TB Research And Mentorship Program (TB RAMP)

结核病研究和指导计划 (TB RAMP)

• 批准号: 10669011
• 负责人: Elizabeth Fair
• 金额: $ 35.1万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-19 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10669011
• 关键词: Acquired Immunodeficiency Syndrome; Address; Africa; Americas; Area; Asia; Award; Basic Science; Biomedical Research; California; Caring; Cause of Death; Clinical; Clinical Research; Collaborations; Communicable Diseases; Communication; Creativeness; Data; Discipline; Discipline of Nursing; Disease; Education; Educational Curriculum; Enrollment; Epidemic; Faculty; Funding; Funding Mechanisms; Funding Opportunities; Genomics; Goals; Grant; HIV; HIV/AIDS; Health Sciences; Immunology; International; Knowledge; Laboratories; Link; Medicine; Mentors; Mentorship; Methodology; Mission; National Institute of Allergy and Infectious Disease; Online Systems; Ownership; Peer Review; Persons; Pharmacy facility; Philippines; Pilot Projects; Policies; Politics; Postdoctoral Fellow; Program Sustainability; Protocols documentation; Public Health; Public Health Schools; Pulmonology; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Project Grants; Resource Allocation; Resources; San Francisco; Scholars Program; Science; Scientist; Site; Strategic Planning; Structure; Systems Biology; Technology; Training; Translational Research; Travel; Tuberculosis; Uganda; United Nations; United States National Institutes of Health; Universities; Vietnam; World Health Organization; career; design; education research; epidemiology study; experience; global health; health economics; implementation science; innovation; interest; medical schools; meetings; programs; public health relevance; research and development; science education; skill acquisition; skills; translational research program

Summary/Abstract: The TB Research And Mentorship Program (TB RAMP) prepares early-stage investigators (post-doctoral fellows, clinical fellows, junior faculty) from University of California, San Francisco (UCSF) and UC Berkeley for successful careers in tuberculosis (TB) research. Through this research education program focused on TB, we promote and catalyze collaborations between existing faculty across disciplines (infectious diseases, pulmonary medicine, experimental medicine, systems biology, genomics, immunology, health economics, pharmacy, nursing, implementation sciences, diplomacy and policy, global health, etc.); attract and cultivate scholars and junior investigators in the TB field; and strengthen TB research expertise regionally and globally. TB RAMP leverages the extensive NIH-funded training resources at UCSF to have a significant and lasting impact on the conduct of global TB research, as well as on innovations in TB discovery, care and control. Specific Aim 1: The TB Science Intensive. A two-week TB Science Intensive (TBSI) curriculum will be developed and delivered annually to TB RAMP scholars to provide the core concepts and methodologies of TB research and includes skill building in TB RAMP scholars’ own interests and research methods area. The TBSI is enhanced through delivering content expertise to address TB scientific knowledge gaps and to allow TB RAMP scholars to develop their own research protocols for subsequent grants. Specific Aim 2: Research Experiences and Awards Program (REAP). Match scholars with research opportunities through existing transdisciplinary network of research mentors, faculty, and sites, and support innovative research projects linked to peer-reviewed awards. Identified program faculty with extensive research experience and opportunities will be paired with scholars interested in TB research. Research infrastructure at UCSF spans genomics laboratories to state public health departments. Faculty also have collaborations in high burden settings across Asia, Africa, and the Americas that will provide TB RAMP scholars access to data, biospecimens, and opportunities to network with faculty from sites in high-burden settings. Scholars will compete for intramural, peer-reviewed seed funding opportunities. The goal of the REAP is to provide TB research experiences that expand or extend the existing skills of scholars, to provide opportunity for meaningful contribution to research related to the NIAID mission, directly addressing the NIAID Strategic Plan for TB Research. Specific Aim 3: Mentoring Activities. Provide structured, high- quality, sustained mentoring for all scholars enrolled in the program, differentiated into two tracks to provide personalization and specialization; Track 1: Basic and Translational Science and Track 2: Clinical and Operational Science. Creating and nurturing a strong set of mentoring relationships is essential to both core components of TB RAMP, as is developing a rich set of research networks that can support TB RAMP scholars throughout their careers. TB RAMP scholars will have the opportunity for additional mentoring from our international partnered PIs via remote communication.

