PILOT TRIAL CORRELATING METABOLIC PROFILE OF TAMOXIFEN WITH HOT FLASHES

将他莫昔芬代谢特征与潮热相关联的试点试验

• 批准号: 7603707
• 负责人: DANIEL F. HAYES
• 金额: $ 1.29万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603707
• 关键词: Adverse effects; Computer Retrieval of Information on Scientific Projects Database; DNA; Funding; Grant; Hot flushes; Human; Individual; Institution; Menopausal hot flushes; Metabolic; Mutation; Pharmaceutical Preparations; Purpose; Research; Research Personnel; Resources; Source; Tamoxifen; United States National Institutes of Health; Woman; pilot trial

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to try and identify which women who take tamoxifen are likely to suffer from hot flashes, or which are more likely to have other side effects or benefits from the drug. We will determine this by figuring out whether there are mutations that normally occur in human DNA that might influence the way individuals respond to various types of medications.'

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究的目的是尝试确定哪些服用他莫昔芬的女性可能会出现潮热，或者哪些女性更有可能从该药物中产生其他副作用或益处。 我们将通过弄清楚人类 DNA 中是否存在通常发生的突变来确定这一点，这些突变可能会影响个体对各种药物的反应方式。