Stem Cells in the Retina

视网膜干细胞

• 批准号: 7813830
• 负责人: THOMAS A REH
• 金额: $ 36.93万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-07 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7813830
• 关键词: Address; Adopted; Adult; Amphibia; Astrocytes; Birds; Brain; Cell Cycle; Cell Proliferation; Cells; Central Nervous System Part; Chromatin Remodeling Factor; Data; Degenerative Disorder; Development; Family; Fishes; Gene Expression; Genes; Glial Differentiation; Growth Factor; Human; Immunohistochemistry; In Situ Hybridization; In Vitro; Lead; Mediating; Microarray Analysis; Modeling; Molecular; Mus; Natural regeneration; Neuraxis; Neuroglia; Neurons; Phenotype; Phosphorylation; Process; Proteins; Rana; Rattus; Research Personnel; Rest; Retina; Retinal; Role; Series; Signaling Molecule; Source; Stem cells; Testing; Time; Transforming Growth Factor beta; Transgenic Mice; Up-Regulation; Vertebrates; base; cell type; chromatin remodeling; glial cell development; hatching; helix-loop-helix protein differentiation inhibitor; histogenesis; homeodomain; human FRAP1 protein; in vivo; member; nestin protein; neurogenesis; neurotoxic; postnatal; prevent; progenitor; programs; repaired; research study; response; retinal damage; retinal progenitor cell; retinal regeneration; transcription factor; Address; Adopted; Adult; Amphibia; Astrocytes; Birds; Brain; Cell Cycle; Cell Proliferation; Cells; Central Nervous System Part; Chromatin Remodeling Factor; Data; Degenerative Disorder; Development; Family; Fishes; Gene Expression; Genes; Glial Differentiation; Growth Factor; Human; Immunohistochemistry; In Situ Hybridization; In Vitro; Lead; Mediating; Microarray Analysis; Modeling; Molecular; Mus; Natural regeneration; Neuraxis; Neuroglia; Neurons; Phenotype; Phosphorylation; Process; Proteins; Rana; Rattus; Research Personnel; Rest; Retina; Retinal; Role; Series; Signaling Molecule; Source; Stem cells; Testing; Time; Transforming Growth Factor beta; Transgenic Mice; Up-Regulation; Vertebrates; base; cell type; chromatin remodeling; glial cell development; hatching; helix-loop-helix protein differentiation inhibitor; histogenesis; homeodomain; human FRAP1 protein; in vivo; member; nestin protein; neurogenesis; neurotoxic; postnatal; prevent; progenitor; programs; repaired; research study; response; retinal damage; retinal progenitor cell; retinal regeneration; transcription factor

DESCRIPTION (provided by applicant): The central nervous system (CNS) of people has only a limited capacity to regenerate after traumatic damage or degenerative diseases. However, in the past few years several lines of evidence have shown that new neurons are generated in the brains of higher vertebrates, and even humans. While the amount of neurogenesis that occurs in adults is limited, the capacity for stimulating this process for repair and regeneration is just beginning to be explored. We have found that the retina of the post hatch chick is capable of a limited amount of regeneration. In the past year we have also discovered a similar process in the rat and mouse retina. In this proposal we outline experiments that will lead to a better understanding of the molecular factors that regulate glial proliferation, and the mechanisms by which they maintain their phenotype. We also will attempt to define the basis for their plasticity and ability to serve as retinal progenitors and as a substrate for retinal regeneration. We use the retina, an easily accessible part of the central nervous system, as a model for the rest of the CNS.

描述（由申请人提供）：人的中枢神经系统（CNS）在创伤或退行性疾病后的再生能力有限。但是，在过去的几年中，有几条证据表明，高脊椎动物甚至人类的大脑中产生了新的神经元。尽管成人发生的神经发生量受到限制，但刺激修复和再生过程的能力才刚刚开始探索。我们发现，孵化后小鸡的视网膜能够有限的再生。在过去的一年中，我们还发现了大鼠和小鼠视网膜的类似过程。在此提案中，我们概述了实验，这些实验将可以更好地理解调节神经胶质增殖的分子因子以及维持其表型的机制。我们还将尝试定义其可塑性和作为视网膜祖细胞和视网膜再生的底物的能力的基础。我们使用视网膜，这是中枢神经系统的易于访问的部分，作为CNS其余部分的模型。