MECHANISMS OF PAIN IN WOMEN WITH ENDOMETRIOSIS

子宫内膜异位症女性疼痛的机制

• 批准号: 7603837
• 负责人: Sawsan As-Sanie
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603837
• 关键词: Affect; Age; Biochemical; Blood; Brain; Computer Retrieval of Information on Scientific Projects Database; Condition; Frequencies; Funding; Grant; Hormonal; Implant; Inflammation; Institution; Interview; Irritable Bowel Syndrome; Life; Medical; Numbers; Operative Surgical Procedures; Organ; Pain; Pain Disorder; Pharmaceutical Preparations; Process; Purpose; Questionnaires; Research; Research Personnel; Resources; Site; Source; Standards of Weights and Measures; Symptoms; Syndrome; Temporomandibular Joint Disorders; Testing; Tissues; United States National Institutes of Health; Vulvodynia; Woman; chronic pain; chronic pelvic pain; endometriosis; improved; pressure; psychologic; reproductive; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endometriosis is a common ailment estimated to affect 12% of reproductive-aged women and up to 80% of women with chronic pelvic pain. Standard medical and surgical treatments used to treat women with endometriosis are insufficient because many women do not get adequate relief of their pain and pain often returns even if they initially responded to treatment. Despite the high frequency and often negative impact on women's lives, little is known about why and how some, but not all, women with endometriosis develop chronic pelvic pain. A variety of possibilities have been explored with numerous studies failing to find an association between pain symptoms and the extent or spread of the endometriosis implants. Pain in other chronic pain syndromes, such as irritable bowel syndrome, fibromyalgia, temporomandibular disorders, and vulvodynia, has been shown to be related to abnormalities in the way the brain processes and interprets pain, rather than from direct damage or inflammation of specific organs or tissues. A common finding in these pain syndromes is increased tenderness to pressure, even far away from the primary site of pain symptoms. Successful treatment of these chronic pain disorders often includes medications that improve the way the brain processes and interprets pain. Preliminary research in a small number of women with endometriosis and chronic pelvic pain suggests that abnormalities in pain processing may also be a problem in this condition. If such abnormalities are confirmed in women with endometriosis-associated chronic pelvic pain, this could result in a paradigm shift in the treatment of this condition. In addition to therapies aimed at suppressing or excising endometriosis implants (i.e. hormonal medications and/or surgery), some women may also benefit from treatments aimed at correcting abnormalities in pain processing. Thus, the overall purpose of this research study is to better understand the cause of chronic pelvic pain in women with endometriosis. The specific aims of this study are to describe the spectrum of physical, biochemical, and psychological function of women with endometriosis and determine whether an abnormality in pain processing occurs in a subset of women with endometriosis-associated chronic pelvic pain. The study involves a medical interview and examination, filling out several questionnaires, a blood draw, and a brief pain testing session.'

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 子宫内膜异位症是一种常见疾病，估计影响 12% 的育龄女性和高达 80% 患有慢性盆腔疼痛的女性。用于治疗子宫内膜异位症女性的标准药物和手术治疗是不够的，因为许多女性的疼痛没有得到充分缓解，即使最初对治疗有反应，疼痛也经常复发。尽管子宫内膜异位症的发病率很高，而且常常对女性的生活产生负面影响，但人们对为什么一些（但不是全部）患有子宫内膜异位症的女性会出现慢性盆腔疼痛以及如何出现慢性盆腔疼痛知之甚少。大量研究探索了多种可能性，但未能发现疼痛症状与子宫内膜异位症种植体的范围或扩散之间的关联。 其他慢性疼痛综合征中的疼痛，如肠易激综合征、纤维肌痛、颞下颌关节紊乱和外阴痛，已被证明与大脑处理和解释疼痛的方式异常有关，而不是由于特定器官或器官的直接损伤或炎症所致。组织。这些疼痛综合征的一个常见发现是对压力的压痛增加，甚至远离疼痛症状的主要部位。这些慢性疼痛疾病的成功治疗通常包括改善大脑处理和解释疼痛方式的药物。对少数患有子宫内膜异位症和慢性盆腔疼痛的女性进行的初步研究表明，疼痛处理异常也可能是这种情况的一个问题。如果在患有子宫内膜异位症相关慢性盆腔疼痛的女性中证实这种异常，可能会导致这种疾病治疗的范式转变。除了旨在抑制或切除子宫内膜异位植入物的治疗（即激素药物和/或手术）之外，一些女性还可能受益于旨在纠正疼痛处理异常的治疗。因此，这项研究的总体目的是更好地了解子宫内膜异位症女性慢性盆腔疼痛的原因。本研究的具体目的是描述患有子宫内膜异位症的女性的生理、生化和心理功能范围，并确定患有子宫内膜异位症相关慢性盆腔疼痛的女性子集是否出现疼痛处理异常。该研究包括医疗访谈和检查、填写几份调查问卷、抽血和简短的疼痛测试。