Development and Use of rtfMRI for Self-control of Nicotine Craving

rtfMRI 的开发和使用用于自我控制尼古丁渴望

基本信息

批准号：
8282904
负责人：
Mark K Greenwald
金额：
$ 53.31万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-15 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8282904
关键词：
Accounting Algorithms Anterior Area Auditory area Biological Brain Brain region Cerebrovascular Circulation Characteristics Chronic Disease Cigarette Classification Clinical Cocaine Computer software Data Data Set Development Disease Drug Addiction Elements Evaluation Feedback Functional Magnetic Resonance Imaging Future General Population Goals Individual Individual Differences Instruction Insula of Reil Investigation Knowledge Lead Learning Location Machine Learning Measurement Measures Methodology Methods Modeling Nicotine Nicotine Dependence Opiates Outcome Pain Patients Pattern Performance Pharmaceutical Preparations Placebo Control Placebo Effect Placebos Prevalence Procedures Process Public Health Real-Time Systems Recurrence Regression Analysis Reproducibility Sampling Self-control as a personality trait Signal Transduction Solutions Spin Labels Substance Use Disorder Substance of Abuse Techniques Testing Time Training Training Technics Treatment outcome Variant abstracting addiction alternative treatment base blood flow measurement blood oxygen level dependent cingulate cortex craving expectation experience hemodynamics heuristics improved interest mathematical model multidisciplinary neurofeedback nicotine craving reconstruction relating to nervous system research study response substance abuse treatment vector visual feedback visual motor volunteer

项目摘要

Project Summary Abstract This proposal aims to study the application of functional magnetic resonance imaging in real time (rtfMRI) as an operant training feedback mechanism for treating substance use disorders. Recent data suggest that individuals can reduce activity in some brain regions (e.g. anterior cingulate cortex, anterior insula, auditory cortex when they are presented with information about activation in that brain region. Experimental and clinical pain have been reduced with rtfMRI signal feedback from the rostral anterior cingulate in a manner proportional to reductions in the blood oxygenation level dependent (BOLD) signal from that region. These regions overlap with those involved in the effets of substances of abuse and the development of substance use disorders (SUDs). The initial information opens the possibility of applying neurofeedback to improve treatment outcomes in patient samples. The present application seeks to expand the investigation of these processes and validate their applicability to substance dependent volunteers. In initial studies we will examine the capacity of nicotine dependent volunteers to reduce their craving for cigarettes. This substance was selected for its high retention rates and prevalence and public health burden in the general population, but it is expected that future studies would explore other forms of addiction (e.g. cocaine, opiates). Our multidisciplinary team proposes to advance current knowledge in this area by: (1) using data not from a single brain region, but from networks involved in nicotine craving and dependence, thereby accounting for inter- individual differences in brain regional activation patterns during nicotine craving; (2) developing a quantifiable method by using arterial spin labeling (ASL); and (3) determining the influence of individual expectations on these processes (e.g. assessing the degree to which these effects are attributable to placebo-related responding). The developmental and experimental elements of this proposal will lead to new avenues for treatment that would be readily generalizable to other forms of drug addiction besides nicotine, and potentially impacting on the outcomes of the substantial numbers of individuals seeking substance abuse treatment.

项目概要摘要本提案旨在研究功能磁共振成像的实时应用（rtfMRI）作为治疗物质使用障碍的操作训练反馈机制。最近的数据表明，个体可以减少某些大脑区域的活动（例如前扣带皮层、前岛叶、听觉皮层收到有关大脑激活的信息时地区。来自吻侧的 rtfMRI 信号反馈减少了实验和临床疼痛前扣带回的减少与血氧水平相关（粗体）来自该区域的信号。这些区域与涉及物质作用的区域重叠滥用和物质使用障碍（SUD）的发展。初始信息打开应用神经反馈来改善患者样本治疗结果的可能性。现在的应用程序旨在扩大对这些过程的调查并验证它们的适用性物质依赖志愿者。在初步研究中，我们将检查尼古丁依赖的能力志愿者减少对香烟的渴望。该物质因其高保留率而被选中一般人群中的发病率、患病率和公共卫生负担，但预计未来研究将探索其他形式的成瘾（例如可卡因、阿片类药物）。我们的多学科团队提出通过以下方式推进该领域的当前知识：（1）使用并非来自单个大脑区域的数据，但来自涉及尼古丁渴望和依赖的网络，从而解释了相互之间的关系渴望尼古丁时大脑区域激活模式的个体差异； (2) 开发一个使用动脉自旋标记（ASL）的可量化方法； (3) 确定影响对这些过程的个人期望（例如评估这些影响的程度）归因于安慰剂相关的反应）。该项目的开发和实验要素该提案将带来新的治疗途径，这些途径很容易推广到其他形式的治疗除尼古丁外的药物成瘾，并可能影响大量患者的结果寻求药物滥用治疗的个人。