Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 8107655
• 负责人: Bernhard H. Weigl
• 金额: $ 147.42万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8107655
• 关键词: Center; Advance; POC; Diagnostics; Global; Center; Advance; POC; Diagnostics; Global

DESCRIPTION (provided by applicant): The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

描述（由申请人提供）： 使用适当的护理点（POC）诊断测试可能意味着右边的差异 治疗或持续的疾病或死亡：在低资源环境（LRS）中，尤其是在发展中国家，诊断能力很小，不足或不存在。专门为LRS设计的新的和创新的POC诊断技术将对全球公共卫生产生重大影响：提供及时，适当的患者治疗，减少药物的过度处方，限制耐药性的传播并提高对潜在大流行病的早期警报。诊断技术的新兴技术提供了解决LRS中许多临床未满足需求的机会。 Path，是经济实惠且适当的诊断测试发展的国际领导者及其 合作伙伴正在提出一个中心，以推进全球健康（中心）的护理点诊断。在五年的时间里，该中心将加速对LRS必不可少的POC诊断测试的开发和部署：对最多五个选定的Prototype POC POC诊断测试进行实验室和现场的临床评估（CORE 1）；将多达四种创新和有希望的技术识别和选择作为POC诊断测试（CORE 2）；在相关资源有限的设置中对与POC诊断有关的关键临床需求进行评估（CORE 3）；提供一项严格的培训计划，以教育技术开发人员，研究人员，科学家和工程师，包括私营部门公司的研究人员，以提供LRS提供医疗保健的现实（Core 4）；最后，通过一个强大的综合管理团队协调活动，并与所需的机构支持（技术，设施，行政，财务，法律和后勤）进行协调（核心5）。通过培训和生成所有核心活动的手册，教程和标准操作程序，以及对需求评估和研究传播的严格计划，该中心的影响将超出其五年的持续时间。 该中心由华盛顿大学全球卫生系（UW）全球卫生系的合作作为培训核心的领导者，在训练核心的领导下，将在加速POC加速和引入诊断测试中发挥核心作用。 Path在产品开发，现场测试和介绍过程的各个阶段与公共和私营部门合作伙伴合作的独特而丰富的经验，以及UW在LRS培训方面的经验，为项目的最终目标提供理想的支持：通过提高全球服务不足人群的健康状况，通过增加可用性，可访问性，可访问性，可访问性PIC诊断性诊断。