Neurobiological study on the effects of marijuana in a unique model

独特模型中大麻影响的神经生物学研究

• 批准号: 8416478
• 负责人: Erik Benjamin Oleson
• 金额: $ 3.04万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-10 至 2013-03-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8416478
• 关键词: Acoustics; Adolescence; Adolescent; Animal Model; Animals; Behavior; Behavioral; Brain; Cues; Development; Dopamine; Exhibits; Funding; Future; Goals; Health; High Prevalence; Hippocampus (Brain); Impairment; Individual; Interest Group; Knowledge; Learning; Lesion; Literature; Marijuana; Marijuana Abuse; Marijuana Smoking; Measurement; Measures; Medical; Methods; Modeling; Monitor; National Institute of Drug Abuse; Neonatal; Neurobiology; Performance; Pharmacotherapy; Placebos; Population; Predisposition; Psychotic Disorders; Rattus; Reporting; Response Latencies; Rewards; Risk; Rodent Model; Scanning; Schizophrenia; Self Stimulation; Sensory Process; Shapes; Signal Transduction; Stimulus; Symptoms; Techniques; Testing; Time; addiction; critical developmental period; design; interest; model development; neurobiological mechanism; neurochemistry; neuromechanism; novel; prepulse inhibition; response

DESCRIPTION (provided by applicant: Adolescent marijuana-use is a prominent health concern that may confer increased susceptibility to psychosis and addiction in vulnerable individuals. We, and others, have characterized an animal model of the co-morbid development of psychosis and addiction. Here, I will test whether adolescent marijuana exposure exacerbates behavior and neurobiological adaptations occurring in this unique animal model. Two symptoms are of interest, deficits in sensorimotor gating and reward learning. I will test for deficits in sensorimotor gating using prepulse inhibition of the acoustic startle response; I will test for deficits in reward learning by measuring changes in response-latency across trials in previously described conditioned reward learning task. Both of these behaviors are known to involve subsecond dopamine signaling. Using a cutting edge neurochemical technique called fast-scan cyclic voltammetry, I will measure whether adolescent marijuana exposure changes subsecond dopamine release evoked by either acoustic-stimuli or conditioned stimuli during performance in these behavioral tasks. Our ability to detect precise changes in dopamine release accompanying the expression of psychotic symptoms will provide novel information concerning the neurobiological mechanisms through which adolescent marijuana exposure might confer increased vulnerability to psychosis and addiction.

描述（由申请人提供：青少年大麻使用是一个突出的健康问题，可能会提高对弱势群体的精神病和成瘾的敏感性。我们和其他人已经表征了一个动物模型的精神病和成瘾性发展的动物模型。在这里，我将在这种情况下侵害了这种依赖性和神经学适应性的影响，我将在这里测试青少年暴露于这种范围。感应型门控和奖励学习将对声音抑制声音响应的抑制作用。我将衡量在这些行为任务中，在表现过程中，在表现过程中，烟气刺激或条件刺激引起的青少年大麻暴露会改变多巴胺的释放。我们检测精神病症状表达的多巴胺释放中精确变化的能力将提供有关神经生物学机制的新信息，这些信息可能会通过这些信息来赋予青少年大麻暴露可能会增加对精神病和成瘾的脆弱性。