THE GENETICS AND MULTI-OMICS SPECIMENS CORE (GMSC)

遗传学和多组学样本核心 (GMSC)

• 批准号: 10673899
• 负责人: Carlos Cruchaga
• 金额: $ 71.63万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10673899
• 关键词: Adult; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease risk; Alzheimer’s disease biomarker; Amyloid beta-Protein; Basic Science; Behavior; Bilirubin; Biocompatible Materials; Bioinformatics; Biological; Biological Markers; Biological databases; Biology; Blood; Blood specimen; Brain; Cholesterol; Clinical Chemistry; Clinical Sciences; Clinical assessments; Cognition; Cognitive; Collaborations; Collection; Complex; Creatinine; DNA; DNA Library; DNA Methylation; Data; Data Analyses; Data Collection; Databases; Dementia; Deposition; Developed Countries; Disease; Elderly; Face; Genes; Genetic; Genetic study; Genomics; Genotype; Glial Fibrillary Acidic Protein; Goals; Hormones; Human; Image; Impaired cognition; Individual; Inflammation; Inflammatory; Investigation; Life Style; Light; Liver; Longitudinal Studies; Measurement; Measures; Metabolic; Molecular Disease; Multiomic Data; Nerve Degeneration; Neurodegenerative Disorders; Participant; Perimenopause; Phenotype; Plasma; Population; Procedures; Process; Proteins; Proteomics; Protocols documentation; Psychometrics; Qualifying; Quality Control; RNA; Renal function; Research Personnel; Sampling; Site; Specimen; Standardization; Testing; Time; Tube; Universities; Visit; Washington; aging brain; allostatic load; biobank; biomarker discovery; connectome; data acquisition; data integration; epigenomics; genetic information; genetic variant; genome wide association study; healthy aging; inflammatory marker; lipidomics; medical schools; meetings; metabolomics; molecular marker; mullerian-inhibiting hormone; multiple omics; neurofilament; neuroimaging; neuroinflammation; novel; novel marker; polygenic risk score; recruit; resilience; risk prediction model; statistics; tau-1; transcriptomics

ABSTRACT FOR GMSC Aging populations worldwide, particularly in developed countries, face an increasing burden of neurodegenerative diseases. Genetic studies have greatly contributed to our understanding of these complex diseases. Now it is clear that studies beyond genetics, such as transcriptomics, proteomics, or epigenomics are needed to fully understand the biology of neurodegeneration and healthy aging, to identify novel biomarkers and identify novel targets. The goal of the Genomics and Multi-omics Specimens core (GMSC) is to obtain, bank and quality control (QC) biospecimens (DNA, RNA and plasma) from AABC participants. The core will generate GWAS, APOE and polygenic risk scores for all participants that will be used by other AABC Projects. We will also generate longitudinal multi-omic (classic blood analytes, anti-Müllerian hormone (AMH), Alzheimer disease (AD) biomarkers, and neuroinflammation proteomics) blood data that will be used for Projects 1-4 to determine biomarker positivity for AD, allosteric load, inflammation, lifestyle behaviors, and the menopausal transition that are instrumental for those projects.

GMSC 摘要 全球人口老龄化，特别是发达国家，面临着日益沉重的负担 神经退行性疾病极大地促进了我们对这些复合物的理解。 现在很明显，除了遗传学之外的研究，例如转录组学、蛋白质组学或表观基因组学， 需要充分了解神经退行性变和健康衰老的生物学，以确定新的生物标志物和 基因组学和多组学样本核心 (GMSC) 的目标是获取、储存和确定新靶标。 核心将生成来自 AABC 参与者的质量控制 (QC) 生物样本（DNA、RNA 和血浆）。 所有参与者的 GWAS、APOE 和多基因风险评分将被其他 AABC 项目使用。 还生成纵向多组学（经典血液分析物、抗苗勒氏管激素 (AMH)、阿尔茨海默病 （AD）生物标志物和神经炎症蛋白质组学）血液数据将用于项目 1-4 以确定 AD、变构负荷、炎症、生活方式行为和更年期过渡的生物标志物呈阳性 对这些项目很有帮助。