NEURODEVELOPMENT AMONG INFANTS WITH DEFORMATIONAL PLAGIOCEPHALY

斜头畸形婴儿的神经发育

• 批准号: 7603573
• 负责人: MATTHEW Louis SPELTZ
• 金额: $ 1.2万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603573
• 关键词: Academy; Age; American; Awareness; Back to Sleep; Brain; Cephalic; Child; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Development; Event; Funding; Grant; Helmet; Image; Infant; Institution; Investigation; Magnetic Resonance Imaging; Medical; Molds; Operative Surgical Procedures; Parents; Pediatrics; Positioning Attribute; Rate; Recruitment Activity; Research; Research Personnel; Resources; Sleep; Source; Subgroup; United States National Institutes of Health; craniofacial; cranium; neurodevelopment; neuropathology; plagiocephaly

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Deformational plagiocephaly (DP) refers to cranial asymmetry believed to be attributable to external forces molding the malleable infant skull. Suspected causal factors include pre-natal factors (e.g., intrauterine constraint), post-natal events (e.g., invariant positioning during sleep) and/or underlying neuropathology. Initial studies of the neurodevelopment of children with DP have found evidence for significant deficits, but methodological problems limit the interpretation of these studies; potential explanations for such findings are unclear. Further investigation is necessary to refine etiological hypotheses and to provide clinicians and parents with accurate information regarding the neurodevelopmental correlates of DP. Several factors indicate the need for rather immediate study of these issues: the rapidly increasing rate of DP (and/or increasing awareness of and parental worry about the condition), the proliferation of associated medical treatments (helmets and craniofacial surgery), the possibility of preventable developmental problems, and the implication of causal association with the American Academy of Pediatrics "Back to Sleep" campaign. In this 5-year, longitudinal, single-center study, we will investigate these issues by recruiting 250 infants with DP and 275 matched controls, following them from age 6 to 36 months. A subgroup of DP cases will be imaged using MRI (n= 46) and compared to controls by sharing data with another NIH-funded study of normal brain development.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 变形型损伤（DP）是指被认为归因于塑造可延展的婴儿头骨的外力的颅不对称。怀疑的因果因素包括产前因素（例如，宫内约束），产后事件（例如，睡眠期间的不变定位）和/或潜在的神经病理学。 DP儿童神经发育的初步研究发现了明显缺陷的证据，但是方法论问题限制了这些研究的解释。这些发现的潜在解释尚不清楚。需要进一步研究以完善病因学假设，并为临床医生和父母提供有关DP神经发育相关性的准确信息。几个因素表明需要立即研究这些问题：DP的速度迅速增加（和/或对父母对疾病的认识和父母的担忧），相关药物治疗的繁殖（头盔和颅面手术）的繁殖，可能预防与美国佩德迪亚的Causal Access of American Access of Pediatemy segale tackips campaign overaight overady''在这项为期5年的纵向单中心研究中，我们将通过招募250名具有DP和275个匹配对照的婴儿来调查这些问题，此后6个月至36个月。 DP病例的亚组将使用MRI（n = 46）成像，并通过与NIH资助的另一项对正常脑发育的研究共享数据，并将其与对照组进行比较。