HERPES VIRUS SURVEILLANCE IN PEDIATRIC SOLID ORGAN TRANSPLANT RECIPIENTS

儿科实体器官移植受者的疱疹病毒监测

• 批准号: 7603518
• 负责人: Jodi M Smith
• 金额: $ 0.04万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603518
• 关键词: Childhood; Chronic rejection of renal transplant; Complication; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Future; Grant; Herpesviridae; Hospitalization; Immunity; Immunosuppressive Agents; Incidence; Infection; Institution; Intervention; Medical Surveillance; New Agents; Organ Transplantation; Prospective Studies; Quality of life; Rate; Research; Research Personnel; Resources; Risk; Role; Sirolimus; Solid; Source; T-Lymphocyte; Testing; Therapeutic; Therapeutic immunosuppression; Transplant Recipients; Transplantation; United States National Institutes of Health; Viral; Virus Diseases; improved; kidney allograft; mycophenolate mofetil; peripheral blood; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Viral infections are an important complication of transplantation. Immunosuppressive therapy interferes with T cell immunity resulting in a high incidence of viral infection. Newer agents, such as mycophenolate mofetil (MMF) and sirolimus, have been associated with an increased risk of herpes virus infection. The introduction of these more potent immunosuppressive agents over the past decade correlates with an increase in the rate of hospitalizations of transplant patients with infections. This prospective study will determine the role of subclinical herpes virus infections in the development of complications such as chronic allograft nephropathy (CAN) and PTLD. By focusing on treatable herpes virus infections, these studies have the potential to identify therapeutic strategies that can be used to diminish the burden of graft loss from CAN, significantly improving renal allograft survival and quality of life in transplant patients. Future specific interventions to test the hypothesis of a direct causal relationship between subclinical herpes virus infection and CAN may include the use of anti-viral therapy in response to subclinical infection of the renal allograft and / or peripheral blood.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 病毒感染是移植的重要并发症。 免疫抑制治疗会干扰T细胞免疫，导致病毒感染的高发病率。 较新的药物，例如霉酚酸酯（MMF）和Sirolimus，与疱疹病毒感染的风险增加有关。 在过去的十年中，引入这些更有效的免疫抑制剂与移植患者感染患者的住院率增加有关。 这项前瞻性研究将确定亚临床疱疹病毒感染在诸如慢性同种异体肾病（CAN）和PTLD等并发症发展中的作用。 通过专注于可治疗的疱疹病毒感染，这些研究具有鉴定可用于减轻CAN的移植物损失负担的治疗策略的潜力，从而显着提高了移植患者的肾脏同种异体移植存活率和生活质量。 未来的特定干预措施来检验亚临床疱疹病毒感染之间直接因果关系的假设，并且可能包括使用抗病毒治疗来响应肾脏同种异体移植和 /或外周血的亚临床感染。