequate administrative support responsive to the needs of individual funded constituent scientific projects as those projects change and evolve. This facility is a cost-effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.
描述(由申请人提供):此核心支持中心赠款(P30)申请请求继续支持分析和合成化学实验室和行政共享核心基础设施。参与的,目前由资助的组成项目通过人类实验室和治疗诊所研究滥用药物,药物治疗和其他治疗药物滥用和成瘾的治疗策略,继续研究计划。参与项目和分析的感兴趣药物包括尼古丁及其代谢产物,可卡因,甲基苯丙胺和其他苯乙胺,酒精,MDMA,麻黄碱,咖啡因,咖啡因,伽玛羟基丁酸(GHB)(GHB)(GHB),咸核酸盐,咸酸盐,腺苷和腺苷和神经蛋白酶和Opiatess和Opiatess和Opiatess和Opiatess和Opiatess。在核心分析实验室中已经开发和验证了分析方法,以支持这些药物的研究。其他新测定和标记(剥离)化合物将根据需要提供给相关的研究项目。由参与项目和研究者代表的学科包括精神病学,临床心理学,神经病学,通用内科,心脏病学和临床药理学,心理药理学,毒理学,遗传学,儿科,药房,有机,药物,药物和分析化学和统计学。我们的目标是:(1)为UCSF和其他机构提供最先进的设备齐全,配备良好的,分析和合成化学实验室资源。 (2)为手稿准备,IRB和相关监管文件,赠款管理以及其他价值参与项目的其他研究行政服务提供行政支持。 (3)提供有关研究设计和数据分析策略的统计咨询服务,尤其是针对参与项目的最佳药代动力学分析。总体目的是为了稳定支持提供复杂的分析实验室资源,并随着这些项目的变化和发展,应对个人资助的成分科学项目的需求有足够的行政支持。该设施是一种具有成本效益的共享实验室资源,可增强和扩展由NIH或其他联邦或非联邦或非联邦资助资源资助的研究人员的研究可能性,以进一步我们对人类精神毒品的使用,滥用和成瘾,其健康后果及其治疗管理的理解。
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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- 批准号:
8662548 - 财政年份:2014
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$ 60.87万 - 项目类别:
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