Collaborative Pediatric Critical Care Research Network - Clinical Site

儿科重症监护协作研究网络 - 临床网站

基本信息

批准号：
10670251
负责人：
PETER M MOURANI
金额：
$ 7.22万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-08-13 至 2026-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10670251
关键词：
Acute Acute Lung Injury Acute Renal Failure with Renal Papillary Necrosis Address Admission activity Area Arkansas Award Basic Science Blood Vessels Cardiopulmonary Cardiovascular Diseases Caring Catchment Area Child Child Development Child Health Childhood Childhood Injury Clinical Clinical Research Clinical Sciences Clinical Trials Clinical and Translational Science Awards Collaborations Colorado Complement Activation Contracts Critical Care Critical Illness Critically ill children Data Data Coordinating Center Development Discipline Disease Ensure Ethnic Origin Evaluation Faculty Family Functional disorder Funding Geography Goals Good Clinical Practice Hospitalization Immune response Institution Investigation Knowledge Laboratories Leadership Link Location Longitudinal Studies Lower Respiratory Tract Infection Lung Lung diseases Medicine Mentored Clinical Scientist Development Program Mentors Metadata Mission Mississippi Molecular Multiple Organ Failure National Heart, Lung, and Blood Institute Organ Outcome Outpatients Participant Pathogenesis Patients Pediatric Acute Lung Injury Pediatric Acute Respiratory Distress Syndrome Pediatric Hospitals Performance Physicians Population Population Heterogeneity Principal Investigator Procedures Process Program Development Protocols documentation Publications Race Recording of previous events Rehabilitation therapy Research Research Design Research Institute Research Personnel Research Priority Research Training Resources Respiratory Failure Role Rural Scientific Advances and Accomplishments Scientist Sepsis Series Site Talents Technology Therapeutic Training Training Programs Translational Research Translational trial Translations Traumatic Brain Injury United States National Institutes of Health Universities Work alveolar epithelium carbohydrate metabolism career development clinical research site clinical translation cohort effective therapy expectation experience follow-up immunoregulation improved outcome innovation medically underserved meetings member multidisciplinary next generation outreach program participant enrollment pathogen patient population pediatric department programs pulmonary vascular disorder respiratory microbiome severe injury socioeconomics success underserved community

项目摘要

ABSTRACT – University of Colorado Denver With our participation in this iteration of the Collaborative Pediatric Critical Care Research Network (CPCCRN), we contributed to a series of discoveries that enhanced our understanding of disease processes and resulted in a multitude of potentially effective treatments for critically ill and injured children that require definitive evaluation in clinical trials. There continues to be tremendous need for a collaborative research network in pediatric critical care to facilitate the swift and effective translation of scientific and technologic discoveries into clinical advances. Access to appropriate patients and expertise in the execution of clinical trials must be linked to scientists and laboratories working within and across disciplines at the cutting edge of scientific advancement. At the University of Colorado Denver (UCD) and Children’s Hospital Colorado (CHCO), we have a long history of successful collaborative basic, translational, and clinical science programs focused on pediatric critical illness and injury. We will provide several unique areas of strength to the CPCCRN, including: 1) a distinctive multidisciplinary team of collaborative researchers with specific expertise in mechanistic investigations of cardiovascular and pulmonary diseases, 2) a proven and successful track record as a clinical site in CPCCRN, 3) expertise with pediatric clinical trials execution, including innovative programs to enhance positive research culture among clinical staff and participation among patients and families, 4) a 7-state catchment area with high volumes of critically ill and injured children, 5) an in-house rehabilitation program and extensive outpatient outreach program capable of providing follow-up care to nearly all our critically ill patients, and 6) a dynamic partnership with the Children’s Hospital Colorado Research Institute and Colorado Clinical Translational Science Institute to provide extensive research resources. Our ancillary site, Arkansas Children’s Hospital (ACH) provides 1) experience with pediatric clinical trials execution, including previous successful membership in CPCCRN 2) provision of care to nearly all of the critically ill children from the State of Arkansas and a 4-state catchment area, 3) representation of an Institutional Development Award (IDeA) state (historically received low levels of NIH support) and involving their unique populations (rural, Marshallese, and medically underserved communities) in the NIH mission, and 4) a rich partnership with the ACH Research Institute and University of Arkansas Clinical Translational Science Award to provide comprehensive research resources. Utilizing these assets, we will augment the contributions of CPCCRN to the care of critically ill children through rigorous clinical trial execution, innovative translational and clinical trial proposals, participation in CPCCRN leadership committees, and training the next generation of pediatric critical care researchers. The proposed trial of “Personalized Immunomodulation in Sepsis induced Multiple Organ Dysfunction Syndrome” is an incredibly innovative approach that moves beyond a “one therapy for all” paradigm to an individualized therapeutic approach that will dramatically improve outcomes for children with sepsis. We are enthusiastic and committed to participate in this project with the new 24-site CPCCRN.

摘要——科罗拉多大学丹佛分校随着我们参与儿科重症监护协作研究网络 (CPCCRN) 的这一迭代，我们做出了一系列发现，增强了我们对疾病过程的理解，并导致对于需要明确评估的危重和受伤儿童有多种潜在有效的治疗方法临床试验中仍然非常需要儿科危重病的合作研究网络。致力于促进科学技术发现迅速有效地转化为临床进展。获得适当的患者和执行临床试验的专业知识必须与科学家和大学内和跨学科的实验室处于科学进步的前沿。科罗拉多州丹佛市 (UCD) 和科罗拉多州儿童医院 (CHCO) 拥有悠久的成功历史重点关注儿科危重疾病和损伤的合作基础、转化和临床科学项目。我们将为 CPCCRN 提供几个独特的优势领域，包括：1）独特的多学科团队具有心血管和心血管疾病机制研究特定专业知识的合作研究人员肺部疾病，2) 作为 CPCCRN 临床中心的经过验证和成功的记录，3) 专业知识儿科临床试验的执行，包括增强积极研究文化的创新计划临床工作人员以及患者和家属的参与，4) 一个由 7 个州组成的集水区，拥有大量的重病和受伤儿童，5) 内部康复计划和广泛的门诊外展计划能够为几乎所有危重患者提供后续护理，并且 6) 与科罗拉多儿童医院研究所和科罗拉多临床转化科学研究所提供我们的辅助站点阿肯色州儿童医院 (ACH) 提供 1) 经验。执行儿科临床试验，包括之前成功成为 CPCCRN 会员 2) 提供护理来自阿肯色州和 4 个州辖区的几乎所有危重儿童，3) 代表获得机构发展奖 (IDeA) 州（历来获得较低水平的 NIH 支持）并涉及 NIH 任务中的独特人群（农村、马绍尔人和医疗服务不足的社区），以及 4) 与ACH研究所和阿肯色大学临床转化科学学院有着丰富的合作伙伴关系奖励提供全面的研究资源，我们将加大贡献。 CPCCRN 通过严格的临床试验执行、创新的转化技术来护理危重儿童和临床试验提案、参与 CPCCRN 领导委员会以及培训下一代儿科重症监护研究人员提出的“败血症诱导的个性化免疫调节”试验多器官功能障碍综合症”是一种令人难以置信的创新方法，超越了“单一疗法” 为所有人”的个体化治疗方法范例，将显着改善儿童的治疗结果我们热衷并致力于通过新的 24 个站点 CPCCRN 参与这个项目。