Center to Advance POC Diagnostics for Global Health

全球健康 POC 诊断推进中心

• 批准号: 7688789
• 负责人: Bernhard H. Weigl
• 金额: $ 24.19万
• 依托单位: PATH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688789
• 关键词: Acquired Immunodeficiency Syndrome; Acute; Address; Advanced Development; Affect; Agency for International Development; Biomedical Engineering; Biomedical Research; Biotechnology; Caring; Cessation of life; Clinic; Clinical; Collaborations; Communicable Diseases; Communities; Community Health; Complex; Condition; Country; Daily; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Diarrhea; Disease; Drug Prescriptions; Drug resistance; Effectiveness of Interventions; Emerging Technologies; Engineering; Environment; Evaluation; Feedback; Fever; Foundations; Future; Generations; Goals; Government; Health; Health Services; Health Technology; Health system; Healthcare; Homelessness; Income; Indian reservation; Individual; Industry; Institutes; Institution; International; Intervention; Investments; Kenya; Knowledge; Laboratories; Lead; Legal; Life; Low Income Population; Manuals; Marketing; Medical; Medicine; Methods; Mission; Monitor; Names; Nature; Needs Assessment; Outcome; Patients; Performance; Play; Population; Prevalence; Preventive; Private Sector; Procedures; Process; Provider; Public Health; Public Sector; Publishing; Recording of previous events; Recurrence; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resources; Role; Science; Scientist; Series; Site; Solutions; Staging; Standards of Weights and Measures; Symptoms; System; Technology; Testing; Therapeutic; Time; Training; Training Programs; Tropical Disease; Underserved Population; Universities; Vaginal Discharge; Washington; Work; World Health Organization; Writing; base; bioimaging; care seeking; commercialization; cost; design; evaluation/testing; experience; improved; innovation; intervention program; neglect; novel diagnostics; novel strategies; outreach; pandemic disease; performance tests; point of care; programs; prototype; research and development; research clinical testing; tool; usability; Acquired Immunodeficiency Syndrome; Acute; Address; Advanced Development; Affect; Agency for International Development; Biomedical Engineering; Biomedical Research; Biotechnology; Caring; Cessation of life; Clinic; Clinical; Collaborations; Communicable Diseases; Communities; Community Health; Complex; Condition; Country; Daily; Developed Countries; Developing Countries; Development; Devices; Diagnosis; Diagnostic; Diagnostic tests; Diarrhea; Disease; Drug Prescriptions; Drug resistance; Effectiveness of Interventions; Emerging Technologies; Engineering; Environment; Evaluation; Feedback; Fever; Foundations; Future; Generations; Goals; Government; Health; Health Services; Health Technology; Health system; Healthcare; Homelessness; Income; Indian reservation; Individual; Industry; Institutes; Institution; International; Intervention; Investments; Kenya; Knowledge; Laboratories; Lead; Legal; Life; Low Income Population; Manuals; Marketing; Medical; Medicine; Methods; Mission; Monitor; Names; Nature; Needs Assessment; Outcome; Patients; Performance; Play; Population; Prevalence; Preventive; Private Sector; Procedures; Process; Provider; Public Health; Public Sector; Publishing; Recording of previous events; Recurrence; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Resources; Role; Science; Scientist; Series; Site; Solutions; Staging; Standards of Weights and Measures; Symptoms; System; Technology; Testing; Therapeutic; Time; Training; Training Programs; Tropical Disease; Underserved Population; Universities; Vaginal Discharge; Washington; Work; World Health Organization; Writing; base; bioimaging; care seeking; commercialization; cost; design; evaluation/testing; experience; improved; innovation; intervention program; neglect; novel diagnostics; novel strategies; outreach; pandemic disease; performance tests; point of care; programs; prototype; research and development; research clinical testing; tool; usability

