THE KINETICS OF HIGH MOBILITY GROUP BOX-1 (HMGB1)

高迁移率基团 BOX-1 (HMGB1) 的动力学

• 批准号: 7719271
• 负责人: RICHARD GOLDSTEIN
• 金额: $ 0.28万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719271
• 关键词: Biological Markers; Cardiac; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; HMGB1 Protein; HMGB1 gene; Inflammatory; Institution; Kinetics; Myocardial Ischemia; Outcome; Patients; Research; Research Personnel; Resources; Source; United States National Institutes of Health; cytokine; healthy volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objectives of this study will be explored in the following three specific aims. Specific Aim 1: To examine the correlation between levels of HMGB1 and other inflammatory cytokines, and levels of cardiac biomarkers. Specific Aim 2: To examine the association between levels of HMGB1 and other inflammatory cytokines, and patient outcomes. Specific Aim 3: To examine the correlation between initial levels of HMGB1 in patients with myocardial ischemia and HMGB1 levels in healthy volunteers.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的目标将在以下三个特定目标中探讨。 特定目的1：检查HMGB1水平与其他炎症细胞因子与心脏生物标志物水平之间的相关性。 具体目的2：检查HMGB1水平与其他炎症细胞因子与患者结局之间的关联。 具体目的3：检查健康志愿者的心肌缺血患者和HMGB1水平的HMGB1初始水平之间的相关性。