Guideline-directed management and therapy (GDMT) for the prevention of postpartum cardiac dysfunction in preeclamptic African American women

预防先兆子痫非裔美国女性产后心功能不全的指南指导管理和治疗 (GDMT)

• 批准号: 10675331
• 负责人: Sajid Shahul
• 金额: $ 34.36万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-01-01 至 2025-12-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10675331
• 关键词: Address; African American; Aspirin; Blood Pressure; Cardiac development; Cardiovascular Diseases; Cardiovascular Pregnancy Complications; Cessation of life; Clinical; Clinical Trials; Data; Deterioration; Development; EFRAC; Early Diagnosis; Evaluation; Functional disorder; Goals; Guidelines; Heart; Heart Rate; Heart failure; Hypertension; Incidence; Interdisciplinary Study; Intervention; Knowledge; Lead; Learning; Left; Life; Measures; Mediation; Medical; Methodology; Monitor; Morbidity - disease rate; Mothers; Myocardial dysfunction; Organ; Parents; Patients; Postpartum Hypertension; Postpartum Period; Pre-Eclampsia; Pregnancy; Pregnant Women; Prevention therapy; Pulmonary Edema; Race; Randomized; Randomized Controlled Trials; Recording of previous events; Stroke; Testing; Time; Ventricular Function; Visit; Woman; activin A; antenatal; blood pressure control; blood pressure elevation; blood pressure reduction; cardiogenesis; clinically relevant; cohort; compare effectiveness; epidemiology study; heart function; hypertensive; hypertensive heart disease; improved; innovation; mortality; pregnant; prevent; racial and ethnic; randomized trial

Project Summary/Abstract African American women are 60% more likely to have postpartum hypertension and are nearly three times more likely to die from preeclampsia than white women. Both during pregnancy and overall, hypertension in African American women is more severe and presents earlier in life. In addition, compared to other ethnic- racial groups, African American women have higher mortality rates from hypertension-related end-organ damage like heart failure and stroke. Currently, however, no proven interventions exist to prevent or mitigate the development of hypertensive heart disease during the postpartum period. Using a randomized mechanistic clinical trial of guideline-directed medical therapy for postpartum African American women with preeclampsia, we will advance knowledge of cardiac dysfunction in preeclampsia and its possible treatments. We pursue a specific aim to answer these questions. AIM 1 is a randomized trial to test whether guideline-directed medical therapy improves cardiac function and decreases blood pressure in postpartum African American women with preeclampsia. This project innovates methodologically to dramatically advance our understanding of a significant cause of morbidity and mortality in African American women.

项目概要/摘要 非裔美国女性患产后高血压的可能性高出 60%，几乎是女性的三倍 比白人女性更有可能死于先兆子痫。无论是在怀孕期间还是总体上，高血压 非裔美国女性的病情更为严重，且发病时间更早。另外，与其他种族相比—— 种族群体中，非裔美国女性因高血压相关终末器官死亡率较高 心力衰竭和中风等损害。然而，目前尚无行之有效的干预措施可以预防或减轻 产后高血压心脏病的发展。 使用指南指导的非洲产后药物治疗的随机机制临床试验 患有先兆子痫的美国女性，我们将增进对先兆子痫及其心脏功能障碍的了解 可能的治疗方法。我们追求一个特定的目标来回答这些问题。 AIM 1 是一项随机试验来测试 指南指导的药物治疗是否可以改善心脏功能并降低血压 产后患有先兆子痫的非洲裔美国妇女。该项目在方法上进行了创新 极大地增进了我们对非裔美国人发病和死亡的重要原因的理解 女性。