The use of appropriate point-of-care (POC) diagnostic tests can mean the difference between the right treatment or continued sickness or death: In low-resource settings (LRS), especially in developing countries, diagnostic capabilities are minimal, inadequate, or nonexistent. New and innovative POC diagnostic technologies designed specifically for LRS will have a major impact on global public health by: providing timely and appropriate patient treatment, reducing over-prescription of drugs, restraining the spread of drug resistance and raising early alerts of a potential pandemic disease. Emerging technologies in diagnostics offer the opportunity to address many of the clinical unmet needs in LRS. PATH, an international leader in the development of affordable and appropriate diagnostic tests, and its partners are proposing a Center to Advance Point-of-Care Diagnostics for Global Health (the Center). Over the course of five years, the Center will accelerate the development and deployment of POC diagnostic tests essential to LRS by: conducting laboratory- and field-based clinical evaluation of up to five selected prototype POC diagnostic tests (Core 1); identifying and selecting up to four innovative and promising technologies for potential development as POC diagnostic tests (Core 2); conducting assessments of the critical clinical needs related to POC diagnostics in relevant resource-limited settings (Core 3); offering a rigorous training program to educate technology developers and researchers, scientists, and engineers, including those from private-sector companies, on the realities of providing health care in LRS (Core 4); and lastly by coordinating activities through a strong, integrated management team and with the required institutional support (technical, facilities, administrative, financial, legal, and logistical) (Core 5). Through training and generation of manuals, tutorials, and standard operating procedures for the activities of all cores, and rigorous plans for dissemination of needs assessment and research, the Center will have an impact beyond its five-year duration. Managed by PATH, with collaboration from the University of Washington (UW) Department of Global Health as the lead on the training core, the Center will play a central role in accelerating the development and introduction of diagnostic tests for use at the POC. PATH'S unique and extensive experience in working with public- and private-sector partners at all stages of the product development, field testing, and introduction process, together with the UW's experience in training in LRS, provide the ideal support for the project's ultimate goal: to improve health among underserved populations worldwide by increasing the availability, accessibility, and affordability of essential POC diagnostic tests.

使用适当的护理点（POC）诊断测试可能意味着右边的差异 治疗或持续的疾病或死亡：在低资源环境（LRS）中，尤其是在发展中国家， 诊断能力最少，不足或不存在。新的和创新的POC诊断 专门为LRS设计的技术将对全球公共卫生产生重大影响：提供 及时且适当的患者治疗，减少药物的过度处方，限制药物的扩散 抵抗和提高潜在大流行病的早期警报。诊断技术的新兴技术 提供机会解决LRS中许多临床未满足需求的机会。 Path，是经济实惠且适当的诊断测试发展的国际领导者及其 合作伙伴正在提出一个中心，以推进全球健康（中心）的护理点诊断。超过 五年的过程，该中心将加速POC诊断测试的开发和部署 对LRS的必不可少 原型POC诊断测试（CORE 1）；识别和选择多达四个创新和有希望的 作为POC诊断测试的潜在发展技术（CORE 2）；进行评估 相关资源有限设置中的POC诊断相关的关键临床需求（CORE 3）；提供 严格的培训计划，以教育技术开发人员，研究人员，科学家和工程师， 包括来自私营部门公司的公司，关于在LRS提供医疗保健的现实（核心4）；和 最后，通过一个强大的综合管理团队协调活动，并与所需的 机构支持（技术，设施，行政，财务，法律和后勤）（核心5）。通过 培训和生成所有活动的手册，教程和标准操作程序 核心以及严格的需求评估和研究计划，该中心将有一个 超出其五年的影响。 由Path管理，由华盛顿大学全球卫生系合作 作为训练核心的领导，该中心将在加速发展和 引入诊断测试以在POC中使用。 Path在与之合作的独特而丰富的经验 产品开发，现场测试和简介的所有阶段的公共和私营部门合作伙伴 流程，加上UW在LRS培训方面的经验，为项目提供了理想的支持 最终目标：通过增加可用性来改善全球服务不足的人群的健康状况， 可访问性和必需POC诊断测试的可负担性。