Centrifugal Modulation of Visual Sensitivity

视觉灵敏度的离心调制

• 批准号: 7895523
• 负责人: LEI LI
• 金额: $ 37.5万
• 依托单位: UNIVERSITY OF NOTRE DAME
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7895523
• 关键词: Amphibia; Biological; Birds; Brain; Cells; Development; Dopamine; Fishes; Foundations; Genes; Genetic; Genetic Models; Goals; Homologous Gene; Human; Light; Mammals; Modeling; Mutation; Nerve; Nerve Fibers; Neurons; Neurophysiology - biologic function; Neurotransmitters; Pathway interactions; Physiological; Play; Property; Reptiles; Research; Retina; Retinal; Role; Signal Transduction; Synapses; Testing; Vertebrates; Vision; Visual; Visual Pathways; Visual system structure; Zebrafish; olfactory bulb; research study

The goal of the proposed research is to understand the roles of centrifugal input in vertebrate retinas. In all vertebrates (include humans), the retinas receive centrifugal input from the brain. In fish, the centrifugal input originates from the terminalis nerve (TN) in the olfactory bulb. In the retina, the TN fibers synapse onto dopaminergic interplexiform cells (DA-IPCs). The proposed research will investigate the biological roles of the centrifugal pathway in visual system functions. Specifically, we will determine the physiological properties of the TN cells, the effects of centrifugal input in vision, and the genetic mechanisms of the development of the centrifugal pathway. The results from the proposed research will shed light on the mechanisms of centrifugal modulation of visual sensitivity.

拟议的研究的目的是了解离心输入在脊椎动物视网膜中的作用。在所有脊椎动物（包括人类）中，视网膜从大脑接收离心输入。在鱼类中，离心输入起源于嗅球中的末端神经（TN）。在视网膜中，TN纤维突触到多巴胺能跨性别细胞（DA-IPC）。拟议的研究将研究离心系统在视觉系统函数中的生物学作用。具体而言，我们将确定TN细胞的生理特性，视觉中离心输入的影响以及离心途径发展的遗传机制。拟议研究的结果将阐明视觉灵敏度的离心调节机制。

项目成果

Sensory Integration: Cross-Modal Communication Between the Olfactory and Visual Systems in Zebrafish.

• DOI: 10.1093/chemse/bjz022
• 发表时间: 2019-04
• 期刊: Chemical senses
• 影响因子: 3.5
• 作者: Lei Li

Characterization of voltage-activated ionic currents in the GnRH-containing terminalis nerve in transgenic zebrafish.

转基因斑马鱼含 GnRH 终末神经电压激活离子电流的表征。

• DOI: 10.1016/j.brainres.2010.10.024
• 发表时间: 2011
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Huang,Luoxiu;Li,Lei
• 通讯作者: Li,Lei

Phosphoinositide kinases play key roles in norepinephrine- and angiotensin II-induced increase in phosphatidylinositol 4,5-bisphosphate and modulation of cardiac function.

磷酸肌醇激酶在去甲肾上腺素和血管紧张素 II 诱导的磷脂酰肌醇 4,5-二磷酸增加和心脏功能调节中发挥关键作用。

• DOI: 10.1074/jbc.m113.527952
• 发表时间: 2014
• 期刊: The Journal of biological chemistry
• 作者: Xu,Jia-Xi;Si,Man;Zhang,Hui-Ran;Chen,Xing-Juan;Zhang,Xi-Dong;Wang,Chuan;Du,Xiao-Na;Zhang,Hai-Lin
• 通讯作者: Zhang,Hai-Lin

Characterization of the human oncogene SCL/TAL1 interrupting locus (Stil) mediated Sonic hedgehog (Shh) signaling transduction in proliferating mammalian dopaminergic neurons.

• DOI: 10.1016/j.bbrc.2014.05.048
• 发表时间: 2014-07
• 期刊: Biochemical and biophysical research communications
• 影响因子: 3.1
• 作者: Lei Sun;A. Carr;Pingjing Li;Jessica Lee;Mary McGregor;Lei Li

Pineal photoreceptor cells are required for maintaining the circadian rhythms of behavioral visual sensitivity in zebrafish.

松果体感光细胞是维持斑马鱼行为视觉敏感性的昼夜节律所必需的

• DOI: 10.1371/journal.pone.0040508
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Li X;Montgomery J;Cheng W;Noh JH;Hyde DR;Li L
• 通讯作者: Li L