MECHANISMS OF PAIN IN WOMEN WITH ENDOMETRIOSIS

子宫内膜异位症女性疼痛的机制

• 批准号: 7603837
• 负责人: Sawsan As-Sanie
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603837
• 关键词: Affect; Age; Biochemical; Blood; Brain; Computer Retrieval of Information on Scientific Projects Database; Condition; Frequencies; Funding; Grant; Hormonal; Implant; Inflammation; Institution; Interview; Irritable Bowel Syndrome; Life; Medical; Numbers; Operative Surgical Procedures; Organ; Pain; Pain Disorder; Pharmaceutical Preparations; Process; Purpose; Questionnaires; Research; Research Personnel; Resources; Site; Source; Standards of Weights and Measures; Symptoms; Syndrome; Temporomandibular Joint Disorders; Testing; Tissues; United States National Institutes of Health; Vulvodynia; Woman; chronic pain; chronic pelvic pain; endometriosis; improved; pressure; psychologic; reproductive; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Endometriosis is a common ailment estimated to affect 12% of reproductive-aged women and up to 80% of women with chronic pelvic pain. Standard medical and surgical treatments used to treat women with endometriosis are insufficient because many women do not get adequate relief of their pain and pain often returns even if they initially responded to treatment. Despite the high frequency and often negative impact on women's lives, little is known about why and how some, but not all, women with endometriosis develop chronic pelvic pain. A variety of possibilities have been explored with numerous studies failing to find an association between pain symptoms and the extent or spread of the endometriosis implants. Pain in other chronic pain syndromes, such as irritable bowel syndrome, fibromyalgia, temporomandibular disorders, and vulvodynia, has been shown to be related to abnormalities in the way the brain processes and interprets pain, rather than from direct damage or inflammation of specific organs or tissues. A common finding in these pain syndromes is increased tenderness to pressure, even far away from the primary site of pain symptoms. Successful treatment of these chronic pain disorders often includes medications that improve the way the brain processes and interprets pain. Preliminary research in a small number of women with endometriosis and chronic pelvic pain suggests that abnormalities in pain processing may also be a problem in this condition. If such abnormalities are confirmed in women with endometriosis-associated chronic pelvic pain, this could result in a paradigm shift in the treatment of this condition. In addition to therapies aimed at suppressing or excising endometriosis implants (i.e. hormonal medications and/or surgery), some women may also benefit from treatments aimed at correcting abnormalities in pain processing. Thus, the overall purpose of this research study is to better understand the cause of chronic pelvic pain in women with endometriosis. The specific aims of this study are to describe the spectrum of physical, biochemical, and psychological function of women with endometriosis and determine whether an abnormality in pain processing occurs in a subset of women with endometriosis-associated chronic pelvic pain. The study involves a medical interview and examination, filling out several questionnaires, a blood draw, and a brief pain testing session.'

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 子宫内膜异位症是一种常见的疾病，估计会影响12％的生殖妇女和多达80％的慢性骨盆疼痛女性。用于治疗子宫内膜异位症女性的标准医学和外科手术治疗不足，因为许多女性最初对治疗有反应，也经常会恢复疼痛和疼痛。尽管频率很高，而且经常对妇女的生活产生负面影响，但对某些（但不是全部）子宫内膜异位症的女性会导致慢性骨盆疼痛的原因知之甚少。已经探索了多种可能性，许多研究未能发现疼痛症状与子宫内膜异位症植入物的程度或扩散之间的关联。 其他慢性疼痛综合征的疼痛，例如肠易激综合征，纤维肌痛，颞下颌疾病和外阴痛，已被证明与大脑过程和解释疼痛的方式有关，而不是与特定器官或组织的直接损害或炎症有关。这些疼痛综合症中的一个普遍发现是增加压力的压力，甚至远离疼痛症状的主要部位。这些慢性疼痛障碍的成功治疗通常包括改善大脑过程和解释疼痛方式的药物。对少数子宫内膜异位和慢性骨盆疼痛的少数女性进行初步研究表明，在这种情况下，疼痛处理异常也可能是一个问题。如果与子宫内膜异位症相关的慢性骨盆疼痛的女性确认这种异常，这可能会导致这种疾病治疗的范式转移。除了旨在抑制或切除子宫内膜异位症植入物（即激素药物和/或手术）的疗法外，一些妇女还可能受益于旨在纠正疼痛处理异常的治疗方法。因此，这项研究的总体目的是更好地了解子宫内膜异位症女性慢性骨盆疼痛的原因。这项研究的具体目的是描述子宫内膜异位症女性的物理，生化和心理功能的范围，并确定疼痛处理异常是否发生在与子宫内膜异位症相关的慢性骨盆疼痛的一部分中。该研究涉及医学访谈和检查，填写了几项问卷，抽血和简短的疼痛测试。