摘要/摘要： 结核病研究和指导计划 (TB RAMP) 为早期研究人员（博士后）做好准备 加州大学旧金山分校 (UCSF) 和加州大学伯克利分校的研究员、临床研究员、初级教员） 通过这项以结核病为重点的研究教育计划，我们在结核病 (TB) 研究方面取得了成功。 促进和促进现有教师之间的跨学科合作（传染病、肺病 医学、实验医学、系统生物学、基因组学、免疫学、卫生经济学、药学、 护理、实施科学、外交与政策、全球健康等）；吸引和培养学者和 结核病领域的初级研究人员；并加强区域和全球结核病研究专业知识。 利用美国国立卫生研究院 (NIH) 资助的加州大学旧金山分校 (UCSF) 广泛的培训资源，对 开展全球结核病研究，以及结核病发现、护理和控制方面的创新。 具体目标 1： 将开发并提供为期两周的结核病科学强化课程 (TBSI)。 每年向 TB RAMP 学者提供结核病研究的核心概念和方法，包括 TB RAMP 学者自身兴趣和研究方法领域的技能建设通过 TBSI 得到加强。 提供内容专业知识，以解决结核病科学知识差距，并让结核病 RAMP 学者能够发展 他们自己的后续资助的研究方案。具体目标 2：研究经验和奖项。 计划（REAP）。通过现有的跨学科网络为学者提供研究机会。 研究导师、教师和研究中心，并支持与同行评审奖项相关的创新研究项目。 具有丰富研究经验和机会的已确定项目教师将与学者配对 对结核病研究感兴趣的加州大学旧金山分校的研究基础设施涵盖基因组学实验室和公共卫生领域。 各院系还在亚洲、非洲和美洲的高负担环境中开展合作 将为 TB RAMP 学者提供数据、生物样本以及与来自以下国家的教师建立联系的机会 学者们将竞争校内、同行评审的种子资金机会。 REAP 的目标是提供结核病研究经验，以扩展或扩展学者的现有技能， 为与 NIAID 使命相关的研究提供有意义的贡献机会，直接解决 NIAID 结核病研究战略计划的具体目标 3：提供结构化、高水平的指导活动。 为所有参加该项目的学者提供高质量、持续的指导，分为两个轨道，以提供 个性化和专业化；轨道 1：基础和转化科学，轨道 2：临床和 运营科学。创建和培养一套强有力的指导关系对于两个核心都至关重要。 TB RAMP 的组成部分，同时正在开发一套丰富的研究网络来支持 TB RAMP 学者 TB RAMP 学者将有机会获得我们的额外指导 通过远程通信的国际合作 PI。

项目成果

A flexible multi-metric Bayesian framework for decision-making in Phase II multi-arm multi-stage studies.

用于第二阶段多臂多阶段研究决策的灵活多度量贝叶斯框架。

• 发表时间: 2024-02-10
• 影响因子: 2
• 作者: Dufault, Suzanne M;Crook, Angela M;Rolfe, Katie;Phillips, Patrick P J
• 通讯作者: Phillips, Patrick P J

Continuous cough monitoring: a novel digital biomarker for TB diagnosis and treatment response monitoring.

连续咳嗽监测：一种用于结核病诊断和治疗反应监测的新型数字生物标志物。

• 发表时间: 2023-03-01
• 作者: Huddart, S;Asege, L;Jaganath, D;Golla, M;Dang, H;Lovelina, L;Derendinger, B;Andama, A;Christopher, D J;Nhung, N V;Theron, G;Denkinger, C M;Nahid, P;Cattamanchi, A;Yu, C
• 通讯作者: Yu, C

Adherence trajectory as an on-treatment risk indicator among drug-resistant TB patients in the Philippines.

菲律宾耐药结核病患者的依从轨迹作为治疗风险指标。

• 发表时间: 2022
• 影响因子: 3.7
• 作者: Huddart, Sophie;Geocaniga;Crowder, Rebecca;Lim, Alexander Rupert;Lopez, Evanisa;Valdez, Chelsea Lyn;Berger, Christopher A;Destura, Raul;Kato;Cattamanchi, Adithya;Garfin, Anna Marie Celina
• 通讯作者: Garfin, Anna Marie Celina