Technology-Dev-Core

技术-开发-核心

• 批准号: 10699304
• 负责人: SALLY Maureen MCFALL
• 金额: $ 118.49万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2023-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10699304
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Advisory Committees; Africa South of the Sahara; African; Anti-Retroviral Agents; Area; Award; Biological Assay; Biomedical Engineering; Businesses; Calibration; Caring; Cellular Phone; Clinical; Collaborations; Detection; Developing Countries; Development; Devices; Diagnostic; Diagnostic Errors; Diagnostic tests; Dust; Electricity; Electronic Medical Records and Genomics Network; Environmental Risk Factor; Fostering; Funding; Funding Opportunities; Goals; Grant; HIV; HIV diagnosis; HIV drug resistance; Hepatitis B; Hepatitis C; Home; Humidity; Image; Immunoassay; Incidence; Incubated; Infrastructure; Institutes; Lighting; Maintenance; Medical; Mentorship; Mission; Molecular; Monitor; National Institute of Biomedical Imaging and Bioengineering; Nigeria; Output; Pathway interactions; Patients; Performance; Persons; Pharmaceutical Preparations; Point of Care Technology; Procedures; Process; Rapid diagnostics; Reduce health disparities; Refrigeration; Research; Research Personnel; Resource-limited setting; Services; South Africa; Strategic Planning; Structure; Technology; Temperature; Testing; Time; Training; Tuberculosis; United Nations; United States National Institutes of Health; Universities; Validation; Viral; Visual; Water Supply; base; clinical practice; commercialization; community setting; comorbidity; cost; design; improved; innovation; low and middle-income countries; non-tuberculosis mycobacteria; operation; performance tests; point of care; point-of-care diagnostics; programs; prototype; recruit; research clinical testing; screening; skills training; synthetic biology; technology development; underserved community; usability; user-friendly

Summary Technology Development (Tech Dev) Core The Technology Development Core of the Center for Innovation in Point-of-Care Technologies for HIV/AIDS at Northwestern University (C-THAN) will support the development of vital POC technology specifically designed for patient management of people living with HIV in low and middle income countries with emphasis on the diagnostic needs in sub-Saharan Africa. We will support technology projects specifically designed for low resource settings with low or limited medical infrastructure such as restricted access to electricity, refrigeration and/or central water supply. A successful test will be user friendly, requiring only local training in its operation and maintenance, manufacturable at low cost with low cost consumables, rapid result, durable, contain internal checks of device/assay performance, self-calibration and error diagnosis. Projects supported by C-THAN will conform to high priority topics of HIV/AIDS research, be amenable to the conditions of low resource environments, and have high likelihood of commercialization in developing countries. A unique feature of C- THAN is our commitment to fostering local technology development in LMICs by providing specific funding opportunities for home-grown solutions via coordinated efforts to specifically incubate POC technology for HIV care in LMICs. This goal is supported by our access to a network of emerging African biomedical engineering programs through our partners in Nigeria and South Africa. We will build a robust pipeline of POC technology by identifying diagnostic needs, recruiting projects that meet those needs, monitoring progress made in funded projects, providing services and mentorship to guide projects to maturity, and facilitating the transfer of projects for clinical evaluation. The output will be a pipeline of products of high clinical impact developed from a well- balanced research portfolio originating from the Technology Development Core.

摘要 技术开发（Tech Dev）核心 艾滋病毒/艾滋病即时护理技术创新中心的技术开发核心 西北大学 (C-THAN) 将支持专门设计的重要 POC 技术的开发 对低收入和中等收入国家的艾滋病毒感染者进行患者管理，重点是 撒哈拉以南非洲地区的诊断需求。我们将支持专门为低收入群体设计的技术项目 医疗基础设施薄弱或有限的资源环境，例如电力、制冷的使用受到限制 和/或中央供水。成功的测试将是用户友好的，只需要进行本地操作培训 和维护，可以低成本制造，低成本消耗品，快速结果，耐用，包含内部 检查设备/测定性能、自校准和错误诊断。 C-THAN 支持的项目将 符合艾滋病毒/艾滋病研究的优先主题，适应资源匮乏的条件 环境，并且在发展中国家商业化的可能性很高。 C的独特之处在于—— THAN 是我们通过提供特定资金促进中低收入国家本地技术发展的承诺 通过协调努力专门孵化针对艾滋病毒的 POC 技术，获得本土解决方案的机会 中低收入国家的护理。这一目标得到了我们对新兴非洲生物医学工程网络的支持 通过我们在尼日利亚和南非的合作伙伴开展的计划。我们将建立一个强大的POC技术管道 通过确定诊断需求、招募满足这些需求的项目、监测资助的进展情况 项目，提供服务和指导以指导项目成熟，并促进项目转移 用于临床评估。产出将是一系列具有高度临床影响的产品，这些产品是由一个良好的 源于技术开发核心的平衡研究组合。