CALIFORNIA NEUROAIDS TISSUE NETWORK (AIDS)

加州神经艾滋病组织网络（艾滋病）

• 批准号: 7603906
• 负责人: ROBERT A LARSEN
• 金额: $ 24.07万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603906
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Autopsy; Brain; California; Cessation of life; Clinic; Clinical; Computer Retrieval of Information on Scientific Projects Database; County Hospitals; Data; Enrollment; Family; Funding; Grant; Hospitals; Hour; Institution; Life Expectancy; Medical; Monitor; Neurologic; Neurologist; Neuropsychology; Participant; Pathology; Patients; Performance; Principal Investigator; Procedures; Quality Control; Recruitment Activity; Research; Research Personnel; Research Subjects; Resources; Site; Source; Specimen; Structure; Tissue Sample; Tissues; Training; Trauma; United States National Institutes of Health; anticancer research; case control; cohort; data management; design; follow-up; repository

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The USC component of the CNTN is designed to identify, recruit, enroll, and assess a cohort of 70 AIDS patients with life expectancies of less than one year of whom about 12 will be autopsied each year. Tissue samples will be obtained from 12-15 control cases dying after non-neurologic trauma will be sent to the tissue repository bank over 5 years. The principal investigator and a neurologist will perform the clinical procedures required of the project and oversee a research assistant who will perform the neuropsychocologic assessments. A neuropathologist and pathology assistant (deanor) will conduct the neurologic autopsy and assist in the performance of the general autopsy when permitted by the family. The USC investigators will transmit data and specimens to the CNTN Administrative and Data Center and Brain Bank at USCD, which will provide data management, tissue storage, coordination among network sites, and quality control of all aspects of the project through training and monitoring. Recruitment of participants will will be focused at the LAC+USC Rand Schrader HIV?AIDS Clinic which follows an estimated 2,650 AIDS Patients. Research Subjects will be replaced as they die or are lost to follow up. These patients will undergo structured Medical, neurologic, neuropsychologic, immunocologic, and virologic assessments every six months until they die. Postmortem will be conducted at the LA County Hospital if the subject dies within that facility or they will be transferred to the Norris Cancer Research Hospital. All post mortem examinations will be conducted within 12 hours of death.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 CNTN的USC组成部分旨在识别，招募，注册和评估70名艾滋病患者的队列，预期寿命少于一年，其中大约12名将被搬迁。 在5年内，将从非神经创伤后死亡的12-15例对照病例中获得组织样品。 首席研究员和神经科医生将执行该项目所需的临床程序，并监督将进行神经心理学评估的研究助理。 神经病理学家和病理学助理（Deanor）将进行神经系统尸检，并在家庭允许时协助进行一般尸检。 USC调查人员将在USCD的CNTN行政和数据中心和大脑库传输数据和标本，该数据中心将提供数据管理，组织存储，网站之间的协调以及通过培训和监视对项目各个方面的质量控制。 参与者的招募将集中在LAC+USC Rand Schrader HIV？艾滋病诊所，估计有2,650名艾滋病患者。 研究对象将在死亡或失去跟进时更换。 这些患者将每六个月进行一次结构化的医学，神经系统，神经心理学，免疫学和病毒学评估。 验尸将在洛杉矶县医院进行，如果该受试者在该设施内死亡，否则将转移到诺里斯癌症研究院。 所有验尸检查将在死亡后12小时内进行。