CD4+ T CELL IMMUNITY IN MOTHER-CHILD PAIRS INFECTED WITH HEPATITIS C VIRUS

感染丙型肝炎病毒的母子对 CD4 T 细胞免疫

• 批准号: 7603520
• 负责人: KAREN F MURRAY
• 金额: $ 0.07万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603520
• 关键词: Adult; Age-Years; Antigens; Benign; Blood; Blood Circulation; CD4 Positive T Lymphocytes; Cells; Child; Clinic; Clinic Visits; Clinical Data; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Funding; Gastroenterology; Grant; Hepatitis; Hepatitis C; Hepatitis C virus; Immune response; Immunity; Institution; Liver diseases; Mothers; Patients; Population Research; Research; Research Personnel; Resources; Schedule; Source; Testing; Time; United States National Institutes of Health; Virus; Visit; Work; comparison group; cytokine; improved

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that the benign liver disease course in children who acquire HCV infection perinatally may be related to improved CD4+T cell responsiveness to HCV antigens in the these children compared to adults. In addition, we will test the hypothesis that a regulatory cytokine, which promotes the cellular immune response, is elevated in the circulation of children compared with their mothers. Since mother-child pairs are genetically similar and infected by the same HCV strain, the mothers serve as an ideal adult comparison group to the children. The research population will be twenty mother-child pairs who both are infected with Hepatitis C and 10 control mother-child pairs who are not infected. The subjects, infected pairs and controls, will be patients and their mothers who are attending clinic visits in the CHRMC Gastroenterology Clinic and who will be having blood work done as part of these visits. The child subjects must be a t least one year of age and weigh more than 7 kg. Historical clinical data will be collected from the mother-child pairs. The blood first draw will be at the time of their clinic visit in the Gastroenterology clinic and the second draw will be scheduled for three months later. The control pairs will have only one blood draw done at the time of the clinic visit. In both infected and control groups, 30 ml of blood will be drawn from the mothers, 10ml from the children.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们假设，与成年人相比，这些儿童的CD4+T细胞对HCV抗原的CD4+T细胞反应性的提高可能与CD4+T细胞对HCV抗原的反应提高有关。 此外，我们将检验以下假设：与母亲相比，儿童循环中促进细胞免疫反应的调节性细胞因子升高。 由于母子对在遗传上是相似的，并被相同的HCV菌株感染，因此母亲是儿童的理想成人比较组。 研究人群将是二十对母子双子，他们都感染了丙型肝炎和10个未感染的对照母子对。 受试者，受感染的成对和对照组将是在CHRMC胃肠病学诊所参加诊所就诊的患者及其母亲，并将作为这些就诊的一部分进行血液检查。 儿童受试者必须年龄至少一岁，重7公斤以上。 历史临床数据将从母子对收集。第一次抽血将是在他们在胃肠病学诊所进行诊所就诊时，第二次抽奖将安排在三个月后进行。 控制对将在诊所就诊时只能进行一次抽血。 在受感染和对照组中，母亲将从母亲那里抽取30毫升血液，从儿童那里获得10毫升。