PHARMACOKINETICS OF ACTIVE TETANUS IMMUNIZATION GIVEN TO HIV INFECTED PATIENTS

HIV 感染者主动破伤风免疫的药代动力学

• 批准号: 7719264
• 负责人: KUMAR ALAGAPPAN
• 金额: $ 26.07万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719264
• 关键词: Antibody Formation; Computer Retrieval of Information on Scientific Projects Database; Diphtheria; Drug Kinetics; Funding; Grant; HIV; Immunization; Institution; Patients; Research; Research Personnel; Resources; Source; Tetanus; United States National Institutes of Health; Vaccination; day; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is seeking to immunize HIV infected patients that are documented to have non-protective titers (0.15 IU/ml) to tetanus. We will then ascertain if these patients are able to mount an antibody response to tetanus immunization. Subjects will be screened and followed for 180 days to determine their level of response to diphtheria tetanus vaccination.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究旨在对经记录对破伤风具有非保护性滴度（0.15 IU/ml）的 HIV 感染患者进行免疫接种。然后我们将确定这些患者是否能够对破伤风免疫产生抗体反应。受试者将接受为期 180 天的筛查和随访，以确定他们对白喉破伤风疫苗接种的反应水平。